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Effects of a low salt diet on isolated systolic hypertension: A community-based population study.

Abstract Evidence has shown that long-term sodium reduction can not only reduce blood pressure, but also provide cardiovascular benefits. To date, there is little evidence related to the effects of salt reduction on isolated systolic hypertension (ISH).A total of 126 hypertensive patients were divided into an ISH group (n = 51) and a non-ISH (NISH) group (n = 75). The members of each group were then randomly assigned to low sodium salt (LSSalt) or normal salt (NSalt) diets for 6 months. Their blood pressure was measured every 2 months. Serum plasma renin-angiotensin activity, blood biochemical assays and urinary measurements were determined at the baseline and at the end of the 6 months.At the end of the study, the mean systolic blood pressure (SBP) of the ISH LSSalt group had significantly decreased by 10.18 mm Hg (95% confidence interval (CI): 3.13 to 17.2, P = .006) compared with that of the ISH NSalt group, while the mean SBP only decreased by 5.10 mm Hg (95% CI: -2.02 to 12.2, P = .158) in the NISH LSSalt group compared with that of the NISH NSalt group. The mean diastolic blood pressure (DBP) had no significant differences in the ISH and NISH groups. No obvious renin angiotensin system activation was found after LSSalt intervention. Regarding the urinary excretion of electrolytes and blood biochemical assays, the LSSalt treatment had the same effects on the ISH group as on the NISH group.The present study showed that the SBP of ISH patients was significantly decreased with the LSSalt intervention, while neither the SBP of the NISH patients nor the DBP of either group were similarly decreased, which indicated that ISH patients were more sensitive to salt restriction.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29620663
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20180416
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 14
DP  - 2018 Apr
TI  - Effects of a low salt diet on isolated systolic hypertension: A community-based
      population study.
PG  - e0342
LID - 10.1097/MD.0000000000010342 [doi]
AB  - Evidence has shown that long-term sodium reduction can not only reduce blood
      pressure, but also provide cardiovascular benefits. To date, there is little
      evidence related to the effects of salt reduction on isolated systolic
      hypertension (ISH).A total of 126 hypertensive patients were divided into an ISH 
      group (n = 51) and a non-ISH (NISH) group (n = 75). The members of each group
      were then randomly assigned to low sodium salt (LSSalt) or normal salt (NSalt)
      diets for 6 months. Their blood pressure was measured every 2 months. Serum
      plasma renin-angiotensin activity, blood biochemical assays and urinary
      measurements were determined at the baseline and at the end of the 6 months.At
      the end of the study, the mean systolic blood pressure (SBP) of the ISH LSSalt
      group had significantly decreased by 10.18 mm Hg (95% confidence interval (CI):
      3.13 to 17.2, P = .006) compared with that of the ISH NSalt group, while the mean
      SBP only decreased by 5.10 mm Hg (95% CI: -2.02 to 12.2, P = .158) in the NISH
      LSSalt group compared with that of the NISH NSalt group. The mean diastolic blood
      pressure (DBP) had no significant differences in the ISH and NISH groups. No
      obvious renin angiotensin system activation was found after LSSalt intervention. 
      Regarding the urinary excretion of electrolytes and blood biochemical assays, the
      LSSalt treatment had the same effects on the ISH group as on the NISH group.The
      present study showed that the SBP of ISH patients was significantly decreased
      with the LSSalt intervention, while neither the SBP of the NISH patients nor the 
      DBP of either group were similarly decreased, which indicated that ISH patients
      were more sensitive to salt restriction.
FAU - Yang, Guo-Hong
AU  - Yang GH
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury,
      Pingjin Hospital Heart Center, Tianjin, China.
FAU - Zhou, Xin
AU  - Zhou X
FAU - Ji, Wen-Jie
AU  - Ji WJ
FAU - Liu, Jun-Xiang
AU  - Liu JX
FAU - Sun, Jing
AU  - Sun J
FAU - Shi, Rui
AU  - Shi R
FAU - Jiang, Tie-Min
AU  - Jiang TM
FAU - Li, Yu-Ming
AU  - Li YM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Sodium Chloride, Dietary)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/physiology
MH  - Diet, Sodium-Restricted/*methods
MH  - Female
MH  - Humans
MH  - Hypertension/*diet therapy/etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Single-Blind Method
MH  - Sodium Chloride, Dietary/adverse effects
MH  - Systole/physiology
MH  - Treatment Outcome
EDAT- 2018/04/06 06:00
MHDA- 2018/04/17 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
AID - 10.1097/MD.0000000000010342 [doi]
AID - 00005792-201804060-00041 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(14):e0342. doi: 10.1097/MD.0000000000010342.