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Suicidal hanging donors for lung transplantation: Is this chapter still closed? Midterm experience from a single center in United Kingdom.

Abstract In the context of limited donor pool in cardiothoracic transplantation, utilization of organs from high risk donors, such as suicidal hanging donors, while ensuring safety, is under consideration. We sought to evaluate the outcomes of lung transplantations (LTx) that use organs from this group.Between January 2011 and December 2015, 265 LTx were performed at our center. Twenty-two recipients received lungs from donors after suicidal hanging (group 1). The remaining 243 transplantations were used as a control (group 2). Analysis of recipient and donor characteristics as well as outcomes was performed.No statistically significant difference was found in the donor characteristics between analyzed groups, except for higher incidence of cardiac arrest, younger age and smoking history of hanging donors (P < .001, P = .022 and P = .0042, respectively). Recipient preoperative and perioperative characteristics were comparable. Postoperatively in group 1 there was a higher incidence of extracorporeal life support (27.3 vs 9.1%, P = .019). There were no significant differences in chronic lung allograft dysfunction-free survival between group 1 and 2: 92.3 vs 94% at 1 year and 65.9 vs 75.5% at 3 years (P = .99). The estimated cumulative survival rate was also similar between groups: 68.2 vs 83.2% at 1 year and 68.2% versus 72% at 3 years (P = .3758).Hanging as a donor cause of death is not associated with poor mid-term survival or chronic lung allograft dysfunction following transplantation. These results encourage assessment of lungs from hanging donors, and their consideration for transplantation.
PMID
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"Hanging donors": are we still skeptical about the lungs?

Authors

Mayor MeshTerms

Asphyxia

Suicide

Keywords
Journal Title medicine
Publication Year Start




PMID- 29620623
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20180416
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 14
DP  - 2018 Apr
TI  - Suicidal hanging donors for lung transplantation: Is this chapter still closed?
      Midterm experience from a single center in United Kingdom.
PG  - e0064
LID - 10.1097/MD.0000000000010064 [doi]
AB  - In the context of limited donor pool in cardiothoracic transplantation,
      utilization of organs from high risk donors, such as suicidal hanging donors,
      while ensuring safety, is under consideration. We sought to evaluate the outcomes
      of lung transplantations (LTx) that use organs from this group.Between January
      2011 and December 2015, 265 LTx were performed at our center. Twenty-two
      recipients received lungs from donors after suicidal hanging (group 1). The
      remaining 243 transplantations were used as a control (group 2). Analysis of
      recipient and donor characteristics as well as outcomes was performed.No
      statistically significant difference was found in the donor characteristics
      between analyzed groups, except for higher incidence of cardiac arrest, younger
      age and smoking history of hanging donors (P &lt; .001, P = .022 and P = .0042,
      respectively). Recipient preoperative and perioperative characteristics were
      comparable. Postoperatively in group 1 there was a higher incidence of
      extracorporeal life support (27.3 vs 9.1%, P = .019). There were no significant
      differences in chronic lung allograft dysfunction-free survival between group 1
      and 2: 92.3 vs 94% at 1 year and 65.9 vs 75.5% at 3 years (P = .99). The
      estimated cumulative survival rate was also similar between groups: 68.2 vs 83.2%
      at 1 year and 68.2% versus 72% at 3 years (P = .3758).Hanging as a donor cause of
      death is not associated with poor mid-term survival or chronic lung allograft
      dysfunction following transplantation. These results encourage assessment of
      lungs from hanging donors, and their consideration for transplantation.
FAU - Ananiadou, Olga
AU  - Ananiadou O
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Schmack, Bastian
AU  - Schmack B
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Zych, Bartlomiej
AU  - Zych B
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Sabashnikov, Anton
AU  - Sabashnikov A
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Garcia-Saez, Diana
AU  - Garcia-Saez D
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Mohite, Prashant
AU  - Mohite P
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Weymann, Alexander
AU  - Weymann A
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Mansur, Ashham
AU  - Mansur A
AD  - Department of Anesthesiology, University Medical Center, Georg August University,
      Goettingen, Germany.
FAU - Zeriouh, Mohamed
AU  - Zeriouh M
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Marczin, Nandor
AU  - Marczin N
AD  - Faculty of Medicine, National Heart &amp; Lung Institute, Imperial College, Heart
      Science Centre, Harefield Hospital, Harefield.
AD  - Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine,
      Imperial College London, Chelsea and Westminster Hospital, London, United
      Kingdom.
FAU - De Robertis, Fabio
AU  - De Robertis F
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Simon, Andre Rudiger
AU  - Simon AR
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
FAU - Popov, Aron-Frederik
AU  - Popov AF
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield,
      United Kingdom.
AD  - Department of Cardiothoracic Surgery, University of Frankfurt, Frankfurt,
      Germany.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - *Asphyxia
MH  - Case-Control Studies
MH  - Cause of Death
MH  - Female
MH  - Humans
MH  - Lung Transplantation/mortality/*statistics &amp; numerical data
MH  - Male
MH  - Prospective Studies
MH  - *Suicide
MH  - Survival Rate
MH  - Tissue Donors/*supply &amp; distribution
MH  - Tissue and Organ Procurement/*methods
MH  - Treatment Outcome
MH  - United Kingdom
EDAT- 2018/04/06 06:00
MHDA- 2018/04/17 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
AID - 10.1097/MD.0000000000010064 [doi]
AID - 00005792-201804060-00001 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(14):e0064. doi: 10.1097/MD.0000000000010064.