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Two Cases of Meningococcal Disease in One Family Separated by an Extended Period - Colorado, 2015-2016.

Abstract On April 26, 2015, a case of meningococcal disease in a woman aged 75 years was reported to the Colorado Department of Public Health and Environment (CDPHE). As part of routine public health investigation and control activities, all seven family contacts of the patient were advised to receive appropriate postexposure prophylaxis (PEP) to eradicate nasopharyngeal carriage of meningococci and prevent secondary disease (1), although it is not known whether the family contacts complied with PEP recommendations. Fifteen months later, on June 6, 2016, CDPHE was notified that the grandchild of the first patient, a male infant aged 3 months who lived with the first patient, also had meningococcal disease. The infant's immediate family members (parents and one sibling) were among family contacts for whom PEP was recommended in 2015. Neisseria meningitidis isolates from both patients were found to be serogroup C at the CDPHE laboratory. Whole genome sequence (WGS) analysis at CDC found that both isolates had the same sequence type, indicating close genetic relatedness. These cases represent a possible instance of meningococcal disease transmission within a family, despite appropriate PEP recommendations and with a long interval between cases.
PMID
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Authors

Mayor MeshTerms

Family

Keywords
Journal Title mmwr. morbidity and mortality weekly report
Publication Year Start




PMID- 29596403
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20180402
IS  - 1545-861X (Electronic)
IS  - 0149-2195 (Linking)
VI  - 67
IP  - 12
DP  - 2018 Mar 30
TI  - Two Cases of Meningococcal Disease in One Family Separated by an Extended Period 
      - Colorado, 2015-2016.
PG  - 366-368
LID - 10.15585/mmwr.mm6712a4 [doi]
AB  - On April 26, 2015, a case of meningococcal disease in a woman aged 75 years was
      reported to the Colorado Department of Public Health and Environment (CDPHE). As 
      part of routine public health investigation and control activities, all seven
      family contacts of the patient were advised to receive appropriate postexposure
      prophylaxis (PEP) to eradicate nasopharyngeal carriage of meningococci and
      prevent secondary disease (1), although it is not known whether the family
      contacts complied with PEP recommendations. Fifteen months later, on June 6,
      2016, CDPHE was notified that the grandchild of the first patient, a male infant 
      aged 3 months who lived with the first patient, also had meningococcal disease.
      The infant's immediate family members (parents and one sibling) were among family
      contacts for whom PEP was recommended in 2015. Neisseria meningitidis isolates
      from both patients were found to be serogroup C at the CDPHE laboratory. Whole
      genome sequence (WGS) analysis at CDC found that both isolates had the same
      sequence type, indicating close genetic relatedness. These cases represent a
      possible instance of meningococcal disease transmission within a family, despite 
      appropriate PEP recommendations and with a long interval between cases.
FAU - Spence Davizon, Emily
AU  - Spence Davizon E
FAU - Soeters, Heidi M
AU  - Soeters HM
FAU - Miller, Lisa
AU  - Miller L
FAU - Barnes, Meghan
AU  - Barnes M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180330
PL  - United States
TA  - MMWR Morb Mortal Wkly Rep
JT  - MMWR. Morbidity and mortality weekly report
JID - 7802429
SB  - IM
MH  - Aged
MH  - Colorado
MH  - *Family
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Meningococcal Infections/*diagnosis/microbiology/prevention & control
MH  - Neisseria meningitidis, Serogroup C/isolation & purification
MH  - Post-Exposure Prophylaxis
COIS- No conflicts of interest were reported.
EDAT- 2018/03/30 06:00
MHDA- 2018/04/03 06:00
CRDT- 2018/03/30 06:00
PHST- 2018/03/30 06:00 [entrez]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
AID - 10.15585/mmwr.mm6712a4 [doi]
PST - epublish
SO  - MMWR Morb Mortal Wkly Rep. 2018 Mar 30;67(12):366-368. doi:
      10.15585/mmwr.mm6712a4.