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The effect of triclosan-coated sutures on the rate of surgical site infection after hip and knee arthroplasty: a double-blind randomized controlled trial of 2546 patients.

Abstract Aims Surgical site infection (SSI) is a common complication of surgery with an incidence of about 1% in the United Kingdom. Sutures can lead to the development of a SSI, as micro-organisms can colonize the suture as it is implanted. Triclosan-coated sutures, being antimicrobical, were developed to reduce the rate of SSI. Our aim was to assess whether triclosan-coated sutures cause a reduction in SSIs following arthroplasty of the hip and knee. Patients and Methods This two-arm, parallel, double-blinded study involved 2546 patients undergoing elective total hip (THA) and total knee arthroplasty (TKA) at three hospitals. A total of 1323 were quasi-randomized to a standard suture group, and 1223 being quasi-randomized to the triclosan-coated suture group. The primary endpoint was the rate of SSI at 30 days postoperatively. Results The baseline characteristics of age, gender and comorbidities were well matched in the two groups. The rates of superficial SSI were 0.8% in the control group and 0.7% in the intervention group (p = 0.651), and when deep and superficial SSIs were combined the rates were 2.5% and 1.8 (p = 0.266). The length of stay in hospital and the rates of medical complications did not differ significantly between the groups (p = 1.000). Conclusion This trial provided no evidence that the use of triclosan-coated sutures at THA and TKA leads to a reduction in the rate of SSI. Cite this article: Bone Joint J 2018;100-B:296-302.
PMID
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The effect of triclosan coated sutures on rate of surgical site infection after hip and knee replacement: a protocol for a double-blind randomised controlled trial.

Authors

Mayor MeshTerms
Keywords

Antibacterial

Hip arthroplasty

Knee arthroplasty

Surgical site infection

Triclosan

Triclosan-coated sutures

Journal Title the bone & joint journal
Publication Year Start




PMID- 29589500
OWN - NLM
STAT- In-Process
LR  - 20180328
IS  - 2049-4408 (Electronic)
IS  - 2049-4394 (Linking)
VI  - 100-B
IP  - 3
DP  - 2018 Mar 1
TI  - The effect of triclosan-coated sutures on the rate of surgical site infection
      after hip and knee arthroplasty: a double-blind randomized controlled trial of
      2546 patients.
PG  - 296-302
LID - 10.1302/0301-620X.100B3.BJJ-2017-0247.R1 [doi]
AB  - Aims Surgical site infection (SSI) is a common complication of surgery with an
      incidence of about 1% in the United Kingdom. Sutures can lead to the development 
      of a SSI, as micro-organisms can colonize the suture as it is implanted.
      Triclosan-coated sutures, being antimicrobical, were developed to reduce the rate
      of SSI. Our aim was to assess whether triclosan-coated sutures cause a reduction 
      in SSIs following arthroplasty of the hip and knee. Patients and Methods This
      two-arm, parallel, double-blinded study involved 2546 patients undergoing
      elective total hip (THA) and total knee arthroplasty (TKA) at three hospitals. A 
      total of 1323 were quasi-randomized to a standard suture group, and 1223 being
      quasi-randomized to the triclosan-coated suture group. The primary endpoint was
      the rate of SSI at 30 days postoperatively. Results The baseline characteristics 
      of age, gender and comorbidities were well matched in the two groups. The rates
      of superficial SSI were 0.8% in the control group and 0.7% in the intervention
      group (p = 0.651), and when deep and superficial SSIs were combined the rates
      were 2.5% and 1.8 (p = 0.266). The length of stay in hospital and the rates of
      medical complications did not differ significantly between the groups (p =
      1.000). Conclusion This trial provided no evidence that the use of
      triclosan-coated sutures at THA and TKA leads to a reduction in the rate of SSI. 
      Cite this article: Bone Joint J 2018;100-B:296-302.
FAU - Sprowson, A P
AU  - Sprowson AP
AD  - University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2
      2DX, UK.
FAU - Jensen, C
AU  - Jensen C
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
FAU - Parsons, N
AU  - Parsons N
AD  - University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2
      2DX, UK.
FAU - Partington, P
AU  - Partington P
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
FAU - Emmerson, K
AU  - Emmerson K
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
FAU - Carluke, I
AU  - Carluke I
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
FAU - Asaad, S
AU  - Asaad S
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
FAU - Pratt, R
AU  - Pratt R
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
FAU - Muller, S
AU  - Muller S
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
FAU - Ahmed, I
AU  - Ahmed I
AD  - University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2
      2DX, UK.
FAU - Reed, M R
AU  - Reed MR
AD  - Wansbeck General Hospital, Woodhorn Lane, Northumberland NE63 9JJ, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bone Joint J
JT  - The bone & joint journal
JID - 101599229
OTO - NOTNLM
OT  - Antibacterial
OT  - Hip arthroplasty
OT  - Knee arthroplasty
OT  - Surgical site infection
OT  - Triclosan
OT  - Triclosan-coated sutures
EDAT- 2018/03/29 06:00
MHDA- 2018/03/29 06:00
CRDT- 2018/03/29 06:00
PHST- 2018/03/29 06:00 [entrez]
PHST- 2018/03/29 06:00 [pubmed]
PHST- 2018/03/29 06:00 [medline]
AID - 10.1302/0301-620X.100B3.BJJ-2017-0247.R1 [doi]
PST - ppublish
SO  - Bone Joint J. 2018 Mar 1;100-B(3):296-302. doi:
      10.1302/0301-620X.100B3.BJJ-2017-0247.R1.