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Periapical Cemento-osseous Dysplasia Is Rarely Diagnosed on Orthopantomograms of Patients with Neurofibromatosis Type 1 and Is Not a Gender-specific Feature of the Disease.

Abstract Several skeletal aberrations of the skull have been described for the tumor predisposition syndrome neurofibromatosis type 1 (NF1). Recently, periapical cemental/cemento-osseous dysplasia (COD) has been described in females affected with NF1. This reactive lesion of the hard tissues in tooth-bearing areas of the jaw has been proposed to represent a gender-specific radiological feature of NF1. The aim of this study was to investigate the prevalence of COD in patients with NF1.
PMID
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Authors

Mayor MeshTerms
Keywords

Neurofibromatosis type 1

cemento-osseous dysplasia

gender difference

periapical cemental dysplasia

Journal Title anticancer research
Publication Year Start




PMID- 29599350
OWN - NLM
STAT- MEDLINE
DCOM- 20180412
LR  - 20180412
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 4
DP  - 2018 Apr
TI  - Periapical Cemento-osseous Dysplasia Is Rarely Diagnosed on Orthopantomograms of 
      Patients with Neurofibromatosis Type 1 and Is Not a Gender-specific Feature of
      the Disease.
PG  - 2277-2284
AB  - Several skeletal aberrations of the skull have been described for the tumor
      predisposition syndrome neurofibromatosis type 1 (NF1). Recently, periapical
      cemental/cemento-osseous dysplasia (COD) has been described in females affected
      with NF1. This reactive lesion of the hard tissues in tooth-bearing areas of the 
      jaw has been proposed to represent a gender-specific radiological feature of NF1.
      The aim of this study was to investigate the prevalence of COD in patients with
      NF1. PATIENTS AND METHODS: The orthopantomograms (OPGs) of 179 patients with a
      confirmed diagnosis of NF1 were analyzed for COD. The results were compared to
      radiographic findings obtained in OPGs of age- and sex-matched controls. The NF1 
      patient group was further differentiated according to the evidence of facial
      plexiform neurofibroma. RESULTS: COD was a very rare finding in both groups. The 
      extension of the diagnostic criteria including radiologically-healthy teeth and a
      widened periodontal gap in the periapical area only marginally increased the
      number of considered cases. Although there was a somewhat more common occurrence 
      of such changes in the patient group compared to the control group and the number
      of affected women was greater than the number of men, none of these differences
      reached statistical significance. Furthermore, COD or widening of the
      periradicular periodontal space was not found to be associated with facial tumor 
      type in NF1. CONCLUSION: The investigation revealed that COD is not a diagnostic 
      feature of NF1. There is no clear association of the rare finding of COD with
      gender. These studies should be compared with patient groups of other ethnic
      backgrounds.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Friedrich, Reinhard E
AU  - Friedrich RE
AD  - Department of Oral and Craniomaxillofacial Surgery, Eppendorf University
      Hospital, University of Hamburg, Hamburg, Germany rfr[email protected]
AD  - Neurofibromatosis Laboratory, Hamburg-Lokstedt, Hamburg, Germany.
FAU - Reul, Anika
AU  - Reul A
AD  - Department of Oral and Craniomaxillofacial Surgery, Eppendorf University
      Hospital, University of Hamburg, Hamburg, Germany.
AD  - Neurofibromatosis Laboratory, Hamburg-Lokstedt, Hamburg, Germany.
AD  - Department of Prosthodontics, Eppendorf University Hospital, University of
      Hamburg, Hamburg, Germany.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - Gigantiform Cementoma, Familial
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Cementoma/*diagnosis/*epidemiology/pathology
MH  - Child
MH  - Facial Neoplasms/complications/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Jaw Neoplasms/*diagnosis/*epidemiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Neurofibroma, Plexiform/complications/epidemiology
MH  - Neurofibromatosis 1/complications/*epidemiology/pathology
MH  - Periapical Tissue/pathology
MH  - Radiography, Panoramic
MH  - Sex Factors
MH  - Young Adult
OTO - NOTNLM
OT  - *Neurofibromatosis type 1
OT  - *cemento-osseous dysplasia
OT  - *gender difference
OT  - *periapical cemental dysplasia
EDAT- 2018/03/31 06:00
MHDA- 2018/04/13 06:00
CRDT- 2018/03/31 06:00
PHST- 2018/01/11 00:00 [received]
PHST- 2018/02/09 00:00 [revised]
PHST- 2018/02/14 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/04/13 06:00 [medline]
AID - 38/4/2277 [pii]
AID - 10.21873/anticanres.12472 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Apr;38(4):2277-2284. doi: 10.21873/anticanres.12472.