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PMID- 29739379
OWN - NLM
STAT- MEDLINE
DCOM- 20180516
LR  - 20180516
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 18
IP  - 1
DP  - 2018 May 8
TI  - Assessment of capillary dropout in the superficial retinal capillary plexus by
      optical coherence tomography angiography in the early stage of diabetic
      retinopathy.
PG  - 113
LID - 10.1186/s12886-018-0778-2 [doi]
AB  - BACKGROUND: To assess capillary dropout in the superficial retinal capillary
      plexus (SCP) by optical coherence tomography angiography (OCTA) in the early
      stage of diabetic retinopathy (DR). METHODS: This study was a cross-sectional
      observational study. Patients that underwent OCTA examinations in our hospital
      between November 2015 and May 2016 were included in the study. The subjects were 
      divided into two groups: A) normal controls (41 eyes of 41 subjects) and B) the
      DR patients (49 eyes of 49 patients with mild non-proliferative DR (NPDR)). The
      retinal thickness and SCP vessel density were analyzed using built-in software in
      nine sections of the macular area; whole scan area; fovea; parafovea; and
      sub-sections of the parafovea, superior-hemi, inferior-hemi, temporal, superior, 
      nasal, and inferior. The correlation between vessel density and retinal thickness
      was also analyzed. RESULTS: The SCP density was significantly lower (P < 0.05) in
      mild NPDR patients than in normal controls in all areas, with the exception of
      the fovea (P > 0.05). In the parafovea, superior-hemi, inferior-hemi, temporal,
      and nasal sectors of group B, the SCP density was negatively correlated with the 
      corresponding retinal thickness (P < 0.05). Specifically, as the SCP density
      decreased, retinal thickness increased. CONCLUSIONS: In the early stage of NPDR, 
      retinal capillary dropout and retinal thickness changes can be clearly captured
      and analyzed by OCTA. The results confirm a negative correlation between vessel
      density and retinal thickness in diabetic patients. This noninvasive technique
      could be applied for DR detection and monitoring. Further study with a larger
      sample size is warranted.
FAU - Shen, Ceying
AU  - Shen C
AUID- ORCID: http://orcid.org/0000-0001-9496-0309
AD  - Department of Zhengzhou Second People Hospital, Ophthalmology, Zhengzhou Eye
      Hospital, Zhengzhou Ophthalmic Institution, Zhengzhou Hanghai Middle Road No. 90,
      Zhengzhou, 450000, China. [email protected]
FAU - Yan, Shu
AU  - Yan S
AD  - Department of Zhengzhou Second People Hospital, Ophthalmology, Zhengzhou Eye
      Hospital, Zhengzhou Ophthalmic Institution, Zhengzhou Hanghai Middle Road No. 90,
      Zhengzhou, 450000, China.
FAU - Du, Min
AU  - Du M
AD  - Department of Zhengzhou Second People Hospital, Ophthalmology, Zhengzhou Eye
      Hospital, Zhengzhou Ophthalmic Institution, Zhengzhou Hanghai Middle Road No. 90,
      Zhengzhou, 450000, China.
FAU - Zhao, Hong
AU  - Zhao H
AD  - Department of Zhengzhou Second People Hospital, Ophthalmology, Zhengzhou Eye
      Hospital, Zhengzhou Ophthalmic Institution, Zhengzhou Hanghai Middle Road No. 90,
      Zhengzhou, 450000, China.
FAU - Shao, Ling
AU  - Shao L
AD  - Department of Zhengzhou Second People Hospital, Ophthalmology, Zhengzhou Eye
      Hospital, Zhengzhou Ophthalmic Institution, Zhengzhou Hanghai Middle Road No. 90,
      Zhengzhou, 450000, China.
FAU - Hu, Yibo
AU  - Hu Y
AD  - Department of Zhengzhou Second People Hospital, Ophthalmology, Zhengzhou Eye
      Hospital, Zhengzhou Ophthalmic Institution, Zhengzhou Hanghai Middle Road No. 90,
      Zhengzhou, 450000, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180508
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Adult
MH  - Aged
MH  - Capillaries/*pathology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetic Retinopathy/*pathology
MH  - Eye/blood supply
MH  - Female
MH  - Fluorescein Angiography/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence/methods
PMC - PMC5941753
OTO - NOTNLM
OT  - Capillary dropout
OT  - Diabetes mellitus
OT  - Diabetic retinopathy
OT  - Optical coherence tomography angiography
OT  - Retinal capillary
EDAT- 2018/05/10 06:00
MHDA- 2018/05/17 06:00
CRDT- 2018/05/10 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2018/04/27 00:00 [accepted]
PHST- 2018/05/10 06:00 [entrez]
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/17 06:00 [medline]
AID - 10.1186/s12886-018-0778-2 [doi]
AID - 10.1186/s12886-018-0778-2 [pii]
PST - epublish
SO  - BMC Ophthalmol. 2018 May 8;18(1):113. doi: 10.1186/s12886-018-0778-2.