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Fatal Yellow Fever in Travelers to Brazil, 2018.

Abstract Yellow fever virus is a mosquito-borne flavivirus that causes yellow fever, an acute infectious disease that occurs in South America and sub-Saharan Africa. Most patients with yellow fever are asymptomatic, but among the 15% who develop severe illness, the case fatality rate is 20%-60%. Effective live-attenuated virus vaccines are available that protect against yellow fever (1). An outbreak of yellow fever began in Brazil in December 2016; since July 2017, cases in both humans and nonhuman primates have been reported from the states of São Paulo, Minas Gerais, and Rio de Janeiro, including cases occurring near large urban centers in these states (2). On January 16, 2018, the World Health Organization updated yellow fever vaccination recommendations for Brazil to include all persons traveling to or living in Espírito Santo, São Paulo, and Rio de Janeiro states, and certain cities in Bahia state, in addition to areas where vaccination had been recommended before the recent outbreak (3). Since January 2018, 10 travel-related cases of yellow fever, including four deaths, have been reported in international travelers returning from Brazil. None of the 10 travelers had received yellow fever vaccination.
PMID
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Authors

Mayor MeshTerms

Disease Outbreaks

Travel-Related Illness

Keywords
Journal Title mmwr. morbidity and mortality weekly report
Publication Year Start




PMID- 29565840
OWN - NLM
STAT- MEDLINE
DCOM- 20180323
LR  - 20180323
IS  - 1545-861X (Electronic)
IS  - 0149-2195 (Linking)
VI  - 67
IP  - 11
DP  - 2018 Mar 23
TI  - Fatal Yellow Fever in Travelers to Brazil, 2018.
PG  - 340-341
LID - 10.15585/mmwr.mm6711e1 [doi]
AB  - Yellow fever virus is a mosquito-borne flavivirus that causes yellow fever, an
      acute infectious disease that occurs in South America and sub-Saharan Africa.
      Most patients with yellow fever are asymptomatic, but among the 15% who develop
      severe illness, the case fatality rate is 20%-60%. Effective live-attenuated
      virus vaccines are available that protect against yellow fever (1). An outbreak
      of yellow fever began in Brazil in December 2016; since July 2017, cases in both 
      humans and nonhuman primates have been reported from the states of Sao Paulo,
      Minas Gerais, and Rio de Janeiro, including cases occurring near large urban
      centers in these states (2). On January 16, 2018, the World Health Organization
      updated yellow fever vaccination recommendations for Brazil to include all
      persons traveling to or living in Espirito Santo, Sao Paulo, and Rio de Janeiro
      states, and certain cities in Bahia state, in addition to areas where vaccination
      had been recommended before the recent outbreak (3). Since January 2018, 10
      travel-related cases of yellow fever, including four deaths, have been reported
      in international travelers returning from Brazil. None of the 10 travelers had
      received yellow fever vaccination.
FAU - Hamer, Davidson H
AU  - Hamer DH
FAU - Angelo, Kristina
AU  - Angelo K
FAU - Caumes, Eric
AU  - Caumes E
FAU - van Genderen, Perry J J
AU  - van Genderen PJJ
FAU - Florescu, Simin A
AU  - Florescu SA
FAU - Popescu, Corneliu P
AU  - Popescu CP
FAU - Perret, Cecilia
AU  - Perret C
FAU - McBride, Angela
AU  - McBride A
FAU - Checkley, Anna
AU  - Checkley A
FAU - Ryan, Jenny
AU  - Ryan J
FAU - Cetron, Martin
AU  - Cetron M
FAU - Schlagenhauf, Patricia
AU  - Schlagenhauf P
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180323
PL  - United States
TA  - MMWR Morb Mortal Wkly Rep
JT  - MMWR. Morbidity and mortality weekly report
JID - 7802429
SB  - IM
MH  - Adult
MH  - Brazil/epidemiology
MH  - *Disease Outbreaks
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Travel-Related Illness
MH  - Yellow Fever/*diagnosis/epidemiology
COIS- No conflicts of interest were reported.
EDAT- 2018/03/23 06:00
MHDA- 2018/03/24 06:00
CRDT- 2018/03/23 06:00
PHST- 2018/03/23 06:00 [entrez]
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2018/03/24 06:00 [medline]
AID - 10.15585/mmwr.mm6711e1 [doi]
PST - epublish
SO  - MMWR Morb Mortal Wkly Rep. 2018 Mar 23;67(11):340-341. doi:
      10.15585/mmwr.mm6711e1.