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Biomechanical and Histologic Evaluation of LifeMesh™: A Novel Self-Fixating Mesh Adhesive.

Abstract Mesh fixation with the use of adhesives results in an immediate and total surface area adhesion of the mesh, removing the need for penetrating fixation points. The purpose of this study was to evaluate LifeMesh™, a prototype mesh adhesive technology which coats polypropylene mesh. The strength of the interface between mesh and tissue, inflammatory responses, and histology were measured at varying time points in a swine model, and these results were compared with sutures. Twenty Mongrel swine underwent implantation of LifeMesh™ and one piece of bare polypropylene mesh secured with suture (control). One additional piece of either LifeMesh™ or control was used for histopathologic evaluation. The implants were retrieved at 3, 7, and 14 days. Only 3- and 7-day specimens underwent lap shear testing. On Day 3, LifeMesh™ samples showed considerably less contraction than sutured samples. The interfacial strength of Day 3 LifeMesh™ samples was similar to that of sutured samples. At seven days, LifeMesh™ samples continued to show significantly less contraction than sutured samples. The strength of fixation at seven days was greater in the control samples. The histologic findings were similar in LifeMesh™ and control samples. LifeMesh™ showed significantly less contraction than sutured samples at all measured time points. Although fixation strength was similar at three days, the interfacial strength of LifeMesh™ remained unchanged, whereas sutured controls increased by day 7. With histologic equivalence, considerably less contraction, and similar early fixation strength, LifeMesh™ is a viable mesh fixation technology.
PMID
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Authors

Mayor MeshTerms

Surgical Mesh

Tissue Adhesives

Keywords
Journal Title the american surgeon
Publication Year Start




PMID- 29712599
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20180509
IS  - 1555-9823 (Electronic)
IS  - 0003-1348 (Linking)
VI  - 84
IP  - 4
DP  - 2018 Apr 1
TI  - Biomechanical and Histologic Evaluation of LifeMesh: A Novel Self-Fixating Mesh
      Adhesive.
PG  - 520-525
AB  - Mesh fixation with the use of adhesives results in an immediate and total surface
      area adhesion of the mesh, removing the need for penetrating fixation points. The
      purpose of this study was to evaluate LifeMesh, a prototype mesh adhesive
      technology which coats polypropylene mesh. The strength of the interface between 
      mesh and tissue, inflammatory responses, and histology were measured at varying
      time points in a swine model, and these results were compared with sutures.
      Twenty Mongrel swine underwent implantation of LifeMesh and one piece of bare
      polypropylene mesh secured with suture (control). One additional piece of either 
      LifeMesh or control was used for histopathologic evaluation. The implants were
      retrieved at 3, 7, and 14 days. Only 3- and 7-day specimens underwent lap shear
      testing. On Day 3, LifeMesh samples showed considerably less contraction than
      sutured samples. The interfacial strength of Day 3 LifeMesh samples was similar
      to that of sutured samples. At seven days, LifeMesh samples continued to show
      significantly less contraction than sutured samples. The strength of fixation at 
      seven days was greater in the control samples. The histologic findings were
      similar in LifeMesh and control samples. LifeMesh showed significantly less
      contraction than sutured samples at all measured time points. Although fixation
      strength was similar at three days, the interfacial strength of LifeMesh remained
      unchanged, whereas sutured controls increased by day 7. With histologic
      equivalence, considerably less contraction, and similar early fixation strength, 
      LifeMesh is a viable mesh fixation technology.
FAU - Shahan, Charles P
AU  - Shahan CP
FAU - Stoikes, Nathaniel N
AU  - Stoikes NN
FAU - Roan, Esra
AU  - Roan E
FAU - Tatum, James
AU  - Tatum J
FAU - Webb, David L
AU  - Webb DL
FAU - Voeller, Guy R
AU  - Voeller GR
LA  - eng
PT  - Evaluation Studies
PT  - Journal Article
PL  - United States
TA  - Am Surg
JT  - The American surgeon
JID - 0370522
RN  - 0 (Polypropylenes)
RN  - 0 (Tissue Adhesives)
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Foreign-Body Reaction/*pathology
MH  - Herniorrhaphy/adverse effects/*instrumentation/methods
MH  - Male
MH  - Polypropylenes
MH  - *Surgical Mesh/adverse effects
MH  - Sutures
MH  - Swine
MH  - *Tissue Adhesives/adverse effects
EDAT- 2018/05/02 06:00
MHDA- 2018/05/10 06:00
CRDT- 2018/05/02 06:00
PHST- 2018/05/02 06:00 [entrez]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
PST - ppublish
SO  - Am Surg. 2018 Apr 1;84(4):520-525.