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The plasma levels of 12 cytokines and growth factors in patients with gastric cancer.

Abstract To assess the association of plasma cytokines and growth factor levels with clinical characteristics and inflammatory indices in patients with gastric cancer.Plasma samples derived from 99 gastric cancer patients were used for analysis. Levels of interferon (IFN)-γ, tumor growth factor (TGF)-β1, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-12p70, and vascular endothelial growth factor (VEGF) were measured by Luminex suspension array technology. The association between cytokine/growth factor levels and demographic/clinical characteristics was assessed. Correlation between cytokines and growth factor levels was assessed by Pearson's correlation analysis.Male patients had significant higher levels of plasma TNF-α, IL-12p70, IL-4, IL-10, and VEGF as compared with those in women (P < .05). Plasma levels of TNF-α in older patients with gastric cancer (≥60 years) were higher than those in young patients (P < .05). Elevated plasma levels of IL-8 and IL-10 were identified as risk factors for increased tumor size (diameter ≥5 cm). Higher plasma levels of TGF-β1 were associated with increased risk of vascular or nerve invasion and advanced tumor stage. The levels of systemic inflammatory markers, including white blood cell counts, neutrophil/lymphocyte proportion, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), C-reactive protein and modified Glasgow prognostic score (mGPS) were closely associated with a series of plasma cytokines. A prominent correlation was observed between the plasma IL-12p70 and IFN-γ levels (r = 0.729, P < .01).Our findings suggest that plasma cytokines and growth factor levels may help predict the development and progression of gastric cancer. Our findings need to be validated by larger studies.
PMID
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Authors

Mayor MeshTerms

Interleukins

Stomach Neoplasms

Tumor Necrosis Factors

Keywords
Journal Title medicine
Publication Year Start




PMID- 29742685
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20180515
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 19
DP  - 2018 May
TI  - The plasma levels of 12 cytokines and growth factors in patients with gastric
      cancer.
PG  - e0413
LID - 10.1097/MD.0000000000010413 [doi]
AB  - To assess the association of plasma cytokines and growth factor levels with
      clinical characteristics and inflammatory indices in patients with gastric
      cancer.Plasma samples derived from 99 gastric cancer patients were used for
      analysis. Levels of interferon (IFN)-gamma, tumor growth factor (TGF)-beta1,
      tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-2, IL-4,
      IL-6, IL-8, IL-10, IL-12p40, IL-12p70, and vascular endothelial growth factor
      (VEGF) were measured by Luminex suspension array technology. The association
      between cytokine/growth factor levels and demographic/clinical characteristics
      was assessed. Correlation between cytokines and growth factor levels was assessed
      by Pearson's correlation analysis.Male patients had significant higher levels of 
      plasma TNF-alpha, IL-12p70, IL-4, IL-10, and VEGF as compared with those in women
      (P &lt; .05). Plasma levels of TNF-alpha in older patients with gastric cancer
      (&gt;/=60 years) were higher than those in young patients (P &lt; .05). Elevated plasma
      levels of IL-8 and IL-10 were identified as risk factors for increased tumor size
      (diameter &gt;/=5 cm). Higher plasma levels of TGF-beta1 were associated with
      increased risk of vascular or nerve invasion and advanced tumor stage. The levels
      of systemic inflammatory markers, including white blood cell counts,
      neutrophil/lymphocyte proportion, neutrophil-to-lymphocyte ratio,
      platelet-to-lymphocyte ratio (PLR), C-reactive protein and modified Glasgow
      prognostic score (mGPS) were closely associated with a series of plasma
      cytokines. A prominent correlation was observed between the plasma IL-12p70 and
      IFN-gamma levels (r = 0.729, P &lt; .01).Our findings suggest that plasma cytokines 
      and growth factor levels may help predict the development and progression of
      gastric cancer. Our findings need to be validated by larger studies.
FAU - Zou, Zhengyun
AU  - Zou Z
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Zhao, Lianjun
AU  - Zhao L
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Su, Shu
AU  - Su S
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Liu, Qin
AU  - Liu Q
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Yu, Lixia
AU  - Yu L
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Wei, Jia
AU  - Wei J
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Yang, Yang
AU  - Yang Y
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Du, Juan
AU  - Du J
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Shen, Jie
AU  - Shen J
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Qian, Xiaoping
AU  - Qian X
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
FAU - Fan, Xiangshan
AU  - Fan X
AD  - The Pathology Department of Drum-Tower Hospital Affiliated to Medical School of
      Nanjing University.
FAU - Guan, Wenxian
AU  - Guan W
AD  - The General Surgery Department of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Nanjing, China.
FAU - Liu, Baorui
AU  - Liu B
AD  - The Comprehensive Cancer Center of Drum-Tower Hospital Affiliated to Medical
      School of Nanjing University, Clinical Cancer Institute of Nanjing University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Interleukins)
RN  - 0 (Tumor Necrosis Factors)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - AIM
SB  - IM
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Inflammation/blood
MH  - *Interleukins/blood/classification
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reproducibility of Results
MH  - *Stomach Neoplasms/blood/epidemiology/pathology
MH  - *Tumor Necrosis Factors/blood/classification
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2018/05/10 06:00
MHDA- 2018/05/16 06:00
CRDT- 2018/05/10 06:00
PHST- 2018/05/10 06:00 [entrez]
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
AID - 10.1097/MD.0000000000010413 [doi]
AID - 00005792-201805110-00004 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(19):e0413. doi: 10.1097/MD.0000000000010413.