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Diagnostic Approach to Cardiac Involvement in Idiopathic Inflammatory Myopathies.

Abstract Cardiac involvement in idiopathic inflammatory myopathies (IIMs) attracts more attention than it ever did because of its morbidity and impact on worse prognosis, although the accurate information needs further epidemiological studies. Early identification and intervention for the diseased heart may help improve the clinical outcomes of IIMs with cardiac involvement. Cardiac troponin assays, allowing for sensitive detection of minor myocardium injury, may provide a new way for early detection for heart involvement in IIMs. While elevated cardiac troponin I (cTnI) specifically indicates cardiomyocyte injury, the elevation of cardiac troponin T (cTnT) levels may not only derive from damaged heart but also diseased adult skeletal muscles in which cTnT could re-express in patients with IIMs. cTnI is the biomarker of choice for diagnosis of cardiac involvement and may also be a prognostic factor in IIMs. Meanwhile, electrocardiography (ECG), cardiac imaging (e.g., echocardiography, cardiac magnetic resonance) and histopathological techniques (e.g., endomyocardial biopsy) take on different degrees of importance for the diagnosis of cardiac involvement. We propose a diagnostic strategy combining the routine use of cTnI assay with other techniques (routine ECG and echocardiography, cardiac magnetic resonance, and or endomyocardial biopsy in necessity) and clinical investigation for early detection of heart involvement in IIMs. Future researches are required to validate the algorithm for performance.
PMID
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Authors

Mayor MeshTerms
Keywords

Diagnosis

Diseased Heart

IIMs

cTnI

cTnT

Journal Title international heart journal
Publication Year Start




PMID- 29563381
OWN - NLM
STAT- MEDLINE
DCOM- 20180406
LR  - 20180406
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 59
IP  - 2
DP  - 2018 Mar 30
TI  - Diagnostic Approach to Cardiac Involvement in Idiopathic Inflammatory Myopathies.
PG  - 256-262
LID - 10.1536/ihj.17-204 [doi]
AB  - Cardiac involvement in idiopathic inflammatory myopathies (IIMs) attracts more
      attention than it ever did because of its morbidity and impact on worse
      prognosis, although the accurate information needs further epidemiological
      studies. Early identification and intervention for the diseased heart may help
      improve the clinical outcomes of IIMs with cardiac involvement. Cardiac troponin 
      assays, allowing for sensitive detection of minor myocardium injury, may provide 
      a new way for early detection for heart involvement in IIMs. While elevated
      cardiac troponin I (cTnI) specifically indicates cardiomyocyte injury, the
      elevation of cardiac troponin T (cTnT) levels may not only derive from damaged
      heart but also diseased adult skeletal muscles in which cTnT could re-express in 
      patients with IIMs. cTnI is the biomarker of choice for diagnosis of cardiac
      involvement and may also be a prognostic factor in IIMs. Meanwhile,
      electrocardiography (ECG), cardiac imaging (e.g., echocardiography, cardiac
      magnetic resonance) and histopathological techniques (e.g., endomyocardial
      biopsy) take on different degrees of importance for the diagnosis of cardiac
      involvement. We propose a diagnostic strategy combining the routine use of cTnI
      assay with other techniques (routine ECG and echocardiography, cardiac magnetic
      resonance, and or endomyocardial biopsy in necessity) and clinical investigation 
      for early detection of heart involvement in IIMs. Future researches are required 
      to validate the algorithm for performance.
FAU - Chen, Fei
AU  - Chen F
AD  - Department of Cardiology, West China Hospital, Sichuan University.
FAU - Peng, Yong
AU  - Peng Y
AD  - Department of Cardiology, West China Hospital, Sichuan University.
FAU - Chen, Mao
AU  - Chen M
AD  - Department of Cardiology, West China Hospital, Sichuan University.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180320
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
RN  - 0 (Troponin T)
SB  - IM
MH  - Biomarkers/blood
MH  - Heart Diseases/blood/*diagnosis/*etiology
MH  - Humans
MH  - Myositis/*complications
MH  - Troponin I/blood
MH  - Troponin T/blood
OTO - NOTNLM
OT  - Diagnosis
OT  - Diseased Heart
OT  - IIMs
OT  - cTnI
OT  - cTnT
EDAT- 2018/03/23 06:00
MHDA- 2018/04/07 06:00
CRDT- 2018/03/23 06:00
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2018/04/07 06:00 [medline]
PHST- 2018/03/23 06:00 [entrez]
AID - 10.1536/ihj.17-204 [doi]
PST - ppublish
SO  - Int Heart J. 2018 Mar 30;59(2):256-262. doi: 10.1536/ihj.17-204. Epub 2018 Mar
      20.