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Bullous pemphigoid and Parkinson's disease: about a case.

Abstract Bullous pemphigoid (BP) is an organ-specific autoimmune disease which can be associated with many pathologies including degenerative neurological diseases such as Parkinson's and Alzheimer's disease. Studies have suggested the possibility of cross-immune responses through "epitope spreading". Bullous dermatosis has been reported to be secondary to neurological disease, at intervals ranging from a few months to a maximum of a few years. Then is it an unusual association or a causation? It has been suggested that drug consumption, decubitus lesions, traumatic events as well as reduced immunity can be triggers for BP in patients with neurological disease. We report the case of a 93-year old patient with a 10-year history of advanced Parkinson's disease, hospitalized for the treatment of a common bullous pemphigoid confirmed by histology and immunohistochemistry. The patient was treated with oral corticosteroids. After a week of treatment, the patient died due to septic shock. Neurological disorders represent a real risk factor for BP. BP could be considered as a marker for neurological disorder. These associations are of broad interest, because they can play a role in the etiopathogenesis of BP and contribute to a complete understanding of the causes of these neurodegenerative diseases.
PMID
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Authors

Mayor MeshTerms
Keywords

Bullous pemphigoid

Parkinson's disease

neurological diseases

Journal Title the pan african medical journal
Publication Year Start




PMID- 29515729
OWN - NLM
STAT- MEDLINE
DCOM- 20180313
LR  - 20180313
IS  - 1937-8688 (Electronic)
VI  - 28
DP  - 2017
TI  - [Bullous pemphigoid and Parkinson's disease: about a case].
PG  - 111
LID - 10.11604/pamj.2017.28.111.12925 [doi]
AB  - Bullous pemphigoid (BP) is an organ-specific autoimmune disease which can be
      associated with many pathologies including degenerative neurological diseases
      such as Parkinson's and Alzheimer's disease. Studies have suggested the
      possibility of cross-immune responses through "epitope spreading". Bullous
      dermatosis has been reported to be secondary to neurological disease, at
      intervals ranging from a few months to a maximum of a few years. Then is it an
      unusual association or a causation? It has been suggested that drug consumption, 
      decubitus lesions, traumatic events as well as reduced immunity can be triggers
      for BP in patients with neurological disease. We report the case of a 93-year old
      patient with a 10-year history of advanced Parkinson's disease, hospitalized for 
      the treatment of a common bullous pemphigoid confirmed by histology and
      immunohistochemistry. The patient was treated with oral corticosteroids. After a 
      week of treatment, the patient died due to septic shock. Neurological disorders
      represent a real risk factor for BP. BP could be considered as a marker for
      neurological disorder. These associations are of broad interest, because they can
      play a role in the etiopathogenesis of BP and contribute to a complete
      understanding of the causes of these neurodegenerative diseases.
FAU - Zaouri, Hasnaa
AU  - Zaouri H
AD  - Service de Dermatologie, Centre Hospitalier Universitaire Avicenne, Faculte de
      Medecine et de Pharmacie Mohamed V, Rabat, Maroc.
FAU - Hassam, Baderdine
AU  - Hassam B
AD  - Service de Dermatologie, Centre Hospitalier Universitaire Avicenne, Faculte de
      Medecine et de Pharmacie Mohamed V, Rabat, Maroc.
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Pemphigoide bulleuse et maladie de Parkinson: a propos d'un cas.
DEP - 20171004
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Aged, 80 and over
MH  - Fatal Outcome
MH  - Humans
MH  - Male
MH  - Parkinson Disease/*complications
MH  - Pemphigoid, Bullous/*diagnosis/drug therapy/etiology
MH  - Risk Factors
MH  - Shock, Septic/*physiopathology
PMC - PMC5837137
OTO - NOTNLM
OT  - Bullous pemphigoid
OT  - Parkinson's disease
OT  - neurological diseases
EDAT- 2018/03/09 06:00
MHDA- 2018/03/14 06:00
CRDT- 2018/03/09 06:00
PHST- 2017/06/01 00:00 [received]
PHST- 2017/09/17 00:00 [accepted]
PHST- 2018/03/09 06:00 [entrez]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/03/14 06:00 [medline]
AID - 10.11604/pamj.2017.28.111.12925 [doi]
AID - PAMJ-28-111 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 Oct 4;28:111. doi: 10.11604/pamj.2017.28.111.12925.
      eCollection 2017.