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Relationships between patient characteristics and contrast agent dose for successful computed tomography venography with a body-weight-tailored contrast protocol.

Abstract The aim of this study was to evaluate the effect of patient characteristics on the contrast agent dosage that is required to reach effective enhancement of the inferior vena cava (IVC) on computed tomography venographs (CTV).This retrospective study included 50 patients who underwent CTV at 80 kVp. The contrast injection protocol (iodine 600 mg/kg) was tailored to their body weight. We calculated the required contrast agent volume (CAVmean-IVC) to reach the mean enhancement of IVC. We performed univariate and multivariate linear regression analyses between the sex, age, body weight (BW), lean body weight (LBW), body surface area (BSA), height (HT), estimated glomerular filtration rate (eGFR), and CAVmean-IVC.The univariate linear regression analysis show that HT, BW, LBW, and BSA were significantly correlated with CAVmean-IVC (P < .01 for all). The CAVmean-IVC was significantly higher for males than females (P < .01). Multivariate regression analysis showed that BW, LBW, and BSA had a statistically significant effect on CAVmean-IVC. There was no significant correlation of age, HT, or eGFR with CAVmean-IVC.BW, LBW, and BSA each had an independent significant effect on CAVmean-IVC. The conventional BW-tailored contrast injection protocol might be insufficient for CTV.
PMID
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Authors

Mayor MeshTerms

Body Weight

Keywords
Journal Title medicine
Publication Year Start




PMID- 29620634
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20180416
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 14
DP  - 2018 Apr
TI  - Relationships between patient characteristics and contrast agent dose for
      successful computed tomography venography with a body-weight-tailored contrast
      protocol.
PG  - e0231
LID - 10.1097/MD.0000000000010231 [doi]
AB  - The aim of this study was to evaluate the effect of patient characteristics on
      the contrast agent dosage that is required to reach effective enhancement of the 
      inferior vena cava (IVC) on computed tomography venographs (CTV).This
      retrospective study included 50 patients who underwent CTV at 80 kVp. The
      contrast injection protocol (iodine 600 mg/kg) was tailored to their body weight.
      We calculated the required contrast agent volume (CAVmean-IVC) to reach the mean 
      enhancement of IVC. We performed univariate and multivariate linear regression
      analyses between the sex, age, body weight (BW), lean body weight (LBW), body
      surface area (BSA), height (HT), estimated glomerular filtration rate (eGFR), and
      CAVmean-IVC.The univariate linear regression analysis show that HT, BW, LBW, and 
      BSA were significantly correlated with CAVmean-IVC (P &lt; .01 for all). The
      CAVmean-IVC was significantly higher for males than females (P &lt; .01).
      Multivariate regression analysis showed that BW, LBW, and BSA had a statistically
      significant effect on CAVmean-IVC. There was no significant correlation of age,
      HT, or eGFR with CAVmean-IVC.BW, LBW, and BSA each had an independent significant
      effect on CAVmean-IVC. The conventional BW-tailored contrast injection protocol
      might be insufficient for CTV.
FAU - Iyama, Yuji
AU  - Iyama Y
AD  - Department of Diagnostic Radiology, Kumamoto chuo hospital.
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto
      University, Kumamoto, Japan.
FAU - Nakaura, Takeshi
AU  - Nakaura T
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto
      University, Kumamoto, Japan.
FAU - Kidoh, Masafumi
AU  - Kidoh M
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto
      University, Kumamoto, Japan.
FAU - Katahira, Kazuhiro
AU  - Katahira K
AD  - Department of Diagnostic Radiology, Kumamoto chuo hospital.
FAU - Oda, Seitaro
AU  - Oda S
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto
      University, Kumamoto, Japan.
FAU - Utsunomiya, Daisuke
AU  - Utsunomiya D
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto
      University, Kumamoto, Japan.
FAU - Yamashita, Yasuyuki
AU  - Yamashita Y
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto
      University, Kumamoto, Japan.
LA  - eng
PT  - Evaluation Studies
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Contrast Media)
RN  - 9679TC07X4 (Iodine)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Body Weight
MH  - Computed Tomography Angiography/*methods
MH  - Contrast Media/*administration &amp; dosage
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - Iodine/*administration &amp; dosage
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Phlebography/*methods
MH  - Retrospective Studies
MH  - Vena Cava, Inferior/diagnostic imaging
MH  - Young Adult
EDAT- 2018/04/06 06:00
MHDA- 2018/04/17 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
AID - 10.1097/MD.0000000000010231 [doi]
AID - 00005792-201804060-00012 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(14):e0231. doi: 10.1097/MD.0000000000010231.