PubTransformer

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PMID- 29595702
OWN - NLM
STAT- MEDLINE
DCOM- 20180411
LR  - 20180411
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 13
DP  - 2018 Mar
TI  - Coinfection with 2 Clostridium difficile ribotypes in China: A case report.
PG  - e9946
LID - 10.1097/MD.0000000000009946 [doi]
AB  - RATIONALE: Clostridium difficile infections (CDIs) have been reported in China,
      but detailed clinical symptoms of coinfection by 2 C difficile ribotypes have not
      been documented. PATIENTS CONCERNS: An 83-year-old male with a 10-day history of 
      diarrhea and urinary tract infection was admitted to the hospital. The patient
      had received ofloxacin for several days, but his clinical response was poor.
      Laboratory workup revealed high white blood cell (WBC), serum creatinine (Scr),
      and C-reactive protein (CRP) levels. Based on these abnormal lab results, rapid
      detection of glutamate dehydrogenase and toxin A and B was performed. DIAGNOSIS: 
      Severe CDI. INTERVENTIONS: Oral vancomycin was administered for 8 days. OUTCOMES:
      Diarrhea symptoms improved and C difficile culture was negative after oral
      vancomycin administration for 8 days. Clostridium difficile was isolated from 3
      consecutive stool samples at 2-day intervals because the patient was admitted to 
      the hospital. Polymerase chain reaction ribotyping revealed ribotype (RT) 017 in 
      the first 2 samples and RT 001 in the third sample. RT 017 caused significantly
      higher increases in the levels of WBC, Scr, and CRP than RT 001. LESSONS: It is
      necessary to improve clinicians' awareness of CDI and reduce the severity of CDI 
      caused by RT 017 in China.
FAU - Wang, Liqian
AU  - Wang L
AD  - Department of Laboratory Medicine, Zhejiang Chinese Medical University Affiliated
      Hangzhou First Hospital.
FAU - Luo, Yun
AU  - Luo Y
AD  - Department of Microbiology, Zhejiang Provincial Center for Disease Control and
      Prevention.
FAU - Huang, Chen
AU  - Huang C
AD  - Department of Microbiology, Zhejiang Provincial Center for Disease Control and
      Prevention.
FAU - Wu, Shenghai
AU  - Wu S
AD  - Department of Laboratory Medicine, Hangzhou First Hospital, Huansha road,
      Hangzhou, Zhejiang, China.
FAU - Ye, Julian
AU  - Ye J
AD  - Department of Microbiology, Zhejiang Provincial Center for Disease Control and
      Prevention.
FAU - Song, Xiaojun
AU  - Song X
AD  - Department of Microbiology, Zhejiang Provincial Center for Disease Control and
      Prevention.
FAU - Jin, Dazhi
AU  - Jin D
FAU - Wang, Xianjun
AU  - Wang X
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Anti-Bacterial Agents)
SB  - AIM
SB  - IM
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Clostridium Infections/drug therapy/*microbiology
MH  - Clostridium difficile/*classification
MH  - Coinfection
MH  - Humans
MH  - Male
MH  - Ribotyping
EDAT- 2018/03/30 06:00
MHDA- 2018/04/12 06:00
CRDT- 2018/03/30 06:00
PHST- 2018/03/30 06:00 [entrez]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2018/04/12 06:00 [medline]
AID - 10.1097/MD.0000000000009946 [doi]
AID - 00005792-201803300-00075 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Mar;97(13):e9946. doi: 10.1097/MD.0000000000009946.