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Multiple unexpected lesions of metachondromatosis detected by technetium-99m methylene diphosphonate SPECT/CT: A case report.

Abstract Metachondromatosis (MC) is a very rare genetic disease, which is infrequently reported worldwide, which leads to osteochondroma and enchondromatosis. The disease has been shown to be associated with loss of function of the tumor suppressor gene "protein tyrosine phosphatase, non-receptor type 11" (PTPN11).
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start

 



PMID- 29703018
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20180516
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 17
DP  - 2018 Apr
TI  - Multiple unexpected lesions of metachondromatosis detected by technetium-99m
      methylene diphosphonate SPECT/CT: A case report.
PG  - e0512
LID - 10.1097/MD.0000000000010512 [doi]
AB  - RATIONALE: Metachondromatosis (MC) is a very rare genetic disease, which is
      infrequently reported worldwide, which leads to osteochondroma and
      enchondromatosis. The disease has been shown to be associated with loss of
      function of the tumor suppressor gene "protein tyrosine phosphatase, non-receptor
      type 11" (PTPN11). PATIENT CONCERNS: A 12-year-old female was admitted to the
      hospital with pain due to an enlarged mass in her left fifth finger. DIAGNOSIS:
      Examination of the left hand by computed tomography (CT) revealed an expanding
      type of round and low-density lesion in the fifth proximal phalanx. The patient
      then underwent technetium-99m methylene diphosphonate single-photon emission
      CT/CT (Tc-MDP SPECT/CT) to assess the nature of the lesion. The SPECT/CT image
      revealed dilated osteopathy and increased activity of the fifth proximal phalanx 
      on the left hand. Unexpectedly, the examination of the right hand revealed slight
      expanded lesions and increased activities of the third metacarpal and proximal
      phalange, as well as the fourth proximal phalange and the middle phalanx. On the 
      basis of the patient's symptoms and the results of the above-mentioned
      examinations, we diagnosed the patient as having MC in her hands. INTERVENTION:
      Considering the pain of the fifth finger of the left hand, the patient underwent 
      debridement of the fifth proximal phalanx of the left hand and internal fixation 
      with bone graft taken from the body. OUTCOMES: The patient was discharged after a
      week of observation. One year later, she was admitted to the hospital again for
      removal of the bone healing internal fixation after osteoma surgery. Preoperative
      Tc-MDP SPECT/CT revealed that the left-handed lesions displayed postoperative
      changes, while the multiple lesions in the right hand increased in volume but
      remained unchanged in number. LESSONS: This case revealed the CT and Tc-MDP
      SPECT/CT imaging features of MC. Specifically, SPECT/CT imaging contributed to
      the diagnosis of clinically asymptomatic bone lesions, and the 3D SPECT/CT fusion
      allowed a more comprehensive and intuitive view of the lesion by combining
      anatomy and function.
FAU - Wang, Zi
AU  - Wang Z
AD  - Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical
      University.
FAU - Zou, Yuting
AU  - Zou Y
AD  - Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical
      University.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Radiology, The Affiliated TCM Hospital of Southwest Medical
      University, Luzhou, Sichuan, China.
FAU - Chen, Yue
AU  - Chen Y
AD  - Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical
      University.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - X89XV46R07 (Technetium Tc 99m Medronate)
RN  - Metachondromatosis
SB  - AIM
SB  - IM
MH  - Bone Neoplasms/*diagnostic imaging/surgery
MH  - Child
MH  - Chondromatosis/*diagnostic imaging/surgery
MH  - Exostoses, Multiple Hereditary/*diagnostic imaging/surgery
MH  - Female
MH  - Finger Phalanges/*diagnostic imaging/surgery
MH  - Humans
MH  - Single Photon Emission Computed Tomography Computed Tomography/*methods
MH  - Technetium Tc 99m Medronate
PMC - PMC5944487
EDAT- 2018/04/29 06:00
MHDA- 2018/05/15 06:00
CRDT- 2018/04/29 06:00
PHST- 2018/04/29 06:00 [entrez]
PHST- 2018/04/29 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
AID - 10.1097/MD.0000000000010512 [doi]
AID - 00005792-201804270-00050 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Apr;97(17):e0512. doi: 10.1097/MD.0000000000010512.