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Characterization, treatment and prognosis of retinoblastoma with central nervous system metastasis.

Abstract Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognosis of retinoblastoma patients with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one of the largest tertiary eye centers in China.
PMID
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Authors

Mayor MeshTerms

Retinal Neoplasms

Retinoblastoma

Keywords

Central nervous system metastasis

Pediatric

Retinoblastoma

Journal Title bmc ophthalmology
Publication Year Start




PMID- 29685116
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20180501
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Apr 23
TI  - Characterization, treatment and prognosis of retinoblastoma with central nervous 
      system metastasis.
PG  - 107
LID - 10.1186/s12886-018-0772-8 [doi]
AB  - BACKGROUND: Retinoblastoma is the most common primary intraocular tumor and more 
      and more attention has been paid to the developing countries. This study was
      aimed to evaluate the clinical features, treatment, and prognosis of
      retinoblastoma patients with central nervous system (CNS) metastasis in Beijing
      Tongren Hospital, one of the largest tertiary eye centers in China. METHODS:
      Clinical data of 31 consecutive retinoblastoma patients with CNS metastases, who 
      were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital
      between September 2005 and December 2015, were retrospective analyzed. RESULTS:
      The median age at presentation was 29 months (range from 5 to 108 months).
      Magnetic resonance imaging (MRI) results indicated that 16 patients (56.6%,
      16/31) presented with meningeal involvement, 12 (38.7%, 12/31) presented with
      intracranial mass, 11 (35.5%, 11/31) presented with thickened optic nerve, and 5 
      (16.1%, 5/31) presented with concurrent meningeal and spinal cord membrane
      involvement. Retinoblastoma cells were detected in the cerebrospinal fluid (CSF) 
      of 12 patients (44.4%, 12/27). Laboratory examinations on the blood and CSF were 
      performed for 11 patients who had received six cycles of systemic chemotherapy,
      indicated that the serum level of neurone-specific enolase (NSE) after
      chemotherapy was significantly lower than that before chemotherapy (P < 0.05). At
      the end of the follow-up, 25 patients were dead with a median survival time of 6 
      months (1 d - 21 months), and 6 cases were alive and continued to receive
      treatment. CONCLUSION: Our results were basically consistent with previous
      reports in the developing countries, and it could be guidance for clinical
      treatment, prognosis and prevention of CNS metastases in retinoblastoma.
FAU - Hu, Huimin
AU  - Hu H
AD  - Department of Pediatrics, Beijing Tongren Hospital, West South road 2, Yizhuang
      Economic and Technological Development Zone, Daxing District, Beijing, 100176,
      China.
FAU - Zhang, Weiling
AU  - Zhang W
AD  - Department of Pediatrics, Beijing Tongren Hospital, West South road 2, Yizhuang
      Economic and Technological Development Zone, Daxing District, Beijing, 100176,
      China.
FAU - Wang, Yizhuo
AU  - Wang Y
AD  - Department of Pediatrics, Beijing Tongren Hospital, West South road 2, Yizhuang
      Economic and Technological Development Zone, Daxing District, Beijing, 100176,
      China.
FAU - Huang, Dongsheng
AU  - Huang D
AUID- ORCID: http://orcid.org/0000-0002-6397-4553
AD  - Department of Pediatrics, Beijing Tongren Hospital, West South road 2, Yizhuang
      Economic and Technological Development Zone, Daxing District, Beijing, 100176,
      China. [email protected]
FAU - Shi, Jitong
AU  - Shi J
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical
      University, Beijing, 100176, China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical
      University, Beijing, 100176, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Pediatrics, Beijing Tongren Hospital, West South road 2, Yizhuang
      Economic and Technological Development Zone, Daxing District, Beijing, 100176,
      China.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Department of Pediatrics, Beijing Tongren Hospital, West South road 2, Yizhuang
      Economic and Technological Development Zone, Daxing District, Beijing, 100176,
      China.
LA  - eng
GR  - (No. 2016YNZL04)/Beijing Key Laboratory of Intraocular Tumor Diagnosis and
      Treatment (No. 2016YNZL04)
PT  - Journal Article
DEP - 20180423
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Biomarkers, Tumor/blood
MH  - Central Nervous System Neoplasms/cerebrospinal fluid/drug
      therapy/pathology/*secondary
MH  - Chemoradiotherapy/*methods
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Optic Nerve/pathology
MH  - Prognosis
MH  - *Retinal Neoplasms/drug therapy/pathology
MH  - *Retinoblastoma/cerebrospinal fluid/drug therapy/pathology
MH  - Retrospective Studies
MH  - Survival Analysis
PMC - PMC5914066
OTO - NOTNLM
OT  - Central nervous system metastasis
OT  - Pediatric
OT  - Retinoblastoma
EDAT- 2018/04/25 06:00
MHDA- 2018/05/01 06:00
CRDT- 2018/04/25 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2018/04/13 00:00 [accepted]
PHST- 2018/04/25 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
AID - 10.1186/s12886-018-0772-8 [doi]
AID - 10.1186/s12886-018-0772-8 [pii]
PST - epublish
SO  - BMC Ophthalmol. 2018 Apr 23;18(1):107. doi: 10.1186/s12886-018-0772-8.