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Associations between bone-alkaline phosphatase and bone mineral density in adults with and without diabetes.

Abstract Insufficient evidence is available to reliably compare the roles of bone alkaline phosphatase (BAP) and bone mineral density (BMD) in diabetes. This study aimed to compare associations between BAP and BMD in adults with and without diabetes to elucidate fracture risk in diabetes.Data were extracted from the National Health and Nutrition Examination Survey (NHANES), 2001-2004, including 4197 adults aged 20 to 49 years, 143 with diabetes (DM group), and 4054 without (non-DM group). Main outcome measure was BMD and regression analyses were performed to identify serum BAP and other covariates associated with total BMD.BMD decreased significantly in DM patients when BAP was increased. In the non-DM group, all BMD results were significantly decreased when BAP was increased. Factors associated with total BMD varied with DM status. Lifestyle measures such as smoking and physical activity were also associated with BMD in the non-DM group.BAP and BMD are inversely associated in DM and non-DM patients. BAP is significantly associated with BMD after controlling for other variables, suggesting that BAP may interact with other factors altering bone metabolism in DM patients.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29702995
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20180516
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 17
DP  - 2018 Apr
TI  - Associations between bone-alkaline phosphatase and bone mineral density in adults
      with and without diabetes.
PG  - e0432
LID - 10.1097/MD.0000000000010432 [doi]
AB  - Insufficient evidence is available to reliably compare the roles of bone alkaline
      phosphatase (BAP) and bone mineral density (BMD) in diabetes. This study aimed to
      compare associations between BAP and BMD in adults with and without diabetes to
      elucidate fracture risk in diabetes.Data were extracted from the National Health 
      and Nutrition Examination Survey (NHANES), 2001-2004, including 4197 adults aged 
      20 to 49 years, 143 with diabetes (DM group), and 4054 without (non-DM group).
      Main outcome measure was BMD and regression analyses were performed to identify
      serum BAP and other covariates associated with total BMD.BMD decreased
      significantly in DM patients when BAP was increased. In the non-DM group, all BMD
      results were significantly decreased when BAP was increased. Factors associated
      with total BMD varied with DM status. Lifestyle measures such as smoking and
      physical activity were also associated with BMD in the non-DM group.BAP and BMD
      are inversely associated in DM and non-DM patients. BAP is significantly
      associated with BMD after controlling for other variables, suggesting that BAP
      may interact with other factors altering bone metabolism in DM patients.
FAU - Chen, Hailing
AU  - Chen H
FAU - Li, Jufen
AU  - Li J
FAU - Wang, Qian
AU  - Wang Q
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Alcohol Drinking/epidemiology
MH  - Alkaline Phosphatase/*blood
MH  - Biomarkers
MH  - Bone Density/*physiology
MH  - Bone and Bones/*metabolism
MH  - Comorbidity
MH  - Continental Population Groups
MH  - Diabetes Mellitus/epidemiology/*physiopathology
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
MH  - Smoking/epidemiology
MH  - Young Adult
PMC - PMC5944480
EDAT- 2018/04/29 06:00
MHDA- 2018/05/15 06:00
CRDT- 2018/04/29 06:00
PHST- 2018/04/29 06:00 [entrez]
PHST- 2018/04/29 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
AID - 10.1097/MD.0000000000010432 [doi]
AID - 00005792-201804270-00027 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(17):e0432. doi: 10.1097/MD.0000000000010432.