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Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and its relationship with HPV/HIV co-infection.

Abstract HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. HPV infections can be facilitated by co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction and DNA direct sequencing were used to perform HPV genotyping. Statistical analyses were performed regarding risk factors for HPV/HIV co-infection and the occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%), followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer (P = .84) or HPV prevalence in different years (P = .25/P = .63). CD4 count also did not affect the risk for cervical lesions in the tested samples (P = .15/P = .28). Although the HIV viral load was not correlated with an increase in cervical lesion detection in the first group of analyzed samples (P = .12), it did affect cervical cancer risk in the group of samples analyzed in the following year (P = .045). HIV-infected patients presented a high prevalence of HPV co-infection, and HPV16 and HPV56 were the most prevalent genotypes. Considering this, it is possible that immunodeficiency can contribute to increased susceptibility to HPV56 infection in HIV-infected patients. The association between HIV viral load and the lesions also confirmed the importance of monitoring HIV/HPV co-infected patients with high HIV viral loads.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29620669
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20180416
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 14
DP  - 2018 Apr
TI  - Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and 
      its relationship with HPV/HIV co-infection.
PG  - e9545
LID - 10.1097/MD.0000000000009545 [doi]
AB  - HPV have been identified as high-risk and low-risk, depending on their
      association with the development of cancer. HPV infections can be facilitated by 
      co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the
      risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80
      cervical swab samples collected in 2 consecutive years. Polymerase chain reaction
      and DNA direct sequencing were used to perform HPV genotyping. Statistical
      analyses were performed regarding risk factors for HPV/HIV co-infection and the
      occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and 
      high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%),
      followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer
      (P = .84) or HPV prevalence in different years (P = .25/P = .63). CD4 count also 
      did not affect the risk for cervical lesions in the tested samples (P = .15/P =
      .28). Although the HIV viral load was not correlated with an increase in cervical
      lesion detection in the first group of analyzed samples (P = .12), it did affect 
      cervical cancer risk in the group of samples analyzed in the following year (P = 
      .045). HIV-infected patients presented a high prevalence of HPV co-infection, and
      HPV16 and HPV56 were the most prevalent genotypes. Considering this, it is
      possible that immunodeficiency can contribute to increased susceptibility to
      HPV56 infection in HIV-infected patients. The association between HIV viral load 
      and the lesions also confirmed the importance of monitoring HIV/HPV co-infected
      patients with high HIV viral loads.
FAU - Badial, Rodolfo Miglioli
AU  - Badial RM
AD  - Department of Biology, Sao Paulo State University - UNESP, Sao Jose do Rio
      Preto/SP.
FAU - Dias, Marina Carrara
AU  - Dias MC
AD  - Department of Biology, Sao Paulo State University - UNESP, Sao Jose do Rio
      Preto/SP.
FAU - Stuqui, Bruna
AU  - Stuqui B
AD  - Department of Biology, Sao Paulo State University - UNESP, Sao Jose do Rio
      Preto/SP.
FAU - Melli, Patricia Pereira Dos Santos
AU  - Melli PPDS
AD  - Department of Obstetrics and Gynecology, Hospital of Ribeirao Preto School of
      Medicine - HC-FMRP.
FAU - Quintana, Silvana Maria
AU  - Quintana SM
AD  - Department of Gynecology and Obstetrics, Medical School of Ribeirao Preto,
      University of Sao Paulo - USP.
FAU - Bonfim, Caroline Measso do
AU  - Bonfim CMD
AD  - Department of Biology, Sao Paulo State University - UNESP, Sao Jose do Rio
      Preto/SP.
FAU - Cordeiro, Jose Antonio
AU  - Cordeiro JA
AD  - Department of Epidemiology and Public Health, Faculty of Medicine of Sao Jose do 
      Rio Preto - FAMERP, Sao Jose do Rio Preto/SP, Brazil.
FAU - Rabachini, Tatiana
AU  - Rabachini T
AD  - Institute of Pharmacology, University of Bern, Bern, Switzerland.
FAU - Calmon, Marilia de Freitas
AU  - Calmon MF
AD  - Department of Biology, Sao Paulo State University - UNESP, Sao Jose do Rio
      Preto/SP.
FAU - Provazzi, Paola Jocelan Scarin
AU  - Provazzi PJS
AD  - Department of Biology, Sao Paulo State University - UNESP, Sao Jose do Rio
      Preto/SP.
FAU - Rahal, Paula
AU  - Rahal P
AD  - Department of Biology, Sao Paulo State University - UNESP, Sao Jose do Rio
      Preto/SP.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Cervix Uteri/virology
MH  - Coinfection/epidemiology/*virology
MH  - Female
MH  - Genotype
MH  - HIV Infections/epidemiology/*virology
MH  - Human papillomavirus 16/genetics
MH  - Humans
MH  - Middle Aged
MH  - Papillomaviridae/*genetics/growth & development
MH  - Papillomavirus Infections/epidemiology/*virology
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/virology
MH  - Viral Load
EDAT- 2018/04/06 06:00
MHDA- 2018/04/17 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
AID - 10.1097/MD.0000000000009545 [doi]
AID - 00005792-201804060-00047 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(14):e9545. doi: 10.1097/MD.0000000000009545.