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Clinicopathologic characterisitics of pancreatic acinar cell carcinomas.

Abstract Pancreatic acinar cell carcinoma is a rare and relatively indolent malignant tumor with characteristic histopathological and immunohistochemical features. Accurate pathological diagnosis plays an important role in patients' treatment and evaluation of prognosis.
PMID
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Authors

Mayor MeshTerms
Keywords

Carcinoma, acinar cell

Diagnosis, differential

Immunohistochemistry

Pancreatic neoplasms

Journal Title zhonghua bing li xue za zhi = chinese journal of pathology
Publication Year Start




PMID- 29690667
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20180430
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 4
DP  - 2018 Apr 8
TI  - [Clinicopathologic characterisitics of pancreatic acinar cell carcinomas].
PG  - 274-278
LID - 10.3760/cma.j.issn.0529-5807.2018.04.009 [doi]
AB  - Objective: To investigate clinical, pathological and immunohistochemical features
      of pancreatic acinar cell carcinoma. Methods: A retrospective review of surgical 
      and pathological databases between 2011 and 2016 at PLA General Hospital was
      collected and 14 cases of acinar cell carcinoma (ACC) of the pancreas were
      identified. EnVision immunohistochemistry was used to detect the expression of
      Trypsin, bcl-10 and cytokeratin(CK) proteins. Results: The patients included nine
      cases of pure ACC, 3 cases of mixed acinar ductal carcinoma, 1 case of mixed
      acinar-neuroendocrine carcinoma and acinar-ductal-neuroendocrine carcinoma,
      respectively. Tumors involved different anatomic locations of the pancreas,
      including eight involving the head of pancreas, four in the body and tail, one in
      the uncinate process and one in a heterotopic pancreas. Two patients had lymph
      node and liver metastases before surgery. Microscopically, the tumor was
      hypercellular with less fibroblastic proliferation and tumor cells arranged in
      acinar or solid pattern. The well differentiated tumor cells showed eosinophilic,
      granular cytoplasm with single prominent nucleoli, while the poorly
      differentiated tumor cells tended to grow in solid sheets. Immunohistochemically,
      the tumor cells were positive for pan-cytokeratin (14/14), Trypsin (12/14) and
      bcl-10 (11/14). Stains for CK7 and CK19 were negative (11/14 and 3/4). According 
      to the pTNM staging, there were 7 cases at stage, 3 at stage A, 3 at stage and 1 
      at stage . With average postoperative follow-up of 6-58 months, the median
      disease-free survival time was 16 months. Conclusions: Pancreatic acinar cell
      carcinoma is a rare and relatively indolent malignant tumor with characteristic
      histopathological and immunohistochemical features. Accurate pathological
      diagnosis plays an important role in patients' treatment and evaluation of
      prognosis.
FAU - Ding, X H
AU  - Ding XH
AD  - Department of Pathology, PLA General Hospital, Beijing 100853, China.
FAU - Wang, Z B
AU  - Wang ZB
FAU - Qiu, X M
AU  - Qiu XM
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 68238-35-7 (Keratins)
RN  - Pancreatic Carcinoma
SB  - IM
MH  - Carcinoma, Acinar Cell/metabolism/*pathology
MH  - Carcinoma, Neuroendocrine/metabolism/*pathology
MH  - Cell Proliferation
MH  - Disease-Free Survival
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratins/metabolism
MH  - Pancreas/pathology
MH  - Pancreatic Neoplasms/metabolism/*pathology
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Carcinoma, acinar cell
OT  - Diagnosis, differential
OT  - Immunohistochemistry
OT  - Pancreatic neoplasms
EDAT- 2018/04/25 06:00
MHDA- 2018/05/01 06:00
CRDT- 2018/04/26 06:00
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Apr 8;47(4):274-278.