PMID- 29622647
OWN - NLM
STAT- MEDLINE
DCOM- 20180411
LR - 20180411
IS - 1095-9203 (Electronic)
IS - 0036-8075 (Linking)
VI - 360
IP - 6384
DP - 2018 Apr 6
TI - CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery
from brain damage.
PG - 50-57
LID - 10.1126/science.aao2300 [doi]
AB - Brain damage such as stroke is a devastating neurological condition that may
severely compromise patient quality of life. No effective medication-mediated
intervention to accelerate rehabilitation has been established. We found that a
small compound, edonerpic maleate, facilitated experience-driven synaptic
glutamate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid)
receptor delivery and resulted in the acceleration of motor function recovery
after motor cortex cryoinjury in mice in a training-dependent manner through
cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2
(CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate
enhanced motor function recovery from internal capsule hemorrhage in nonhuman
primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a
clinically potent small compound with which to accelerate rehabilitation after
brain damage.
CI - Copyright (c) 2018 The Authors, some rights reserved; exclusive licensee American
Association for the Advancement of Science. No claim to original U.S. Government
Works.
FAU - Abe, Hiroki
AU - Abe H
AUID- ORCID: 0000-0001-7441-6664
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Jitsuki, Susumu
AU - Jitsuki S
AUID- ORCID: 0000-0002-0822-4303
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Nakajima, Waki
AU - Nakajima W
AUID- ORCID: 0000-0002-2396-3112
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Murata, Yumi
AU - Murata Y
AUID- ORCID: 0000-0002-6318-2951
AD - Human Informatics Research Institute, National Institute of Advanced Industrial
Science and Technology, Ibaraki, 305-8568, Japan.
FAU - Jitsuki-Takahashi, Aoi
AU - Jitsuki-Takahashi A
AUID- ORCID: 0000-0002-9331-3844
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Katsuno, Yuki
AU - Katsuno Y
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Tada, Hirobumi
AU - Tada H
AUID- ORCID: 0000-0002-6098-7826
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Sano, Akane
AU - Sano A
AUID- ORCID: 0000-0001-7381-031X
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Suyama, Kumiko
AU - Suyama K
AUID- ORCID: 0000-0003-0617-7213
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
FAU - Mochizuki, Nobuyuki
AU - Mochizuki N
AUID- ORCID: 0000-0001-8175-7600
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
AD - Toyama Chemical Co., Tokyo, 160-0023, Japan.
AD - Fujifilm Corporation, Tokyo, 107-0052, Japan.
FAU - Komori, Takashi
AU - Komori T
AUID- ORCID: 0000-0003-3778-2993
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
AD - Toyama Chemical Co., Tokyo, 160-0023, Japan.
AD - Fujifilm Corporation, Tokyo, 107-0052, Japan.
FAU - Masuyama, Hitoshi
AU - Masuyama H
AUID- ORCID: 0000-0002-3501-6796
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan.
AD - Toyama Chemical Co., Tokyo, 160-0023, Japan.
AD - Fujifilm Corporation, Tokyo, 107-0052, Japan.
FAU - Okuda, Tomohiro
AU - Okuda T
AUID- ORCID: 0000-0002-3844-362X
AD - Toyama Chemical Co., Tokyo, 160-0023, Japan.
AD - Fujifilm Corporation, Tokyo, 107-0052, Japan.
FAU - Goshima, Yoshio
AU - Goshima Y
AUID- ORCID: 0000-0002-1944-7051
AD - Yokohama City University Graduate School of Medicine, Department of Molecular
Pharmacology and Neurobiology, Yokohama, 236-0004, Japan.
FAU - Higo, Noriyuki
AU - Higo N
AUID- ORCID: 0000-0002-3448-1696
AD - Human Informatics Research Institute, National Institute of Advanced Industrial
Science and Technology, Ibaraki, 305-8568, Japan.
FAU - Takahashi, Takuya
AU - Takahashi T
AUID- ORCID: 0000-0001-6523-0622
AD - Yokohama City University Graduate School of Medicine, Department of Physiology,
Yokohama, 236-0004, Japan. [email protected]
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
PL - United States
TA - Science
JT - Science (New York, N.Y.)
JID - 0404511
RN - 0 (1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate)
RN - 0 (Intercellular Signaling Peptides and Proteins)
RN - 0 (Maleates)
RN - 0 (Nerve Tissue Proteins)
RN - 0 (Receptors, AMPA)
RN - 0 (Thiophenes)
RN - 0 (collapsin response mediator protein-2)
SB - IM
CIN - Science. 2018 Apr 6;360(6384):30-31. PMID: 29622641
MH - Animals
MH - Brain Injuries/*drug therapy
MH - Intercellular Signaling Peptides and Proteins/*metabolism
MH - Male
MH - Maleates/*metabolism/*pharmacology/therapeutic use
MH - Mice
MH - Mice, Knockout
MH - Mice, Mutant Strains
MH - Motor Cortex/*drug effects/injuries/physiopathology
MH - Nerve Tissue Proteins/*metabolism
MH - Neuronal Plasticity/drug effects
MH - *Neuroprotection
MH - Quality of Life
MH - Receptors, AMPA/metabolism
MH - Recovery of Function/*drug effects
MH - Stroke/complications/drug therapy
MH - Thiophenes/*metabolism/*pharmacology/therapeutic use
EDAT- 2018/04/07 06:00
MHDA- 2018/04/12 06:00
CRDT- 2018/04/07 06:00
PHST- 2017/06/29 00:00 [received]
PHST- 2018/02/01 00:00 [accepted]
PHST- 2018/04/07 06:00 [entrez]
PHST- 2018/04/07 06:00 [pubmed]
PHST- 2018/04/12 06:00 [medline]
AID - 360/6384/50 [pii]
AID - 10.1126/science.aao2300 [doi]
PST - ppublish
SO - Science. 2018 Apr 6;360(6384):50-57. doi: 10.1126/science.aao2300.