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Cutaneous ulceration: metastases should be suspected.

Abstract We report the case of a 68-year old patient, with a history of chronic smoking, presenting with cutaneous swelling at the level of the anterior chest wall evolving over a period of 5 months and gradually increasing in size. It was associated with gradually worsening exertional dyspnoea evolving in a context of an alteration of general state and 15kg weight loss. Mucocutaneous examination objectified rounded, well-defined cutaneous swelling measuring 5cm x 5cm, with erythematous border and with ulcerated surface (A). Lymph nodes examination showed two painless, mobile, bilateral axillary adenopathies with a firm consistency, each measuring 2cm. Histological and immuno-histochemical examination of skin biopsy specimen showed adenocarcinoma compatible with a lung origin (B and C). Chest CT scan confirmed the presence of left lingular pulmonary process (D). The therapeutic approach was based on pemetrexed + platinum salt chemotherapy. The patient died 4 months after the diagnosis of the disease.
PMID
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Authors

Mayor MeshTerms
Keywords

Cuteneous ulcers

cutaneous metastases

lung cancer

Journal Title the pan african medical journal
Publication Year Start




PMID- 29721134
OWN - NLM
STAT- MEDLINE
DCOM- 20180510
LR  - 20180510
IS  - 1937-8688 (Electronic)
VI  - 28
DP  - 2017
TI  - [Cutaneous ulceration: metastases should be suspected].
PG  - 304
LID - 10.11604/pamj.2017.28.304.13326 [doi]
AB  - We report the case of a 68-year old patient, with a history of chronic smoking,
      presenting with cutaneous swelling at the level of the anterior chest wall
      evolving over a period of 5 months and gradually increasing in size. It was
      associated with gradually worsening exertional dyspnoea evolving in a context of 
      an alteration of general state and 15kg weight loss. Mucocutaneous examination
      objectified rounded, well-defined cutaneous swelling measuring 5cm x 5cm, with
      erythematous border and with ulcerated surface (A). Lymph nodes examination
      showed two painless, mobile, bilateral axillary adenopathies with a firm
      consistency, each measuring 2cm. Histological and immuno-histochemical
      examination of skin biopsy specimen showed adenocarcinoma compatible with a lung 
      origin (B and C). Chest CT scan confirmed the presence of left lingular pulmonary
      process (D). The therapeutic approach was based on pemetrexed + platinum salt
      chemotherapy. The patient died 4 months after the diagnosis of the disease.
FAU - Zemmez, Youssef
AU  - Zemmez Y
AD  - Service de Dermatologie, CHU Ibn Sina Rabat, Maroc.
FAU - Hassam, Badreddine
AU  - Hassam B
AD  - Service de Dermatologie, CHU Ibn Sina Rabat, Maroc.
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Ulceration cutanee: penser aux metastases.
DEP - 20171211
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Adenocarcinoma/*diagnosis/drug therapy/pathology
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & dosage
MH  - Dyspnea/etiology
MH  - Fatal Outcome
MH  - Humans
MH  - Lung Neoplasms/*diagnosis/drug therapy/pathology
MH  - Male
MH  - Skin Neoplasms/*diagnosis/drug therapy/secondary
MH  - Skin Ulcer/*diagnosis/pathology
MH  - Smoking/epidemiology
MH  - Tomography, X-Ray Computed
PMC - PMC5927568
OTO - NOTNLM
OT  - Cuteneous ulcers
OT  - cutaneous metastases
OT  - lung cancer
EDAT- 2018/05/04 06:00
MHDA- 2018/05/11 06:00
CRDT- 2018/05/04 06:00
PHST- 2017/07/11 00:00 [received]
PHST- 2017/11/14 00:00 [accepted]
PHST- 2018/05/04 06:00 [entrez]
PHST- 2018/05/04 06:00 [pubmed]
PHST- 2018/05/11 06:00 [medline]
AID - 10.11604/pamj.2017.28.304.13326 [doi]
AID - PAMJ-28-304 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 Dec 11;28:304. doi: 10.11604/pamj.2017.28.304.13326.
      eCollection 2017.