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Immunological markers as predictors of developing steroid-induced diabetes mellitus in pemphigus vulgaris patients: An observational study.

Abstract The aim of this study was to evaluate the clinical importance of autoantibodies in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus (SID) because of the glucocorticoid therapy of pemphigus.A total of 137 patients with pemphigus vulgaris were studied. Patients with SID and pemphigus were compared with those that had only pemphigus. The variables recorded were: age at diagnosis, sex, body mass index, presence of diabetes mellitus (DM), cumulative cortisone dose, treatment duration, value of anti-desmoglein 1 and 3, and anti-glutamic acid decarboxylase autoantibodies.A total of 31 patients (22.62%) that developed steroid-induced DM were identified. Anti-glutamic acid decarboxylase autoantibodies were positive in 20.75% of patients with pemphigus vulgaris and in 25.75% of patients with pemphigus vulgaris and SID.The overall anti-glutamic acid decarboxylase autoantibodies prevalence in pemphigus patients was high, and the risk of developing DM in patients with pemphigus remains a serious problem, being associated with increased risk of mortality.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29702999
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20180516
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 17
DP  - 2018 Apr
TI  - Immunological markers as predictors of developing steroid-induced diabetes
      mellitus in pemphigus vulgaris patients: An observational study.
PG  - e0463
LID - 10.1097/MD.0000000000010463 [doi]
AB  - The aim of this study was to evaluate the clinical importance of autoantibodies
      in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus
      (SID) because of the glucocorticoid therapy of pemphigus.A total of 137 patients 
      with pemphigus vulgaris were studied. Patients with SID and pemphigus were
      compared with those that had only pemphigus. The variables recorded were: age at 
      diagnosis, sex, body mass index, presence of diabetes mellitus (DM), cumulative
      cortisone dose, treatment duration, value of anti-desmoglein 1 and 3, and
      anti-glutamic acid decarboxylase autoantibodies.A total of 31 patients (22.62%)
      that developed steroid-induced DM were identified. Anti-glutamic acid
      decarboxylase autoantibodies were positive in 20.75% of patients with pemphigus
      vulgaris and in 25.75% of patients with pemphigus vulgaris and SID.The overall
      anti-glutamic acid decarboxylase autoantibodies prevalence in pemphigus patients 
      was high, and the risk of developing DM in patients with pemphigus remains a
      serious problem, being associated with increased risk of mortality.
FAU - Danescu, Ana Sorina
AU  - Danescu AS
AD  - Department of Dermatology.
FAU - Baldea, Ioana
AU  - Baldea I
AD  - Department of Physiology.
FAU - Leucuta, Daniel Corneliu
AU  - Leucuta DC
AD  - Department of Medical Informatics and Biostatistics, Iuliu Hatieganu University
      of Medicine and Pharmacy.
FAU - Lupan, Iulia
AU  - Lupan I
AD  - Department of Molecular Biology, Babes-Bolyai University.
FAU - Samasca, Gabriel
AU  - Samasca G
AD  - Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy,
      Cluj-Napoca, Romania.
FAU - Sitaru, Cassian
AU  - Sitaru C
AD  - Department of Dermatology, University Medical Center Freiburg, Center for
      Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany.
FAU - Chiorean, Roxana
AU  - Chiorean R
AD  - Department of Dermatology.
FAU - Baican, Adrian
AU  - Baican A
AD  - Department of Dermatology.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Desmoglein 1)
RN  - 0 (Desmoglein 3)
RN  - 0 (Glucocorticoids)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies/*immunology
MH  - Biomarkers
MH  - Body Mass Index
MH  - Desmoglein 1/immunology
MH  - Desmoglein 3/immunology
MH  - Diabetes Mellitus/*chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glucocorticoids/*adverse effects/therapeutic use
MH  - Glutamate Decarboxylase/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/*drug therapy/*immunology
MH  - Sex Factors
MH  - Young Adult
PMC - PMC5944517
EDAT- 2018/04/29 06:00
MHDA- 2018/05/15 06:00
CRDT- 2018/04/29 06:00
PHST- 2018/04/29 06:00 [entrez]
PHST- 2018/04/29 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
AID - 10.1097/MD.0000000000010463 [doi]
AID - 00005792-201804270-00031 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(17):e0463. doi: 10.1097/MD.0000000000010463.