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Association of Foxp3 promoter polymorphisms with susceptibility to endometrial cancer in the Chinese Han women.

Abstract To evaluate the association between Foxp3 gene polymorphisms (rs3761548 and rs5902434) and susceptibility to endometrial cancer (EC), we report a hospital case-control study involving 602 women, consisting of 269 patients with EC and 333 healthy controls. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Our results suggest that the frequency of the A allele in rs3761548 in patients with EC was significantly lower than that in healthy controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95% confidence interval [CI]: 0.54-0.93, P = .012), while the heterozygous AC genotype showed a significant protective effect on EC in codominant, dominant, and overdominant models (adjusted OR 0.64, 95% CI: 0.45-0.91, P = .039; OR 0.65, 95% CI: 0.47-0.91, P = .011; OR 0.67, 95% CI: 0.47-0.94, P = .02, respectively), and AA genotype was more frequent in patients with cervical invasion (recessive model: OR 3.55, 95% CI: 1.10-11.44, P = .046). Moreover, ATT/ATT genotype (rs5902434) was conferred a lower risk of EC in the recessive model (adjusted OR 0.58, 95% CI: 0.35-0.96, P = .031). From the data generated, we conclude that Foxp3 promoter polymorphisms are associated with susceptibility to EC in Chinese Han women.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title medicine
Publication Year Start




PMID- 29718856
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20180508
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 18
DP  - 2018 May
TI  - Association of Foxp3 promoter polymorphisms with susceptibility to endometrial
      cancer in the Chinese Han women.
PG  - e0582
LID - 10.1097/MD.0000000000010582 [doi]
AB  - To evaluate the association between Foxp3 gene polymorphisms (rs3761548 and
      rs5902434) and susceptibility to endometrial cancer (EC), we report a hospital
      case-control study involving 602 women, consisting of 269 patients with EC and
      333 healthy controls. Genotyping was performed by polymerase chain
      reaction-restriction fragment length polymorphism. Our results suggest that the
      frequency of the A allele in rs3761548 in patients with EC was significantly
      lower than that in healthy controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95%
      confidence interval [CI]: 0.54-0.93, P = .012), while the heterozygous AC
      genotype showed a significant protective effect on EC in codominant, dominant,
      and overdominant models (adjusted OR 0.64, 95% CI: 0.45-0.91, P = .039; OR 0.65, 
      95% CI: 0.47-0.91, P = .011; OR 0.67, 95% CI: 0.47-0.94, P = .02, respectively), 
      and AA genotype was more frequent in patients with cervical invasion (recessive
      model: OR 3.55, 95% CI: 1.10-11.44, P = .046). Moreover, ATT/ATT genotype
      (rs5902434) was conferred a lower risk of EC in the recessive model (adjusted OR 
      0.58, 95% CI: 0.35-0.96, P = .031). From the data generated, we conclude that
      Foxp3 promoter polymorphisms are associated with susceptibility to EC in Chinese 
      Han women.
FAU - You, Di
AU  - You D
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital,
      Sichuan University.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
FAU - Wang, Yanyun
AU  - Wang Y
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
AD  - Laboratory of Molecular Translational Medicine, West China Institute of Women and
      Children's Health.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
AD  - Department of Pathology, West China Second University Hospital.
FAU - Li, Qin
AU  - Li Q
AD  - Department of Immunology, West China School of Preclinical and Forensic Medicine,
      Sichuan University, Chengdu, Sichuan, China.
FAU - Yu, Xiuzhang
AU  - Yu X
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital,
      Sichuan University.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
FAU - Yuan, Mingwei
AU  - Yuan M
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital,
      Sichuan University.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
FAU - Lan, Zhu
AU  - Lan Z
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital,
      Sichuan University.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
FAU - Zeng, Xi
AU  - Zeng X
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital,
      Sichuan University.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
FAU - Zhou, Bin
AU  - Zhou B
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
AD  - Laboratory of Molecular Translational Medicine, West China Institute of Women and
      Children's Health.
FAU - Song, Yaping
AU  - Song Y
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
AD  - Laboratory of Molecular Translational Medicine, West China Institute of Women and
      Children's Health.
FAU - Su, Min
AU  - Su M
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
AD  - Laboratory of Molecular Translational Medicine, West China Institute of Women and
      Children's Health.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
AD  - Laboratory of Molecular Translational Medicine, West China Institute of Women and
      Children's Health.
AD  - Department of Immunology, West China School of Preclinical and Forensic Medicine,
      Sichuan University, Chengdu, Sichuan, China.
FAU - Xi, Mingrong
AU  - Xi M
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital,
      Sichuan University.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children
      (Sichuan University), Ministry of Education.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
SB  - AIM
SB  - IM
MH  - Asian Continental Ancestry Group/*genetics
MH  - Case-Control Studies
MH  - Endometrial Neoplasms/*genetics/pathology
MH  - Female
MH  - Forkhead Transcription Factors/*genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Neoplasm Invasiveness
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Uterine Cervical Neoplasms/genetics/pathology
EDAT- 2018/05/03 06:00
MHDA- 2018/05/09 06:00
CRDT- 2018/05/03 06:00
PHST- 2018/05/03 06:00 [entrez]
PHST- 2018/05/03 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
AID - 10.1097/MD.0000000000010582 [doi]
AID - 00005792-201805040-00024 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(18):e0582. doi: 10.1097/MD.0000000000010582.