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Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia in vivo.

Abstract Osteoporosis is linked to reduced bone mineral density (BMD) as a major risk factor for fragility fractures. Recent studies indicated an association between BMD and abnormally elevated lipid levels in blood as common indicators for hyperlipidemia. In this study, we assessed the protective effect of paeoniflorin, a phytochemical compound with multiple pharmacological activities, against hyperlipidemia-induced osteoporosis in rats fed a high-carbohydrate, high-fat diet (HCHF). The special diet-fed rats were subjected to an 8-week treatment with either paeoniflorin (20 mg/kg, daily) or vehicle. The control group received a normal diet during the entire study. At study conclusion, serum markers of lipid metabolism and bone turnover were measured. Bone strength was assessed by biomechanical testing, and femurs were scanned using micro-computed tomography to analyze trabecular and cortical bone structure. Interestingly, paeoniflorin controlled the serum lipid profile by significantly decreasing HCHF-induced high levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol. Paeoniflorin significantly improved trabecular and cortical parameters as well as femur length and width that were negatively affected by HCHF diet. Biomechanical strength testing showed that femurs of HCHF diet-fed rats endured significantly lower force but higher displacement and strain than those of control rats, whereas paeoniflorin reversed the negative effects. Moreover, paeoniflorin rescued osteoblast differentiation and cell spreading activities along with bone turnover markers. In conclusion, HCHF-induced hyperlipidemia caused adverse effects on the bone that were rescued by paeoniflorin treatment.
PMID
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Authors

Mayor MeshTerms
Keywords

Bone remodeling

Hyperlipidemia

Osteoporosis

Paeoniflorin

Journal Title biochemical and biophysical research communications
Publication Year Start




PMID- 29550473
OWN - NLM
STAT- MEDLINE
DCOM- 20180413
LR  - 20180413
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 498
IP  - 4
DP  - 2018 Apr 15
TI  - Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, 
      high-fat diet-associated hyperlipidemia in vivo.
PG  - 981-987
LID - S0006-291X(18)30585-0 [pii]
LID - 10.1016/j.bbrc.2018.03.093 [doi]
AB  - Osteoporosis is linked to reduced bone mineral density (BMD) as a major risk
      factor for fragility fractures. Recent studies indicated an association between
      BMD and abnormally elevated lipid levels in blood as common indicators for
      hyperlipidemia. In this study, we assessed the protective effect of paeoniflorin,
      a phytochemical compound with multiple pharmacological activities, against
      hyperlipidemia-induced osteoporosis in rats fed a high-carbohydrate, high-fat
      diet (HCHF). The special diet-fed rats were subjected to an 8-week treatment with
      either paeoniflorin (20mg/kg, daily) or vehicle. The control group received a
      normal diet during the entire study. At study conclusion, serum markers of lipid 
      metabolism and bone turnover were measured. Bone strength was assessed by
      biomechanical testing, and femurs were scanned using micro-computed tomography to
      analyze trabecular and cortical bone structure. Interestingly, paeoniflorin
      controlled the serum lipid profile by significantly decreasing HCHF-induced high 
      levels of total cholesterol, triglyceride, and low-density lipoprotein
      cholesterol. Paeoniflorin significantly improved trabecular and cortical
      parameters as well as femur length and width that were negatively affected by
      HCHF diet. Biomechanical strength testing showed that femurs of HCHF diet-fed
      rats endured significantly lower force but higher displacement and strain than
      those of control rats, whereas paeoniflorin reversed the negative effects.
      Moreover, paeoniflorin rescued osteoblast differentiation and cell spreading
      activities along with bone turnover markers. In conclusion, HCHF-induced
      hyperlipidemia caused adverse effects on the bone that were rescued by
      paeoniflorin treatment.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Wang, Yanmao
AU  - Wang Y
AD  - Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Yishan Rd 600, Shanghai 200233, PR China.
FAU - Zhu, Yu
AU  - Zhu Y
AD  - Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Yishan Rd 600, Shanghai 200233, PR China.
FAU - Lu, Shengdi
AU  - Lu S
AD  - Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Yishan Rd 600, Shanghai 200233, PR China.
FAU - Hu, Chengfang
AU  - Hu C
AD  - Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Yishan Rd 600, Shanghai 200233, PR China.
FAU - Zhong, Wanrun
AU  - Zhong W
AD  - Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Yishan Rd 600, Shanghai 200233, PR China. Electronic address: 
      [email protected]
FAU - Chai, Yimin
AU  - Chai Y
AD  - Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Yishan Rd 600, Shanghai 200233, PR China. Electronic address: 
      [email protected]
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180317
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Glucosides)
RN  - 0 (Monoterpenes)
RN  - 0 (Phytochemicals)
RN  - 21AIQ4EV64 (peoniflorin)
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena/drug effects
MH  - Bone Remodeling/drug effects
MH  - Diet, High-Fat/adverse effects
MH  - Dietary Carbohydrates/adverse effects
MH  - Femur
MH  - Glucosides/*therapeutic use
MH  - Hyperlipidemias/chemically induced/*complications
MH  - Lipid Metabolism/drug effects
MH  - Monoterpenes/*therapeutic use
MH  - Osteoporosis/*drug therapy/etiology
MH  - Phytochemicals/therapeutic use
MH  - Rats
OTO - NOTNLM
OT  - *Bone remodeling
OT  - *Hyperlipidemia
OT  - *Osteoporosis
OT  - *Paeoniflorin
EDAT- 2018/03/20 06:00
MHDA- 2018/04/14 06:00
CRDT- 2018/03/19 06:00
PHST- 2018/03/08 00:00 [received]
PHST- 2018/03/13 00:00 [accepted]
PHST- 2018/03/20 06:00 [pubmed]
PHST- 2018/04/14 06:00 [medline]
PHST- 2018/03/19 06:00 [entrez]
AID - S0006-291X(18)30585-0 [pii]
AID - 10.1016/j.bbrc.2018.03.093 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2018 Apr 15;498(4):981-987. doi:
      10.1016/j.bbrc.2018.03.093. Epub 2018 Mar 17.