PubTransformer

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PMID- 29737973
OWN - NLM
STAT- MEDLINE
DCOM- 20180516
LR  - 20180516
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Linking)
VI  - 37
IP  - 6
DP  - 2018 Jun
TI  - In Vivo Endothelial Cell Density Decline in the Early Postoperative Phase After
      Descemet Membrane Endothelial Keratoplasty.
PG  - 673-677
LID - 10.1097/ICO.0000000000001484 [doi]
AB  - PURPOSE: To evaluate endothelial cell density (ECD) in the first 6 months after
      Descemet membrane endothelial keratoplasty (DMEK) by eliminating method error as 
      a confounding variable. METHODS: From 24 DMEK eyes operated for Fuchs endothelial
      corneal dystrophy, from which specular microscopy images could be taken at 1 day 
      and 6 months postoperatively, ECD values were compared between these 2 time
      points. RESULTS: Using the 1-day ECD measurement as baseline, mean ECD decreased 
      from 1913 (+/-326) cells/mm to 1524 (+/-393) cells/mm at 6 months, a decline of
      -18 (+/-19)%. With the 1-week ECD as baseline [1658 (+/-395) cells/mm], the
      decline at 6 months was -6 (+/-19)% and when using preoperative ECD as baseline
      [2521 (+/-122) cells/mm], the decline was -39 (+/-16)% at 6 months. CONCLUSIONS: 
      After DMEK, ECD shows an in vivo decline of 18% from 1 day to 6 months
      postoperatively, with a sharp 13% drop in the first week, and a slower decrease
      thereafter. The remaining difference of 20% from preoperative ECD values may be
      attributed to a measurement error in the eye bank with an overestimation of the
      graft's viable endothelial cell population and/or intraoperative trauma to the
      graft.
FAU - Miron, Alina
AU  - Miron A
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
AD  - Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.
AD  - Amnitrans EyeBank Rotterdam, Rotterdam, The Netherlands.
FAU - Bruinsma, Marieke
AU  - Bruinsma M
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
AD  - Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.
FAU - Ham, Lisanne
AU  - Ham L
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
AD  - Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.
AD  - Amnitrans EyeBank Rotterdam, Rotterdam, The Netherlands.
FAU - Schaal, Sontje-Chiao
AU  - Schaal SC
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
FAU - Baydoun, Lamis
AU  - Baydoun L
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
AD  - Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.
FAU - Dapena, Isabel
AU  - Dapena I
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
AD  - Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.
FAU - Oellerich, Silke
AU  - Oellerich S
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
FAU - Melles, Gerrit R J
AU  - Melles GRJ
AD  - Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
AD  - Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.
AD  - Amnitrans EyeBank Rotterdam, Rotterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Corneal Endothelial Cell Loss/*pathology
MH  - Descemet Membrane/*surgery
MH  - Descemet Stripping Endothelial Keratoplasty/*adverse effects/methods
MH  - Female
MH  - Fuchs' Endothelial Dystrophy/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/pathology
EDAT- 2018/05/09 06:00
MHDA- 2018/05/17 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/09 06:00 [pubmed]
PHST- 2018/05/17 06:00 [medline]
AID - 10.1097/ICO.0000000000001484 [doi]
AID - 00003226-201806000-00001 [pii]
PST - ppublish
SO  - Cornea. 2018 Jun;37(6):673-677. doi: 10.1097/ICO.0000000000001484.