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The state of the art research findings on the relationship between chronic periodontitis and Alzheimer's disease: a review.

Abstract Along with the development of periodontal medicine, there is a growing number of evidence showing that periodontitis could influence systemic health. Periodontitis is a chronic inflammatory disease caused by microbial infection mediated by dental plaque. Periodontal pathogenic microorganisms and its toxic products can disseminate through the blood stream or may cause the host immune response, which may lead to pathological changes of cerebral vessels and brain tissues to establish connection with Alzheimer's disease (AD). AD is a progressive neurodegenerative disease characterized by progressive memory loss, language and cognitive dysfunction. This article reviewed the association between chronic periodontitis and AD.
PMID
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Authors

Mayor MeshTerms
Keywords

Alzheimer's disease

Inflammation

Periodontitis

Periodontopathic microorganisms

Journal Title zhonghua kou qiang yi xue za zhi = zhonghua kouqiang yixue zazhi = chinese journal of stomatology
Publication Year Start




PMID- 29690700
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20180501
IS  - 1002-0098 (Print)
IS  - 1002-0098 (Linking)
VI  - 53
IP  - 4
DP  - 2018 Apr 9
TI  - [The state of the art research findings on the relationship between chronic
      periodontitis and Alzheimer's disease: a review].
PG  - 275-279
LID - 10.3760/cma.j.issn.1002-0098.2018.04.012 [doi]
AB  - Along with the development of periodontal medicine, there is a growing number of 
      evidence showing that periodontitis could influence systemic health.
      Periodontitis is a chronic inflammatory disease caused by microbial infection
      mediated by dental plaque. Periodontal pathogenic microorganisms and its toxic
      products can disseminate through the blood stream or may cause the host immune
      response, which may lead to pathological changes of cerebral vessels and brain
      tissues to establish connection with Alzheimer's disease (AD). AD is a
      progressive neurodegenerative disease characterized by progressive memory loss,
      language and cognitive dysfunction. This article reviewed the association between
      chronic periodontitis and AD.
FAU - Qian, X S
AU  - Qian XS
AD  - Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, 
      Zunyi Guizhou 563000, China.
FAU - Ge, S
AU  - Ge S
AD  - Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, 
      Zunyi Guizhou 563000, China.
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Kou Qiang Yi Xue Za Zhi
JT  - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese
      journal of stomatology
JID - 8711066
SB  - D
SB  - IM
MH  - Alzheimer Disease/*etiology
MH  - Brain/blood supply
MH  - Cerebral Arteries/pathology
MH  - Cerebral Veins/pathology
MH  - Chronic Periodontitis/*complications/immunology/microbiology
MH  - Humans
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Inflammation
OT  - Periodontitis
OT  - Periodontopathic microorganisms
EDAT- 2018/04/25 06:00
MHDA- 2018/05/02 06:00
CRDT- 2018/04/26 06:00
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PST - ppublish
SO  - Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Apr 9;53(4):275-279.