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4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and alleviates sepsis through of MAPK and NFκB suppression.

Abstract Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan, commonly used for the treatment of cancers and inflammatory disorders. 4-acetylantroquinonol B (4AAQB) is one of the active component isolated from the mycelium of A. cinnamomea. However, whether 4AAQB exhibits anti-inflammatory effect is not clear.
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Authors

Mayor MeshTerms
Keywords

4AAQB

Anti-inflammation

Antrodia cinnamomea

MAPK

NFκB

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 29566694
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20180402
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Mar 23
TI  - 4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and 
      alleviates sepsis through of MAPK and NFkappaB suppression.
PG  - 108
LID - 10.1186/s12906-018-2172-2 [doi]
AB  - BACKGROUND: Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan,
      commonly used for the treatment of cancers and inflammatory disorders.
      4-acetylantroquinonol B (4AAQB) is one of the active component isolated from the 
      mycelium of A. cinnamomea. However, whether 4AAQB exhibits anti-inflammatory
      effect is not clear. METHODS: The anti-inflammatory activity of 4AAQB was
      examined by ELISA to measure the pro-inflammatory cytokines production in
      lipopolysaccharide (LPS)-simulated RAW264.7 cells, peritoneal macrophages and in 
      mice. The effect of 4AAQB for MAPK kinase molecules phosphorylation in
      LPS-stimulated RAW264.7 macrophage including ERK, JNK and p38 were evaluated. The
      in vivo efficacy of 4AAQB was also demonstrated. RESULTS: In the present study,
      we found that 4AAQB exhibits anti-inflammatory effects inhibit tumor necrosis
      factor-alpha (TNF-alpha)/interleukin-6 (IL-6) releasing and LPS-stimulated
      phagocytes migration without affect cell growth. In addition, the MAPK kinase
      molecules phosphorylation in LPS-stimulated RAW264.7 macrophage including ERK,
      JNK and p38 was inhibited by 4AAQB. The phosphorylation of NFkappaB subunit p65
      and IkBalpha were also decreased after 4AAQB treatment. Furthermore, 4AAQB
      attenuates the cytokine production in LPS-induced and CLP-induced septic mice.
      CONCLUSION: These results showed that 4AAQB exhibited anti-inflammatory property 
      both in vitro and in vivo, suggesting that 4AAQB may be a therapeutic candidate
      which used in inflammatory disorders treatment.
FAU - Chang, Chien-Hsin
AU  - Chang CH
AD  - Institute of Pharmacology, College of Medicine, National Taiwan University,
      Taipei, Taiwan.
FAU - Hsu, Chun-Chieh
AU  - Hsu CC
AD  - Institute of Pharmacology, College of Medicine, National Taiwan University,
      Taipei, Taiwan.
AD  - Medical and Pharmaceutical Industry Technology and Development Center, New Taipei
      City, Taiwan.
FAU - Lee, An-Sheng
AU  - Lee AS
AD  - Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Jhong-Jheng Rd., 
      Sanzhi Dist, New Taipei City, Taiwan.
FAU - Wang, Shih-Wei
AU  - Wang SW
AD  - Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Jhong-Jheng Rd., 
      Sanzhi Dist, New Taipei City, Taiwan.
FAU - Lin, Kung-Tin
AU  - Lin KT
AD  - Institute of Pharmacology, College of Medicine, National Taiwan University,
      Taipei, Taiwan.
FAU - Chang, Wei-Luen
AU  - Chang WL
AD  - Institute of Pharmacology, College of Medicine, National Taiwan University,
      Taipei, Taiwan.
FAU - Peng, Hui-Chin
AU  - Peng HC
AD  - Institute of Pharmacology, College of Medicine, National Taiwan University,
      Taipei, Taiwan.
FAU - Huang, Wen-Chiung
AU  - Huang WC
AD  - Department of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan.
FAU - Chung, Ching-Hu
AU  - Chung CH
AUID- ORCID: http://orcid.org/0000-0002-3096-8974
AD  - Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Jhong-Jheng Rd., 
      Sanzhi Dist, New Taipei City, Taiwan. [email protected]
LA  - eng
GR  - 102-2320-B-715-002-MY2/Ministry of Science and Technology, Taiwan
GR  - MMC-1031A02, 1042E01, 1051C01, 1051E01, 1051B08, 1061E02 and 1061B22/Mackay
      Medical College
PT  - Journal Article
DEP - 20180323
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (4-acetylantroquinonol B)
RN  - 0 (Cyclohexanones)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - OL659KIY4X (4-Butyrolactone)
SB  - IM
MH  - 4-Butyrolactone/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Cell Survival/drug effects
MH  - Cyclohexanones/*pharmacology
MH  - Cytokines/metabolism
MH  - Lipopolysaccharides/*adverse effects
MH  - MAP Kinase Signaling System/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/*metabolism
MH  - RAW 264.7 Cells
MH  - Sepsis/*metabolism
PMC - PMC5865343
OTO - NOTNLM
OT  - 4AAQB
OT  - Anti-inflammation
OT  - Antrodia cinnamomea
OT  - MAPK
OT  - NFkappaB
EDAT- 2018/03/24 06:00
MHDA- 2018/04/03 06:00
CRDT- 2018/03/24 06:00
PHST- 2016/12/23 00:00 [received]
PHST- 2018/03/15 00:00 [accepted]
PHST- 2018/03/24 06:00 [entrez]
PHST- 2018/03/24 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
AID - 10.1186/s12906-018-2172-2 [doi]
AID - 10.1186/s12906-018-2172-2 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2018 Mar 23;18(1):108. doi: 10.1186/s12906-018-2172-2.