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Unilateral macular choroidal neovascularization-a rare manifestation in acute myelocytic leukemia: Case report.

Abstract Characteristic signs of leukemic retinopathy include bilateral intra-retinal hemorrhage, white-centred hemorrhage, macular hemorrhage and cotton-wool spots. Capillary closure, retinal microaneurysms and neovascularization following massive fundus hemorrhage could be involved in few of the above instances. However, single choroidal neovascularization (CNV) in macular has not been observed in acute myelocytic leukemia (AML).
PMID
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Authors

Mayor MeshTerms

Choroidal Neovascularization

Leukemia, Myeloid, Acute

Vision, Low

Keywords
Journal Title medicine
Publication Year Start




PMID- 29668585
OWN - NLM
STAT- MEDLINE
DCOM- 20180425
LR  - 20180502
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 16
DP  - 2018 Apr
TI  - Unilateral macular choroidal neovascularization-a rare manifestation in acute
      myelocytic leukemia: Case report.
PG  - e0344
LID - 10.1097/MD.0000000000010344 [doi]
AB  - RATIONALE: Characteristic signs of leukemic retinopathy include bilateral
      intra-retinal hemorrhage, white-centred hemorrhage, macular hemorrhage and
      cotton-wool spots. Capillary closure, retinal microaneurysms and
      neovascularization following massive fundus hemorrhage could be involved in few
      of the above instances. However, single choroidal neovascularization (CNV) in
      macular has not been observed in acute myelocytic leukemia (AML). PATIENT
      CONCERNS: A 22-year-old woman presented with a 7-day history of vision decline in
      the right eye (OD). The patient was diagnosed as M3 AML one month earlier.
      Chemotherapy was immediately administered, which led to temporary
      myelosuppression. Recent examination showed that best corrected visual acuity was
      20/400 OD. Fundoscopy showed petechial and patchy intra-retinal hemorrhage in
      both eyes and grayish-white lesion in the right macular center, which was
      confirmed as macular CNV by OCT and OCTA. DIAGNOSES: The patient was diagnosed as
      macular CNV OD related to AML and chemotherapeutic regimens. INTERVENTIONS: She
      received intravitreal ranibizumab injection 0.5 mg (10 mg/ml) in the right eye
      for once on January 3, 2017. OUTCOMES: CNV resolved three days after treatment
      with intravitreal ranibizumab injection 0.5 mg for once. No recurrence was
      observed after 10-month follow-up. Vision recovered to 20/40 at the last visit.
      LESSONS: This is the first report demonstrating that macular CNV could be an
      ophthalmic side-effect secondary to initiated chemotherapeutic regimens in
      patients with M3 AML. Intravitreal injection of ranibizumab could be beneficial
      and safe in treating this CNV.
FAU - Yang, Xiaochun
AU  - Yang X
AD  - Department of Ophthalmology, The First People's Hospital of Yunnan Province,
      Ocular Fundus Disease Research Center of Yunnan Province.
FAU - Xu, Jianbiao
AU  - Xu J
AD  - Department of General surgery, The First People's Hospital of Yunnan Province,
      The Affiliated Hospital of Kunming University of Science and Technology, Kunming,
      Yunnan.
FAU - Yang, Jianhui
AU  - Yang J
AD  - Department of Ophthalmology, The First People's Hospital of Yunnan Province,
      Ocular Fundus Disease Research Center of Yunnan Province.
AD  - Department of Ophthalmology, Dali University, Dali.
FAU - Zhou, Yikun
AU  - Zhou Y
AD  - Department of Medicine, The First People's Hospital of Yunnan Province, Kunming
      Yunnan, China.
FAU - Mei, Yan
AU  - Mei Y
AD  - Department of Ophthalmology, The First People's Hospital of Yunnan Province,
      Ocular Fundus Disease Research Center of Yunnan Province.
FAU - Yang, Tonghua
AU  - Yang T
AD  - Department of Medicine, The First People's Hospital of Yunnan Province, Kunming
      Yunnan, China.
FAU - Zhang, Yangmo
AU  - Zhang Y
AD  - Department of Ophthalmology, The First People's Hospital of Yunnan Province,
      Ocular Fundus Disease Research Center of Yunnan Province.
AD  - Department of Ophthalmology, Dali University, Dali.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Angiogenesis Inhibitors)
RN  - ZL1R02VT79 (Ranibizumab)
SB  - AIM
SB  - IM
MH  - Angiogenesis Inhibitors/administration & dosage
MH  - Choroid/blood supply/pathology
MH  - *Choroidal Neovascularization/diagnosis/drug therapy/etiology
MH  - Female
MH  - Humans
MH  - Induction Chemotherapy/*adverse effects/methods
MH  - Intravitreal Injections
MH  - *Leukemia, Myeloid, Acute/complications/diagnosis/drug therapy
MH  - Ophthalmoscopy/methods
MH  - Ranibizumab/*administration & dosage
MH  - Treatment Outcome
MH  - Vision Tests/methods
MH  - *Vision, Low/diagnosis/etiology/therapy
MH  - Young Adult
EDAT- 2018/04/19 06:00
MHDA- 2018/04/26 06:00
CRDT- 2018/04/19 06:00
PHST- 2018/04/19 06:00 [entrez]
PHST- 2018/04/19 06:00 [pubmed]
PHST- 2018/04/26 06:00 [medline]
AID - 10.1097/MD.0000000000010344 [doi]
AID - 00005792-201804200-00011 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(16):e0344. doi: 10.1097/MD.0000000000010344.