PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Polydactyly in Development, Inheritance, and Evolution.

Abstract The occurrence of supernumerary digits or toes in humans and other tetrapods has attracted general interest since antiquity and later influenced scientific theories of development, inheritance, and evolution. Seventeenth-century genealogical studies of polydactyly were at the beginning of an understanding of the rules of inheritance. Features of polydactyly were also part of the classical disputes on the nature of development, including the preformation-versus-epigenesis and the atavism-versus-malformation debates. In the evolutionary domain, polydactyly was used in the criticism of the gradualist account of variation underlying Darwin’s theory. Today, extra digit formation plays a role in the conceptualization of gene regulation and pattern formation in vertebrate limb evolution. Recent genetic, experimental, and modeling accounts of extra digit formation highlight the existence of nongradual transitions in phenotypic states, suggesting a distinction between continuous and discontinuous variation in evolution. Unless otherwise noted, all translations are our own.
PMID
Related Publications
Authors

Mayor MeshTerms

Biological Evolution

Heredity

Inheritance Patterns

Keywords
Journal Title the quarterly review of biology
Publication Year Start




PMID- 29558608
OWN - NLM
STAT- MEDLINE
DCOM- 20180410
LR  - 20180410
IS  - 0033-5770 (Print)
IS  - 0033-5770 (Linking)
VI  - 92
IP  - 1
DP  - 2017 Mar
TI  - Polydactyly in Development, Inheritance, and Evolution.
PG  - 1-38
AB  - The occurrence of supernumerary digits or toes in humans and other tetrapods has 
      attracted general interest since antiquity and later influenced scientific
      theories of development, inheritance, and evolution. Seventeenth-century
      genealogical studies of polydactyly were at the beginning of an understanding of 
      the rules of inheritance. Features of polydactyly were also part of the classical
      disputes on the nature of development, including the
      preformation-versus-epigenesis and the atavism-versus-malformation debates. In
      the evolutionary domain, polydactyly was used in the criticism of the gradualist 
      account of variation underlying Darwin's theory. Today, extra digit formation
      plays a role in the conceptualization of gene regulation and pattern formation in
      vertebrate limb evolution. Recent genetic, experimental, and modeling accounts of
      extra digit formation highlight the existence of nongradual transitions in
      phenotypic states, suggesting a distinction between continuous and discontinuous 
      variation in evolution. Unless otherwise noted, all translations are our own.
FAU - Lange, Axel
AU  - Lange A
FAU - Muller, Gerd B
AU  - Muller GB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Q Rev Biol
JT  - The Quarterly review of biology
JID - 0376515
SB  - IM
MH  - Animals
MH  - *Biological Evolution
MH  - Epigenesis, Genetic
MH  - Genetic Predisposition to Disease
MH  - *Heredity
MH  - Humans
MH  - *Inheritance Patterns
MH  - Pedigree
MH  - Phenotype
MH  - Polydactyly/*genetics/*physiopathology
EDAT- 2018/03/21 06:00
MHDA- 2018/04/11 06:00
CRDT- 2018/03/21 06:00
PHST- 2018/03/21 06:00 [entrez]
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2018/04/11 06:00 [medline]
PST - ppublish
SO  - Q Rev Biol. 2017 Mar;92(1):1-38.