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Clinicopathologic characteristics and prognositic indicators of tonsillar mantle cell lymphoma.

Abstract The incidence of TMCL is low and prone to be misdiagnosed as tonsillitis. Patients with TMCL are more likely at stage Ⅰ-Ⅱ at presentation and the prognosis is better than that of NTMCL.
PMID
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Authors

Mayor MeshTerms
Keywords

Lymphoma, mantle-cell

Prognosis

Tonsillar neoplasms

Journal Title zhonghua bing li xue za zhi = chinese journal of pathology
Publication Year Start




PMID- 29534352
OWN - NLM
STAT- MEDLINE
DCOM- 20180323
LR  - 20180323
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 3
DP  - 2018 Mar 8
TI  - [Clinicopathologic characteristics and prognositic indicators of tonsillar mantle
      cell lymphoma].
PG  - 158-162
LID - 10.3760/cma.j.issn.0529-5807.2018.03.002 [doi]
AB  - Objective: To investigate clinicopathological features and prognosis of tonsillar
      mantle cell lymphoma(TMCL). Methods: Clinical data of 25 patients with TMCL at
      Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were
      included. All the cases were reviewed microscopically. Various
      immunohistochemical stains were performed using the MaxVision two-step method.
      IgH/CCND1 gene fusion was detected by fluorescent in situ hybridization(FISH).
      Additionally, randomly selected 40 cases of non-tonsil MCL of the same period
      were compared. Results: Among all mantle cell lymphomas (MCL), TMCL accounted for
      5.6%(25/449). The median age of the patients was 60 years(range: 44-82 years)
      with a MratioF ratio of 5.3 to 1.0. The main symptoms were sore throat and
      foreign body sensation and patients usually presented with enlargement or mass of
      tonsil. At the early stage of the disease, 18 cases(72.0%) were clinically
      misdiagnosed as tonsillitis. Lymph node involvement was present in 76.0%(19/25)
      of the patients. There were 4 cases(16.0%)with current splenic involvement, 11
      cases(44.0%) with pharyngeal focal recidivism, and 3 cases(12.0%) with
      involvement of other non-lymphoid organs. Morphologically, tonsillar
      architectures were effaced at various degrees. Eighteen MCL cases showed
      classical type and 7 cases were blastoid variant. All tumors were positive for
      CD20 and cyclin D1. 92.0%(23/25) tumors showed weakly positive or positive
      expression for CD5. FISH test that IgH/CCND1 gene fusion was positive in two CD5 
      negative classical cases. 18 patients(72.0%) had a median follow-up time of 26
      months(range: 6-81 months). The difference of survival rate between stage - and
      stage - patients was not statistically significant(P>0.05). Compared with NTMCL, 
      TMCL was found to have higher proportion of stage - disease (chi(2)=12.789,
      P<0.01), lower the proportion of non-lymphatic organ involvement (chi(2)=8.125,
      P<0.01), and better prognosis (chi(2)=4.351, P=0.037). Conclusion: The incidence 
      of TMCL is low and prone to be misdiagnosed as tonsillitis. Patients with TMCL
      are more likely at stage - at presentation and the prognosis is better than that 
      of NTMCL.
FAU - Hou, W H
AU  - Hou WH
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University,
      Beijing 100050, China.
FAU - Wei, P
AU  - Wei P
FAU - Xie, J L
AU  - Xie JL
FAU - Zheng, Y Y
AU  - Zheng YY
FAU - Zhang, Y L
AU  - Zhang YL
FAU - Zhou, X G
AU  - Zhou XG
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Antigens, CD20)
RN  - 0 (CCND1 protein, human)
RN  - 0 (CD5 Antigens)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD20/analysis
MH  - CD5 Antigens/analysis
MH  - Cyclin D1/analysis
MH  - Diagnostic Errors
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/pathology
MH  - Lymphoma, Mantle-Cell/*chemistry/mortality/*pathology
MH  - Middle Aged
MH  - Palatine Tonsil/pathology
MH  - Prognosis
MH  - Survival Rate
MH  - Tonsillar Neoplasms/*chemistry/mortality/*pathology
MH  - Tonsillitis/pathology
OTO - NOTNLM
OT  - Lymphoma, mantle-cell
OT  - Prognosis
OT  - Tonsillar neoplasms
EDAT- 2018/03/14 06:00
MHDA- 2018/03/24 06:00
CRDT- 2018/03/14 06:00
PHST- 2018/03/14 06:00 [entrez]
PHST- 2018/03/14 06:00 [pubmed]
PHST- 2018/03/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Mar 8;47(3):158-162.