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Antidiabetic Naphthoquinones and Their Plant Resources in Thailand.

Abstract Diabetes mellitus is the seventh leading cause of death globally. Ninety percent of the diabetic population suffers from type-2 diabetes, which still needs an effective, safe and economical oral hypoglycemic therapy. Plants are rich sources of various therapeutic molecules. More than 400 medicinal plants of interesting phytochemical diversity have been reported for their antidiabetic potential. Naphthoquinones are a group of phytochemicals, which have a wide range of pharmacological potential, including antidiabetic activity. Naphthoquinones exert their antidiabetic effects through various mechanisms such as the inhibition of α-glucosidase and protein tyrosine phosphatase 1B, increased glucose uptake in myocytes and adipocytes via glucose transporter type 4 (GLUT4) and GLUT2 translocations, enhanced peroxisome proliferator-activated receptor gamma (PPARγ) ligand activity, and by normalizing carbohydrate metabolizing enzymes in the liver. Moreover, naphthoquinone inhibits adipogenesis by both upstream and downstream regulation to control obesity, which is one of the important risk factors for diabetes. Naturally occurring naphthoquinones, as well as their plant sources, are therefore of interest for exploring their antidiabetic potential. The present review aims to overview the antidiabetic potential of naphthoquinones and their plant resources in Thailand.
PMID
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Authors

Mayor MeshTerms
Keywords

adipogenesis

hypoglycemic

medicinal plant

naphthoquinone

obesity

Journal Title chemical & pharmaceutical bulletin
Publication Year Start




PMID- 29710045
OWN - NLM
STAT- MEDLINE
DCOM- 20180516
LR  - 20180516
IS  - 1347-5223 (Electronic)
IS  - 0009-2363 (Linking)
VI  - 66
IP  - 5
DP  - 2018
TI  - Antidiabetic Naphthoquinones and Their Plant Resources in Thailand.
PG  - 483-492
LID - 10.1248/cpb.c17-00529 [doi]
AB  - Diabetes mellitus is the seventh leading cause of death globally. Ninety percent 
      of the diabetic population suffers from type-2 diabetes, which still needs an
      effective, safe and economical oral hypoglycemic therapy. Plants are rich sources
      of various therapeutic molecules. More than 400 medicinal plants of interesting
      phytochemical diversity have been reported for their antidiabetic potential.
      Naphthoquinones are a group of phytochemicals, which have a wide range of
      pharmacological potential, including antidiabetic activity. Naphthoquinones exert
      their antidiabetic effects through various mechanisms such as the inhibition of
      alpha-glucosidase and protein tyrosine phosphatase 1B, increased glucose uptake
      in myocytes and adipocytes via glucose transporter type 4 (GLUT4) and GLUT2
      translocations, enhanced peroxisome proliferator-activated receptor gamma
      (PPARgamma) ligand activity, and by normalizing carbohydrate metabolizing enzymes
      in the liver. Moreover, naphthoquinone inhibits adipogenesis by both upstream and
      downstream regulation to control obesity, which is one of the important risk
      factors for diabetes. Naturally occurring naphthoquinones, as well as their plant
      sources, are therefore of interest for exploring their antidiabetic potential.
      The present review aims to overview the antidiabetic potential of naphthoquinones
      and their plant resources in Thailand.
FAU - Shah, Muhammad Ajmal
AU  - Shah MA
AD  - Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical 
      Sciences, Prince of Songkla University.
FAU - Keach, James E
AU  - Keach JE
AD  - Research and Horticulture Department, Gardens by the Bay.
FAU - Panichayupakaranant, Pharkphoom
AU  - Panichayupakaranant P
AD  - Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical 
      Sciences, Prince of Songkla University.
AD  - Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of
      Pharmaceutical Sciences, Prince of Songkla University.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Naphthoquinones)
RN  - 0 (Plant Extracts)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
RN  - EC 3.2.1.20 (alpha-Glucosidases)
SB  - IM
MH  - Adipogenesis/drug effects
MH  - Animals
MH  - Diabetes Mellitus/*drug therapy
MH  - Enzyme Inhibitors/chemistry/isolation & purification/*pharmacology
MH  - Humans
MH  - Hypoglycemic Agents/chemistry/isolation & purification/*pharmacology
MH  - Naphthoquinones/chemistry/isolation & purification/*pharmacology
MH  - Obesity/drug therapy
MH  - Plant Extracts/chemistry/isolation & purification/*pharmacology
MH  - Plants, Medicinal/*chemistry
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists &
      inhibitors/metabolism
MH  - Thailand
MH  - alpha-Glucosidases/metabolism
OTO - NOTNLM
OT  - adipogenesis
OT  - hypoglycemic
OT  - medicinal plant
OT  - naphthoquinone
OT  - obesity
EDAT- 2018/05/02 06:00
MHDA- 2018/05/17 06:00
CRDT- 2018/05/01 06:00
PHST- 2018/05/01 06:00 [entrez]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2018/05/17 06:00 [medline]
AID - 10.1248/cpb.c17-00529 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2018;66(5):483-492. doi: 10.1248/cpb.c17-00529.