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Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study.

Abstract Monocyte chemoattractant protein 1 (MCP-1) is an initiating cytokine of the inflammatory cascade. Extracellular MCP-1 exhibits pro-inflammatory characteristic and plays a central pathogenic role in critical illness. The purpose of the study was to identify the association between plasma MCP-1 levels and the development of sepsis after severe trauma.The plasma levels of MCP-1 in severe trauma patients were measured by a quantitative enzyme-linked immune sorbent assay and the dynamic release patterns were recorded at three time points during seven days post-trauma. The related factors of prognosis were compared between sepsis and non-sepsis groups and analyzed using multivariate logistic regression analysis. We also used receiver operating characteristic (ROC) curves to assess the values of different variables in predicting sepsis.A total of 72 patients who met criteria indicative of severe trauma (72.22% of male; mean age, 49.40 ± 14.29 years) were enrolled. Plasma MCP-1 concentrations significantly increased on post-trauma day 1 and that this increase was significantly correlated with the Injury Severity Score (ISS) and interleukin-6 (IL-6). Multivariate logistic regression analysis showed that early MCP-1, ISS, and IL-6 were independent risk factors for sepsis in severe trauma patients. Incorporation of the early MCP-1 into the ISS can increase the discriminative performance for predicting development of sepsis.Early plasma MCP-1 concentrations can be used to assess the severity of trauma and is correlated with the development of sepsis after severe trauma. The addition of the early MCP-1 levels to the ISS significantly improves its ability to predict development of sepsis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29620667
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20180416
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 14
DP  - 2018 Apr
TI  - Early plasma monocyte chemoattractant protein 1 predicts the development of
      sepsis in trauma patients: A prospective observational study.
PG  - e0356
LID - 10.1097/MD.0000000000010356 [doi]
AB  - Monocyte chemoattractant protein 1 (MCP-1) is an initiating cytokine of the
      inflammatory cascade. Extracellular MCP-1 exhibits pro-inflammatory
      characteristic and plays a central pathogenic role in critical illness. The
      purpose of the study was to identify the association between plasma MCP-1 levels 
      and the development of sepsis after severe trauma.The plasma levels of MCP-1 in
      severe trauma patients were measured by a quantitative enzyme-linked immune
      sorbent assay and the dynamic release patterns were recorded at three time points
      during seven days post-trauma. The related factors of prognosis were compared
      between sepsis and non-sepsis groups and analyzed using multivariate logistic
      regression analysis. We also used receiver operating characteristic (ROC) curves 
      to assess the values of different variables in predicting sepsis.A total of 72
      patients who met criteria indicative of severe trauma (72.22% of male; mean age, 
      49.40 +/- 14.29 years) were enrolled. Plasma MCP-1 concentrations significantly
      increased on post-trauma day 1 and that this increase was significantly
      correlated with the Injury Severity Score (ISS) and interleukin-6 (IL-6).
      Multivariate logistic regression analysis showed that early MCP-1, ISS, and IL-6 
      were independent risk factors for sepsis in severe trauma patients. Incorporation
      of the early MCP-1 into the ISS can increase the discriminative performance for
      predicting development of sepsis.Early plasma MCP-1 concentrations can be used to
      assess the severity of trauma and is correlated with the development of sepsis
      after severe trauma. The addition of the early MCP-1 levels to the ISS
      significantly improves its ability to predict development of sepsis.
FAU - Wang, Yuchang
AU  - Wang Y
AD  - Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College of
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Liu, Qinxin
AU  - Liu Q
FAU - Liu, Tao
AU  - Liu T
FAU - Zheng, Qiang
AU  - Zheng Q
FAU - Xu, Xi'e
AU  - Xu X
FAU - Liu, Xinghua
AU  - Liu X
FAU - Gao, Wei
AU  - Gao W
FAU - Li, Zhanfei
AU  - Li Z
FAU - Bai, Xiangjun
AU  - Bai X
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Injury Severity Score
MH  - Interleukin-6/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sepsis/*etiology
MH  - Wounds and Injuries/*blood/complications
EDAT- 2018/04/06 06:00
MHDA- 2018/04/17 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
AID - 10.1097/MD.0000000000010356 [doi]
AID - 00005792-201804060-00045 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(14):e0356. doi: 10.1097/MD.0000000000010356.