PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Microsurgery for patients diagnosed with neurofibromatosis type 2 complicated by vestibular schwannomas: Clinical experience and strategy for treatments.

Abstract Most patients diagnosed with neurofibromatosis type 2 (NF2) have bilateral vestibular schwannomas (VS). Through reviewing surgical method and clinical outcomes, we tried to find out a strategy for treatments in NF2 patients with VS.We retrospectively reviewed patients diagnosed pathological NF2 and have had microsurgery (MS) for VS in the PLA Army General Hospital. Seventeen patients were included from January 2000 to December 2016. Fifteen patients had progressive hearing impairment, and 7 ears were totally deaf. Computed tomography and magnetic resonance imaging were used for preoperative and postoperative evaluation. House-Brackmann (H-B) classification was used to evaluate facial function, and the hearing outcome was classified according to American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) hearing classification system. The outcomes included functional hearing, facial function, and complications.In the 17 patients, 9 were men, and the mean age was 27.2 years old. The mean duration of disease was 38.4 months. Twenty-six VS were excised. Nine patients with bilateral VS and unilateral surgery had repeated surgery for the contralateral tumor after 3 to 12 months. The hearing preservation rate was 41.6%. In the 26 excisions for VS, 24 had intact facial nerve. In the other 2 tumor excision, damaged facial nerves had head-to-head adhesion using biological fibrin glue. The rate of facial nerve function preservation was 60%. No mortality or major complication was reported. The follow-up time ranged from 11 to 78 months with a mean value of 39 months.MS is an effective treatment for NF2 patients with VS. The operation for bilateral VS should be staged according to tumor size and bilateral hearing function. However, methods on how to preserve functional hearing and facial function remain the issue. Further randomized controlled studies are needed to find out a better treatment for NF2 patients with VS according to the overall condition.
PMID
Related Publications

Outcome on hearing and facial nerve function in microsurgical treatment of small vestibular schwannoma via the middle cranial fossa approach.

Linear accelerator-based stereotactic radiosurgery for bilateral vestibular schwannomas in patients with neurofibromatosis type 2.

Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2.

Management of vestibular schwannomas (acoustic neuromas): auditory and facial nerve function after resection of 120 vestibular schwannomas in patients with neurofibromatosis 2.

Surgical management of vestibular schwannomas and hearing rehabilitation in neurofibromatosis type 2.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29702972
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20180516
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 17
DP  - 2018 Apr
TI  - Microsurgery for patients diagnosed with neurofibromatosis type 2 complicated by 
      vestibular schwannomas: Clinical experience and strategy for treatments.
PG  - e0270
LID - 10.1097/MD.0000000000010270 [doi]
AB  - Most patients diagnosed with neurofibromatosis type 2 (NF2) have bilateral
      vestibular schwannomas (VS). Through reviewing surgical method and clinical
      outcomes, we tried to find out a strategy for treatments in NF2 patients with
      VS.We retrospectively reviewed patients diagnosed pathological NF2 and have had
      microsurgery (MS) for VS in the PLA Army General Hospital. Seventeen patients
      were included from January 2000 to December 2016. Fifteen patients had
      progressive hearing impairment, and 7 ears were totally deaf. Computed tomography
      and magnetic resonance imaging were used for preoperative and postoperative
      evaluation. House-Brackmann (H-B) classification was used to evaluate facial
      function, and the hearing outcome was classified according to American Academy of
      Otolaryngology-Head and Neck Surgery (AAO-HNS) hearing classification system. The
      outcomes included functional hearing, facial function, and complications.In the
      17 patients, 9 were men, and the mean age was 27.2 years old. The mean duration
      of disease was 38.4 months. Twenty-six VS were excised. Nine patients with
      bilateral VS and unilateral surgery had repeated surgery for the contralateral
      tumor after 3 to 12 months. The hearing preservation rate was 41.6%. In the 26
      excisions for VS, 24 had intact facial nerve. In the other 2 tumor excision,
      damaged facial nerves had head-to-head adhesion using biological fibrin glue. The
      rate of facial nerve function preservation was 60%. No mortality or major
      complication was reported. The follow-up time ranged from 11 to 78 months with a 
      mean value of 39 months.MS is an effective treatment for NF2 patients with VS.
      The operation for bilateral VS should be staged according to tumor size and
      bilateral hearing function. However, methods on how to preserve functional
      hearing and facial function remain the issue. Further randomized controlled
      studies are needed to find out a better treatment for NF2 patients with VS
      according to the overall condition.
FAU - Chen, Li-Hua
AU  - Chen LH
AD  - Department of Neurosurgery, The Affiliated Bayi Brain Hospital, The PLA Army
      General Hospital, Beijing, China.
FAU - Zhang, Hong-Tian
AU  - Zhang HT
FAU - Xu, Ru-Xiang
AU  - Xu RX
FAU - Zhang, Li
AU  - Zhang L
FAU - Li, Wen-De
AU  - Li WD
FAU - Sun, Kai
AU  - Sun K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Microsurgery/*methods
MH  - Neurofibromatosis 2/complications/diagnostic imaging/*surgery
MH  - Neuroma, Acoustic/complications/diagnostic imaging/*surgery
MH  - Otologic Surgical Procedures/*methods
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC5944529
EDAT- 2018/04/29 06:00
MHDA- 2018/05/15 06:00
CRDT- 2018/04/29 06:00
PHST- 2018/04/29 06:00 [entrez]
PHST- 2018/04/29 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
AID - 10.1097/MD.0000000000010270 [doi]
AID - 00005792-201804270-00004 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(17):e0270. doi: 10.1097/MD.0000000000010270.