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Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma.

Abstract Oral squamous cell carcinoma (OSCC) is an aggressive neoplasm. Many chromosomal and gene alterations have been identified in OSCC, including structural and numerical changes. In this study, we implemented a molecular assay of chromosome 7 (Chr7) in order to investigate the level of its numerical instability in OSCC.
PMID
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Authors

Mayor MeshTerms

Chromosome Aberrations

Keywords

Squamous cell carcinoma

chromosome7

in situ hybridization

microarrays

oral cavity

Journal Title anticancer research
Publication Year Start




PMID- 29599358
OWN - NLM
STAT- MEDLINE
DCOM- 20180412
LR  - 20180412
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 4
DP  - 2018 Apr
TI  - Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma.
PG  - 2339-2342
AB  - BACKGROUND: Oral squamous cell carcinoma (OSCC) is an aggressive neoplasm. Many
      chromosomal and gene alterations have been identified in OSCC, including
      structural and numerical changes. In this study, we implemented a molecular assay
      of chromosome 7 (Chr7) in order to investigate the level of its numerical
      instability in OSCC. MATERIALS AND METHODS: Using tissue microarray technology,
      30 primary OSCCs were cored and re-embedded into one recipient block. Chromogenic
      in situ hybridization assay was performed based on Chr7 centromeric
      probedetection. RESULTS: Chr 7 numerical analysis detected polysomy (trisomy/
      tetrasomy) in 4/30 (13.3%) of the examined tissue OSCC cores. Statistical
      significance was assessed correlating Chr7 numerical aberrations with stage
      (p=0.015), especially detected in cases not related to human papillomavirus (HPV)
      (p=0.01). CONCLUSION: Although Chr7 polysomy is a relatively rare gross genetic
      event in OSSC, it affects their biological behavior leading toa progressively
      aggressive phenotype (advanced stage). Furthermore, Chr7 polysomy is observed
      more frequently in non-viral (HPV) cases.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Mastronikolis, Nicholas S
AU  - Mastronikolis NS
AD  - ENT Department, Medical School, University of Patras, Patras, Greece.
FAU - Tsiambas, Evangelos
AU  - Tsiambas E
AD  - Department Pathology/Cytopathology, 417 VA Hospital, Athens, Greece
      [email protected]
FAU - Fotiades, Panagiotis P
AU  - Fotiades PP
AD  - Department of Surgery, Leicester General Hospital, Leicester, U.K.
FAU - Baliou, Evangelia
AU  - Baliou E
AD  - Department of Pathology, Hippokrateion Hospital, Athens, Greece.
FAU - Karameris, Andreas
AU  - Karameris A
AD  - Department Pathology/Cytopathology, 417 VA Hospital, Athens, Greece.
FAU - Peschos, Dimitrios
AU  - Peschos D
AD  - Department of Physiology, Medical School, University of Ioannina, Ioannina,
      Greece.
FAU - Mastronikolis, Stylianos N
AU  - Mastronikolis SN
AD  - Department of Medicine, School of Health Sciences, University of Crete,
      Heraklion, Crete.
FAU - Asimakopoulos, Asimakis D
AU  - Asimakopoulos AD
AD  - ENT Department, Luxembourg Hospital Center, Luxembourg, Luxembourg.
FAU - Giannakopoulos, Xenofon
AU  - Giannakopoulos X
AD  - Department of Urology, Medical School, University of Ioannina, Ioannina, Greece.
FAU - Ragos, Vasileios
AU  - Ragos V
AD  - Department of Maxillofacial, Medical School, University of Ioannina, Ioannina,
      Greece.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Allelic Imbalance
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mouth Neoplasms/*genetics/metabolism/pathology
MH  - Ploidies
MH  - Retrospective Studies
MH  - Tissue Array Analysis
OTO - NOTNLM
OT  - *Squamous cell carcinoma
OT  - *chromosome7
OT  - *in situ hybridization
OT  - *microarrays
OT  - *oral cavity
EDAT- 2018/03/31 06:00
MHDA- 2018/04/13 06:00
CRDT- 2018/03/31 06:00
PHST- 2018/01/18 00:00 [received]
PHST- 2018/02/15 00:00 [revised]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/04/13 06:00 [medline]
AID - 38/4/2339 [pii]
AID - 10.21873/anticanres.12480 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Apr;38(4):2339-2342. doi: 10.21873/anticanres.12480.