PubTransformer

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PMID- 29599370
OWN - NLM
STAT- MEDLINE
DCOM- 20180412
LR  - 20180412
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 4
DP  - 2018 Apr
TI  - Predictive Factors for Local Control and Survival in Patients with Cancer of
      Unknown Primary (CUP) Irradiated for Cerebral Metastases.
PG  - 2415-2418
AB  - BACKGROUND/AIM: To identify predictors of local control and survival after
      whole-brain irradiation (WBI) for cerebral metastases from cancer of unknown
      primary (CUP). PATIENTS AND METHODS: In 140 patients receiving WBI alone or
      following resection, seven factors were investigated including treatment
      approach, WBI-regimen, age, gender, Eastern Cooperative Oncology Group (ECOG)
      performance score, number of cerebral lesions and extra-cerebral metastases.
      RESULTS: On univariate analysis, resection plus WBI and boost (p=0.002), ECOG 0-1
      (p<0.001) and a single lesion (p<0.001) were positively associated with local
      control. On Cox regression, ECOG-score remained significant (p=0.002). On
      univariate analysis of survival, surgery plus WBI and boost (p=0.009), ECOG 0-1
      (p<0.001), a single lesion (p=0.024) and no extra-cerebral metastases (p<0.001)
      were associated with better outcomes. On Cox regression, ECOG-score (p<0.001) and
      extra-cerebral lesions (p<0.001) were significant. CONCLUSION: Significant
      predictors of local control and survival were identified that contribute to
      treatment personalization and design of prospective trials in patients with
      cerebral metastases from CUP.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Rades, Dirk
AU  - Rades D
AD  - Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
      [email protected]
AD  - Faculty of Medicine, Hanoi Medical University, Hanoi, Vietnam.
FAU - Dziggel, Liesa
AU  - Dziggel L
AD  - Department of Radiation Oncology, University of Lubeck, Lubeck, Germany.
FAU - Janssen, Stefan
AU  - Janssen S
AD  - Department of Radiation Oncology, University of Lubeck, Lubeck, Germany.
AD  - Private Practice of Radiation Oncology, Hannover, Germany.
FAU - Khoa, Mai Trong
AU  - Khoa MT
AD  - Faculty of Medicine, Hanoi Medical University, Hanoi, Vietnam.
AD  - Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
FAU - Duong, Vuong Ngoc
AU  - Duong VN
AD  - Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
FAU - Khiem, Vu Huu
AU  - Khiem VH
AD  - Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
FAU - Gebauer, Niklas
AU  - Gebauer N
AD  - Department of Hematology and Medical Oncology, University of Lubeck, Lubeck,
      Germany.
FAU - Bartscht, Tobias
AU  - Bartscht T
AD  - Department of Hematology and Medical Oncology, University of Lubeck, Lubeck,
      Germany.
FAU - Schild, Steven E
AU  - Schild SE
AD  - Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Neoplasms/*diagnosis/*mortality/*radiotherapy/secondary
MH  - Cranial Irradiation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Unknown Primary/*diagnosis/*mortality/*radiotherapy
MH  - Prognosis
MH  - Radiotherapy Dosage
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
OTO - NOTNLM
OT  - *Cancer of unknown primary (CUP)
OT  - *cerebral metastasis
OT  - *local control
OT  - *prognoses
OT  - *survival
OT  - *whole-brain irradiation
EDAT- 2018/03/31 06:00
MHDA- 2018/04/13 06:00
CRDT- 2018/03/31 06:00
PHST- 2018/01/25 00:00 [received]
PHST- 2018/02/16 00:00 [revised]
PHST- 2018/02/20 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/04/13 06:00 [medline]
AID - 38/4/2415 [pii]
AID - 10.21873/anticanres.12492 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Apr;38(4):2415-2418. doi: 10.21873/anticanres.12492.