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Synchronous Pancreatic Ductal Adenocarcinoma and Hepatocellular Carcinoma: Report of a Case and Review of the Literature.

Abstract Two or more histologically distinct malignancies diagnosed during the same hospital admission are uncommon, but they do exist. Cases with synchronous primary pancreatic ductal adenocarcinoma and hepatocellular carcinoma are rarely seen. This is a case report of a 56 years old Caucasian female with the chief complaint of jaundice over a duration of 10 days. CT imaging findings revealed a 3.5 cm ill-defined pancreatic head mass and a 1.5 cm liver mass in the segment 5. EUS-FNA cytology showed pancreatic head ductal adenocarcinoma (PDAC). Liver biopsy revealed a well differentiated hepatocellular carcinoma (HCC). The patient underwent a pancreaticoduodenectomy and the pathology revealed a pancreatic ductal adenocarcinoma extending into peripancreatic soft tissue, portal vein and vascular groove with perineural invasion. This is a unique and challenging case with the coexistence of a primary PDAC and a primary HCC. To the best of our knowledge, this is the first documented case of synchronous PDAC and HCC in the English literature. The diagnosis and treatment of the two entities are discussed.
PMID
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Authors

Mayor MeshTerms
Keywords

Synchronous carcinomas

endoscopic ultrasound guided fine needle aspiration (EUS-FNA)

hepatocellular carcinoma

pancreatic ductal adenocarcinoma

Journal Title anticancer research
Publication Year Start




PMID- 29715132
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20180508
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 5
DP  - 2018 May
TI  - Synchronous Pancreatic Ductal Adenocarcinoma and Hepatocellular Carcinoma: Report
      of a Case and Review of the Literature.
PG  - 3009-3012
AB  - Two or more histologically distinct malignancies diagnosed during the same
      hospital admission are uncommon, but they do exist. Cases with synchronous
      primary pancreatic ductal adenocarcinoma and hepatocellular carcinoma are rarely 
      seen. This is a case report of a 56 years old Caucasian female with the chief
      complaint of jaundice over a duration of 10 days. CT imaging findings revealed a 
      3.5 cm ill-defined pancreatic head mass and a 1.5 cm liver mass in the segment 5.
      EUS-FNA cytology showed pancreatic head ductal adenocarcinoma (PDAC). Liver
      biopsy revealed a well differentiated hepatocellular carcinoma (HCC). The patient
      underwent a pancreaticoduodenectomy and the pathology revealed a pancreatic
      ductal adenocarcinoma extending into peripancreatic soft tissue, portal vein and 
      vascular groove with perineural invasion. This is a unique and challenging case
      with the coexistence of a primary PDAC and a primary HCC. To the best of our
      knowledge, this is the first documented case of synchronous PDAC and HCC in the
      English literature. The diagnosis and treatment of the two entities are
      discussed.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Lai, Jenny Z
AU  - Lai JZ
AD  - University College, Washington University in St. Louis, St. Louis, MO, U.S.A.
AD  - Department of Pathology and Immunology, Washington University in Saint Louis
      School of Medicine, St. Louis, MO, U.S.A.
FAU - Zhou, Yihua
AU  - Zhou Y
AD  - Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh,
      PA, U.S.A.
FAU - Cao, Dengfeng
AU  - Cao D
AD  - Department of Pathology and Immunology, Washington University in Saint Louis
      School of Medicine, St. Louis, MO, U.S.A. [email protected]
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Carcinoma, Hepatocellular/*pathology
MH  - Carcinoma, Pancreatic Ductal/*pathology
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*pathology
MH  - Middle Aged
MH  - Neoplasms, Multiple Primary/*pathology
MH  - Pancreatic Neoplasms/*pathology
OTO - NOTNLM
OT  - *Synchronous carcinomas
OT  - *endoscopic ultrasound guided fine needle aspiration (EUS-FNA)
OT  - *hepatocellular carcinoma
OT  - *pancreatic ductal adenocarcinoma
EDAT- 2018/05/02 06:00
MHDA- 2018/05/09 06:00
CRDT- 2018/05/02 06:00
PHST- 2018/03/10 00:00 [received]
PHST- 2018/03/27 00:00 [revised]
PHST- 2018/03/28 00:00 [accepted]
PHST- 2018/05/02 06:00 [entrez]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
AID - 38/5/3009 [pii]
AID - 10.21873/anticanres.12554 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 May;38(5):3009-3012. doi: 10.21873/anticanres.12554.