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Efficacy of escitalopram oxalate for patients with post-stroke depression.

Abstract This retrospective study investigated the efficacy and safety of escitalopram oxalate (ESO) for the treatment of post-stroke depression (PSD).A total of 115 patients with PSD were included in this study. A total of 65 patients underwent ESO (Intervention group). A total of 50 patients received acupressure (Control group). The outcome measurements included Montgomery-Åsberg Depression Rating Scale (MADRS), Hamilton Anxiety Rating Scale (HAM-A), and Sheehan Disability Scale (SDS). In addition, we also recorded the adverse events in this study.At the end of 8-week treatment, ESO showed greater efficacy in depression, measured by MADRS (P < .01); anxiety, measured by HAM-A scale (P < .01); and disability, measured by SDS (P < .01), compared to acupressure. Additionally, there were not significant differences regarding adverse events between two groups (P > .05).The present results indicate that ESO can decrease symptoms of patients with PSD.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29620632
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20180416
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 14
DP  - 2018 Apr
TI  - Efficacy of escitalopram oxalate for patients with post-stroke depression.
PG  - e0219
LID - 10.1097/MD.0000000000010219 [doi]
AB  - This retrospective study investigated the efficacy and safety of escitalopram
      oxalate (ESO) for the treatment of post-stroke depression (PSD).A total of 115
      patients with PSD were included in this study. A total of 65 patients underwent
      ESO (Intervention group). A total of 50 patients received acupressure (Control
      group). The outcome measurements included Montgomery-Asberg Depression Rating
      Scale (MADRS), Hamilton Anxiety Rating Scale (HAM-A), and Sheehan Disability
      Scale (SDS). In addition, we also recorded the adverse events in this study.At
      the end of 8-week treatment, ESO showed greater efficacy in depression, measured 
      by MADRS (P &lt; .01); anxiety, measured by HAM-A scale (P &lt; .01); and disability,
      measured by SDS (P &lt; .01), compared to acupressure. Additionally, there were not 
      significant differences regarding adverse events between two groups (P &gt; .05).The
      present results indicate that ESO can decrease symptoms of patients with PSD.
FAU - Xu, Ji-Hua
AU  - Xu JH
FAU - Jiang, Peng
AU  - Jiang P
LA  - eng
PT  - Evaluation Studies
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0DHU5B8D6V (Citalopram)
SB  - AIM
SB  - IM
MH  - Acupressure/statistics &amp; numerical data
MH  - Aged
MH  - Antidepressive Agents, Second-Generation/*therapeutic use
MH  - Citalopram/*therapeutic use
MH  - Depression/*drug therapy/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Retrospective Studies
MH  - Stroke/*psychology
MH  - Treatment Outcome
EDAT- 2018/04/06 06:00
MHDA- 2018/04/17 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
AID - 10.1097/MD.0000000000010219 [doi]
AID - 00005792-201804060-00010 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(14):e0219. doi: 10.1097/MD.0000000000010219.