Anterior mediastinal Hodgkin lymphoma presenting as an extremely hypervascular tumor on computed tomography: A case report.
|Abstract||In the thorax, Hodgkin lymphoma (HL) most frequently involves the anterior mediastinal and paratracheal regions and tends to spread to contiguous nodal groups. Enlarged lymph nodes typically have homogeneous soft tissue attenuation similar to that of muscle tissue on computed tomography (CT).|
Randomized Phase III Trial Comparing ABVD Plus Radiotherapy With the Stanford V Regimen in Patients With Stages I or II Locally Extensive, Bulky Mediastinal Hodgkin Lymphoma: A Subset Analysis of the North American Intergroup E2496 Trial.
|Publication Year Start||2018-01-01|
PMID- 29742695 OWN - NLM STAT- MEDLINE DCOM- 20180515 LR - 20180515 IS - 1536-5964 (Electronic) IS - 0025-7974 (Linking) VI - 97 IP - 19 DP - 2018 May TI - Anterior mediastinal Hodgkin lymphoma presenting as an extremely hypervascular tumor on computed tomography: A case report. PG - e0607 LID - 10.1097/MD.0000000000010607 [doi] AB - RATIONALE: In the thorax, Hodgkin lymphoma (HL) most frequently involves the anterior mediastinal and paratracheal regions and tends to spread to contiguous nodal groups. Enlarged lymph nodes typically have homogeneous soft tissue attenuation similar to that of muscle tissue on computed tomography (CT). PATIENT CONCERNS: A contrast-enhanced CT examination of a 19-year-old man with right-sided chest pain showed an intense, heterogeneously enhancing mass with organization of serpentine and dilated blood vessels in the right anterior mediastinum that had invaded the upper lobe of the right lung. DIAGNOSES: Following a wedge resection, histopathological examination showed Reed-Sternberg cells that were positive for CD-15 and CD-30, which is typical of HL. INTERVENTIONS: The patient was started treatment with 6 cycles of doxorubicin, bleomycin, vincristine, and dacarbazine (ABVD) regimen. OUTCOMES: After chemotherapy, the patient had shown a partial response to the treatment. LESSONS: This presentation of HL as an extremely hypervascular anterior mediastinal mass on CT imaging has not been previously reported in the literature. This case suggests that HL should be included in the differential diagnosis of a hypervascular anterior mediastinal mass, especially if the patient is a young adult. FAU - Lee, Soo Jeong AU - Lee SJ AD - Department of Radiology. FAU - Rho, Ji Young AU - Rho JY AD - Department of Radiology. FAU - Kim, Gwang Il AU - Kim GI AD - Department of Pathology. FAU - Park, Joonsuk AU - Park J AD - Department of Thoracic Surgery, CHA Bundang Medical Center, CHA University, Bundang-gu, Seongnam-si, Republic of Korea. LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Antineoplastic Agents) RN - 11056-06-7 (Bleomycin) RN - 5V9KLZ54CY (Vinblastine) RN - 7GR28W0FJI (Dacarbazine) RN - 80168379AG (Doxorubicin) RN - ABVD protocol SB - AIM SB - IM MH - Antineoplastic Agents/*administration & dosage MH - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage MH - Bleomycin/administration & dosage MH - Dacarbazine/administration & dosage MH - Diagnosis, Differential MH - Dissection/*methods MH - Doxorubicin/administration & dosage MH - *Hodgkin Disease/diagnosis/pathology/physiopathology/therapy MH - Humans MH - Lung/diagnostic imaging MH - Male MH - *Mediastinal Neoplasms/diagnosis/pathology/physiopathology/therapy MH - *Mediastinum/blood supply/diagnostic imaging MH - Reed-Sternberg Cells/pathology MH - Regional Blood Flow MH - Tomography, X-Ray Computed/methods MH - Vinblastine/administration & dosage MH - Young Adult EDAT- 2018/05/10 06:00 MHDA- 2018/05/16 06:00 CRDT- 2018/05/10 06:00 PHST- 2018/05/10 06:00 [entrez] PHST- 2018/05/10 06:00 [pubmed] PHST- 2018/05/16 06:00 [medline] AID - 10.1097/MD.0000000000010607 [doi] AID - 00005792-201805110-00014 [pii] PST - ppublish SO - Medicine (Baltimore). 2018 May;97(19):e0607. doi: 10.1097/MD.0000000000010607.