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Factors leading to dyspepsia in renal transplant recipients.

Abstract Renal transplantation is the definitive treatment for end stage renal disease. Patients subjected to transplantation require lifelong immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia is a common disorder in these patients. The objective of this study was to determine factors leading to dyspepsia in renal (kidney) transplant recipients.
PMID
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Authors

Mayor MeshTerms

Kidney Transplantation

Keywords

Renal transplantation

dyspepsia

tacrolimus

Journal Title the pan african medical journal
Publication Year Start




PMID- 29515738
OWN - NLM
STAT- MEDLINE
DCOM- 20180313
LR  - 20180313
IS  - 1937-8688 (Electronic)
VI  - 28
DP  - 2017
TI  - Factors leading to dyspepsia in renal transplant recipients.
PG  - 120
LID - 10.11604/pamj.2017.28.120.12767 [doi]
AB  - Introduction: Renal transplantation is the definitive treatment for end stage
      renal disease. Patients subjected to transplantation require lifelong
      immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia 
      is a common disorder in these patients. The objective of this study was to
      determine factors leading to dyspepsia in renal (kidney) transplant recipients.
      Methods: It was a cross sectional study conducted at department of
      hepatogastroenterology and transplant sciences, SIUT Karachi, from 1-6-15 to
      1-12-15 for six months. All renal transplanted patients having dyspeptic symptoms
      for more than 6 weeks. EGD was performed, biopsy specimens obtained from antrum
      and duodenum, these were sent for histopathological examination. Frequency and
      percentages were obtained for categorical variables, mean +/- SD was calculated
      for continuous variables. Chi square test was used for categorical variable and
      student t-test for continuous variables. Results: Ninety patients were included
      in the study out of which 64 (71.1%) were males, mean age was 35.82 +/- 10.04
      years (range: 18-65 years). Gastritis (non H.pylori associated) in 78 (78.6%),
      duodenitis in 35 (38.9%) and H. pylori infection in 29 (32.2%), renal transplant 
      recipients. Most of the patients belonged to Sindhi ethnicity, 27 (30%), followed
      by Punjabi. Hypertension was the most common co-morbid condition in our patients 
      found in 29 (32.2%), while most of them don't have any co morbid condition.
      Duodenitis was found to be associated with tacrolimus use (p = 0.037).
      Conclusion: Gastritis is the most common factor accountable for this symptoms,
      followed by duodenitis and H. Pylori. Patients taking tacrolimus as
      immunosuppressant are more prone to develop duodenitis.
FAU - Nazeer, Aisha
AU  - Nazeer A
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and
      Transplantation, Karachi.
FAU - Rai, Ayesha Aslam
AU  - Rai AA
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and
      Transplantation, Karachi.
FAU - Luck, Nasir Hassan
AU  - Luck NH
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and
      Transplantation, Karachi.
LA  - eng
PT  - Journal Article
DEP - 20171006
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Immunosuppressive Agents)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Duodenitis/epidemiology
MH  - Dyspepsia/epidemiology/*etiology
MH  - Female
MH  - Gastritis/*epidemiology
MH  - Helicobacter Infections/epidemiology
MH  - Helicobacter pylori/isolation & purification
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage/adverse effects
MH  - Kidney Failure, Chronic/*surgery
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Pakistan
MH  - Risk Factors
MH  - Tacrolimus/administration & dosage/adverse effects
MH  - Young Adult
PMC - PMC5837158
OTO - NOTNLM
OT  - Renal transplantation
OT  - dyspepsia
OT  - tacrolimus
EDAT- 2018/03/09 06:00
MHDA- 2018/03/14 06:00
CRDT- 2018/03/09 06:00
PHST- 2017/05/17 00:00 [received]
PHST- 2017/09/04 00:00 [accepted]
PHST- 2018/03/09 06:00 [entrez]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/03/14 06:00 [medline]
AID - 10.11604/pamj.2017.28.120.12767 [doi]
AID - PAMJ-28-120 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 Oct 6;28:120. doi: 10.11604/pamj.2017.28.120.12767.
      eCollection 2017.