PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Initial manifestation and atypical site for metastatic synovial sarcoma in an immunocompetent adult patient: about a case and literature review.

Abstract Synovial sarcoma (SS) is a rare tumor. It is characterized by various sites of occurrence but rarely involves the chest. The tumor may be wrongly diagnosed as benign due to its slow growth. Less than 10% of patients present with metastatic cancer. Endobronchial metastases are exceptional. Immunohistochemical examination and cytogenetic analysis allow to distinguish it from other mesenchymal tumors. The presence of SYT-SSX fusion transcript allows the diagnosis. Surgery is used for localized tumors that can be treated with radiation therapy while chemiotherapy is used for metastatic tumors. The average rate of locoregional or metastatic recurrence two years after SS is 50%. We report the case of a 28-year old patient with metastatic SS characterized by its uncommon metastatic site. He presented with endobronchial metastasis revealing his disease, that had evolved for more than 2 years. The SS is life-threatening due to its slow and insidious growth. Prognosis is guarded. This study aimed to emphasize this atypical site for metastatic synovial sarcoma as well as to insist on the role of early diagnosis and treatment.
PMID
Related Publications

Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives.

Detection of SYT-SSX fusion gene in paraffin-embedded tissues and its clinicopathologic significance for synovial sarcoma.

Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients.

SYT-SSX fusion genes in synovial sarcoma of the thorax.

The classic prognostic factors tumor stage, tumor size, and tumor grade are the strongest predictors of outcome in synovial sarcoma: no role for SSX fusion type or ezrin expression.

Authors

Mayor MeshTerms
Keywords

Synovial sarcoma

bronchial bud

endobronchial metastasis

Journal Title the pan african medical journal
Publication Year Start




PMID- 29515721
OWN - NLM
STAT- MEDLINE
DCOM- 20180313
LR  - 20180313
IS  - 1937-8688 (Electronic)
VI  - 28
DP  - 2017
TI  - [Initial manifestation and atypical site for metastatic synovial sarcoma in an
      immunocompetent adult patient: about a case and literature review].
PG  - 103
LID - 10.11604/pamj.2017.28.103.13200 [doi]
AB  - Synovial sarcoma (SS) is a rare tumor. It is characterized by various sites of
      occurrence but rarely involves the chest. The tumor may be wrongly diagnosed as
      benign due to its slow growth. Less than 10% of patients present with metastatic 
      cancer. Endobronchial metastases are exceptional. Immunohistochemical examination
      and cytogenetic analysis allow to distinguish it from other mesenchymal tumors.
      The presence of SYT-SSX fusion transcript allows the diagnosis. Surgery is used
      for localized tumors that can be treated with radiation therapy while
      chemiotherapy is used for metastatic tumors. The average rate of locoregional or 
      metastatic recurrence two years after SS is 50%. We report the case of a 28-year 
      old patient with metastatic SS characterized by its uncommon metastatic site. He 
      presented with endobronchial metastasis revealing his disease, that had evolved
      for more than 2 years. The SS is life-threatening due to its slow and insidious
      growth. Prognosis is guarded. This study aimed to emphasize this atypical site
      for metastatic synovial sarcoma as well as to insist on the role of early
      diagnosis and treatment.
FAU - Atmane, Amina
AU  - Atmane A
AD  - Service de Pneumo-phtisiologie, Hopital Moulay Youssef, Faculte de Medecine et de
      Pharmacie, Universite Mohammed V, CHU Ibn Sina, Rabat, Maroc.
FAU - Hammi, Sanaa
AU  - Hammi S
AD  - Faculte de Medecine et de Pharmacie de Tanger, Universite Abdelmalek Essaadi,
      Tetouan, Maroc.
FAU - Regragui, Asmaa
AU  - Regragui A
AD  - Service Anatomopathologie, Hopital Universitaire International Cheikh Zaid,
      Rabat, Maroc.
FAU - Raoufi, Mohammed
AU  - Raoufi M
AD  - Service de Pneumo-phtisiologie, Hopital Moulay Youssef, Faculte de Medecine et de
      Pharmacie, Universite Mohammed V, CHU Ibn Sina, Rabat, Maroc.
FAU - Marc, Karima
AU  - Marc K
AD  - Service de Pneumo-phtisiologie, Hopital Moulay Youssef, Faculte de Medecine et de
      Pharmacie, Universite Mohammed V, CHU Ibn Sina, Rabat, Maroc.
FAU - Soualhi, Mouna
AU  - Soualhi M
AD  - Service de Pneumo-phtisiologie, Hopital Moulay Youssef, Faculte de Medecine et de
      Pharmacie, Universite Mohammed V, CHU Ibn Sina, Rabat, Maroc.
FAU - Zahraoui, Rachida
AU  - Zahraoui R
AD  - Service de Pneumo-phtisiologie, Hopital Moulay Youssef, Faculte de Medecine et de
      Pharmacie, Universite Mohammed V, CHU Ibn Sina, Rabat, Maroc.
FAU - Benamor, Jouda
AU  - Benamor J
AD  - Service de Pneumo-phtisiologie, Hopital Moulay Youssef, Faculte de Medecine et de
      Pharmacie, Universite Mohammed V, CHU Ibn Sina, Rabat, Maroc.
FAU - Bourkadi, Jamal Eddine
AU  - Bourkadi JE
AD  - Service de Pneumo-phtisiologie, Hopital Moulay Youssef, Faculte de Medecine et de
      Pharmacie, Universite Mohammed V, CHU Ibn Sina, Rabat, Maroc.
LA  - fre
PT  - Case Reports
PT  - Journal Article
PT  - Review
TT  - Mode revelateur original et localisation metastatique particuliere d'un
      synovialo-sarcome chez un adulte immunocompetent: a propos d'un cas avec revue de
      la litterature.
DEP - 20171004
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Adult
MH  - Bronchial Neoplasms/*diagnosis/secondary
MH  - Humans
MH  - Immunocompetence
MH  - Male
MH  - Prognosis
MH  - Sarcoma, Synovial/*diagnosis/pathology
PMC - PMC5837150
OTO - NOTNLM
OT  - Synovial sarcoma
OT  - bronchial bud
OT  - endobronchial metastasis
EDAT- 2018/03/09 06:00
MHDA- 2018/03/14 06:00
CRDT- 2018/03/09 06:00
PHST- 2017/06/29 00:00 [received]
PHST- 2017/09/12 00:00 [accepted]
PHST- 2018/03/09 06:00 [entrez]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/03/14 06:00 [medline]
AID - 10.11604/pamj.2017.28.103.13200 [doi]
AID - PAMJ-28-103 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 Oct 4;28:103. doi: 10.11604/pamj.2017.28.103.13200.
      eCollection 2017.