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Clinicopathological Profiling of LC3B, an Autophagy Marker, and ESRRA (Estrogen-related Receptor-alpha) in Muscle-invasive Bladder Cancer.

Abstract Microtubule-associated protein 1 light chain 3B (LC3B), an autophagy marker, has been used as a promising marker in various cancer types. However, the expression of LC3B in muscle-invasive bladder cancer (MIBC) and its prognostic significance have not been investigated. Recent studies pointed to the involvement of ESRRA in regulating autophagy via both transcriptional and post-translational control. In the current study, prognostic importance of LC3B and ESRRA in MIBC was investigated.
PMID
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Authors

Mayor MeshTerms

Autophagy

Keywords

Muscle-invasive bladder cancer

autophagy

estrogen-related receptor-alpha. prognosis

microtubule-associated protein 1 light chain 3B

Journal Title anticancer research
Publication Year Start




PMID- 29599373
OWN - NLM
STAT- MEDLINE
DCOM- 20180412
LR  - 20180412
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 4
DP  - 2018 Apr
TI  - Clinicopathological Profiling of LC3B, an Autophagy Marker, and ESRRA
      (Estrogen-related Receptor-alpha) in Muscle-invasive Bladder Cancer.
PG  - 2429-2437
AB  - BACKGROUND/AIM: Microtubule-associated protein 1 light chain 3B (LC3B), an
      autophagy marker, has been used as a promising marker in various cancer types.
      However, the expression of LC3B in muscle-invasive bladder cancer (MIBC) and its 
      prognostic significance have not been investigated. Recent studies pointed to the
      involvement of ESRRA in regulating autophagy via both transcriptional and
      post-translational control. In the current study, prognostic importance of LC3B
      and ESRRA in MIBC was investigated. PATIENTS AND METHODS: We
      immunohistochemically studied the expression of LC3B and ESRRA in 56 MIBC
      samples. RESULTS: LC3B was stained high in 16 patients (28.6%) and low or
      negative in 40 patients (71.4%). ESRRA expression was high for 20 patients
      (35.7%) and low for 36 patients (64.3%). Both LC3B (p=0.003) and ESRRA (p=0.026) 
      expression correlated significantly with disease-free survival rates.
      Double-positive LC3B and ESRRA correlated with poor overall survival (p=0.007)
      and disease-free survival (p=0.001) in MIBC patients. CONCLUSION: LC3B and ESRRA 
      might be a useful prognostic factor in patients with MIBC. The co-expression of
      LC3B and ESRRA might be a prognostic and therapeutic target for patients with
      bladder cancer.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Kim, Sup
AU  - Kim S
AD  - Department of Pathology, Infection Control Convergence Research Center, College
      of Medicine, Chungnam National University, Daejeon, Republic of Korea.
AD  - Department of Microbiology, Infection Control Convergence Research Center,
      Chungnam National University, Daejeon, Republic of Korea.
AD  - Department of Medical Science, College of Medicine, Chungnam National University,
      Daejeon, Republic of Korea.
AD  - Department of Radiation Oncology, College of Medicine, Chungnam National
      University, Daejeon, Republic of Korea.
FAU - Lee, Adam Jaehyeok
AU  - Lee AJ
AD  - Department of Surgery, College of Medicine, Chungnam National University,
      Daejeon, Republic of Korea.
FAU - Yeo, Min-Kyung
AU  - Yeo MK
AD  - Department of Pathology, Infection Control Convergence Research Center, College
      of Medicine, Chungnam National University, Daejeon, Republic of Korea.
FAU - Na, Yong Gil
AU  - Na YG
AD  - Department of Urology, College of Medicine, Chungnam National University,
      Daejeon, Republic of Korea.
FAU - Kim, Ji-Yeon
AU  - Kim JY
AD  - Department of Surgery, College of Medicine, Chungnam National University,
      Daejeon, Republic of Korea.
FAU - Cho, Moon-June
AU  - Cho MJ
AD  - Department of Radiation Oncology, College of Medicine, Chungnam National
      University, Daejeon, Republic of Korea.
FAU - Kim, Jun-Sang
AU  - Kim JS
AD  - Department of Radiation Oncology, College of Medicine, Chungnam National
      University, Daejeon, Republic of Korea.
FAU - Jo, Eun-Kyeong
AU  - Jo EK
AD  - Department of Microbiology, Infection Control Convergence Research Center,
      Chungnam National University, Daejeon, Republic of Korea.
AD  - Department of Medical Science, College of Medicine, Chungnam National University,
      Daejeon, Republic of Korea.
FAU - Kim, Jin-Man
AU  - Kim JM
AD  - Department of Pathology, Infection Control Convergence Research Center, College
      of Medicine, Chungnam National University, Daejeon, Republic of Korea
      [email protected]
AD  - Department of Medical Science, College of Medicine, Chungnam National University,
      Daejeon, Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (ERRalpha estrogen-related receptor)
RN  - 0 (MAP1LC3B protein, human)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Autophagy
MH  - Biomarkers, Tumor/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Microtubule-Associated Proteins/*metabolism
MH  - Middle Aged
MH  - Muscle Neoplasms/*diagnosis/metabolism/*secondary
MH  - Neoplasm Invasiveness
MH  - Prognosis
MH  - Receptors, Estrogen/*metabolism
MH  - Tissue Array Analysis
MH  - Urinary Bladder Neoplasms/*diagnosis/metabolism/*pathology
OTO - NOTNLM
OT  - *Muscle-invasive bladder cancer
OT  - *autophagy
OT  - *estrogen-related receptor-alpha. prognosis
OT  - *microtubule-associated protein 1 light chain 3B
EDAT- 2018/03/31 06:00
MHDA- 2018/04/13 06:00
CRDT- 2018/03/31 06:00
PHST- 2018/01/05 00:00 [received]
PHST- 2018/01/31 00:00 [revised]
PHST- 2018/02/01 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/04/13 06:00 [medline]
AID - 38/4/2429 [pii]
AID - 10.21873/anticanres.12495 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Apr;38(4):2429-2437. doi: 10.21873/anticanres.12495.