PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Effect of photobiomodulation treatment in the sublingual, radial artery region, and along the spinal column in individuals with multiple sclerosis: Protocol for a randomized, controlled, double-blind, clinical trial.

Abstract Multiple sclerosis (MS) is an autoimmune disease, for which the forms of treatment are medication and rehabilitation. However, in vitro and in vivo studies have demonstrated that photobiomodulation can be an effective treatment modality for inflammatory diseases, including MS. Photobiomodulation has a broad range of benefits, such as the avoidance of cell and tissue death, the stimulation of healing and injury repair, reductions in pain, edema and inflammation, cell proliferation, and even apoptosis. The outcomes of photobiomodulation include the regeneration of cells, the stimulation of the growth of Schwann cells, a reduction in spasticity, functional improvements, a reduction in nitric oxide levels, and the upregulation of the cytokine IL10, demonstrating that this therapeutic modality can offer neuroprotection.
PMID
Related Publications

Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety.

Photobiomodulation induced by 670 nm light ameliorates MOG35-55 induced EAE in female C57BL/6 mice: a role for remediation of nitrosative stress.

Red LED photobiomodulation reduces pain hypersensitivity and improves sensorimotor function following mild T10 hemicontusion spinal cord injury.

Cannabis-based medicines--GW pharmaceuticals: high CBD, high THC, medicinal cannabis--GW pharmaceuticals, THC:CBD.

Characterization of Macrophage/Microglial Activation and Effect of Photobiomodulation in the Spared Nerve Injury Model of Neuropathic Pain.

Authors

Mayor MeshTerms

Multiple Sclerosis

Keywords
Journal Title medicine
Publication Year Start




PMID- 29742699
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20180515
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 19
DP  - 2018 May
TI  - Effect of photobiomodulation treatment in the sublingual, radial artery region,
      and along the spinal column in individuals with multiple sclerosis: Protocol for 
      a randomized, controlled, double-blind, clinical trial.
PG  - e0627
LID - 10.1097/MD.0000000000010627 [doi]
AB  - BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease, for which the forms
      of treatment are medication and rehabilitation. However, in vitro and in vivo
      studies have demonstrated that photobiomodulation can be an effective treatment
      modality for inflammatory diseases, including MS. Photobiomodulation has a broad 
      range of benefits, such as the avoidance of cell and tissue death, the
      stimulation of healing and injury repair, reductions in pain, edema and
      inflammation, cell proliferation, and even apoptosis. The outcomes of
      photobiomodulation include the regeneration of cells, the stimulation of the
      growth of Schwann cells, a reduction in spasticity, functional improvements, a
      reduction in nitric oxide levels, and the upregulation of the cytokine IL10,
      demonstrating that this therapeutic modality can offer neuroprotection. METHODS: 
      A randomized, controlled, double-blind, clinical trial is proposed. The patients 
      will be divided into 6 groups. Groups 1 and 2 will receive sham and active
      photobiomodulation in the sublingual region, respectively. Groups 3 and 4 will
      receive sham and active photobiomodulation along the spinal cord, respectively.
      Group 5 will receive placebo treatment with photobiomodulation on the skin in the
      region of the radial artery with a specific bracelet. Group 6 will be treated
      with photobiomodulation on the skin in the region of the radial artery.
      DISCUSSION: Treatment for MS is directed at the immune response and slowing the
      progression of the disease. This is one of the first clinical trials involving
      photobiomodulation in the sublingual region and along the spinal cord, which
      could help establish a promising new form of nonpharmacological treatment for
      autoimmune diseases. This is one of the first clinical trials with sublingual
      photobiomodulation and along the spinal cord that could help establish a new form
      of promising treatment of the disease associated with pharmacological treatment.
FAU - da Silva, Tamiris
AU  - da Silva T
AD  - Nove de Julho University (UNINOVE).
FAU - da Silva, Fernanda Cordeiro
AU  - da Silva FC
AD  - Nove de Julho University (UNINOVE).
FAU - Gomes, Andrea Oliver
AU  - Gomes AO
AD  - Nove de Julho University (UNINOVE).
FAU - Viana, Ariane Oliveira
AU  - Viana AO
AD  - Nove de Julho University (UNINOVE).
FAU - Goncalves, Marcela Leticia Leal
AU  - Goncalves MLL
AD  - Nove de Julho University (UNINOVE).
FAU - Rodrigues, Maria Fernanda Setubal Destro
AU  - Rodrigues MFSD
AD  - Nove de Julho University (UNINOVE).
FAU - Horliana, Anna Carolina Ratto Tempestini
AU  - Horliana ACRT
AD  - Nove de Julho University (UNINOVE).
FAU - da Silva, Daniela de Fatima Teixeira
AU  - da Silva DFT
AD  - Nove de Julho University (UNINOVE).
FAU - Chavantes, Maria Cristina
AU  - Chavantes MC
AD  - Nove de Julho University (UNINOVE).
FAU - Fragoso, Yara Dadalti
AU  - Fragoso YD
AD  - University Metropolitana de Santos (UNIMES) University, Santos, Brazil.
FAU - Branco, Luciana Prats
AU  - Branco LP
AD  - University Metropolitana de Santos (UNIMES) University, Santos, Brazil.
FAU - Motta, Lara Jansiski
AU  - Motta LJ
AD  - Nove de Julho University (UNINOVE).
FAU - Fernandes, Kristianne Porta Santos
AU  - Fernandes KPS
AD  - Nove de Julho University (UNINOVE).
FAU - Mesquita-Ferrari, Raquel Agnelli
AU  - Mesquita-Ferrari RA
AD  - Nove de Julho University (UNINOVE).
FAU - Bussadori, Sandra Kalil
AU  - Bussadori SK
AD  - Nove de Julho University (UNINOVE).
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Double-Blind Method
MH  - Humans
MH  - Inflammation/immunology
MH  - Low-Level Light Therapy/*methods
MH  - Monitoring, Physiologic/methods
MH  - Mouth Floor/radiation effects
MH  - *Multiple Sclerosis/immunology/therapy
MH  - Oxidative Stress/radiation effects
MH  - Research Design
MH  - Spinal Cord/radiation effects
EDAT- 2018/05/10 06:00
MHDA- 2018/05/16 06:00
CRDT- 2018/05/10 06:00
PHST- 2018/05/10 06:00 [entrez]
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
AID - 10.1097/MD.0000000000010627 [doi]
AID - 00005792-201805110-00018 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(19):e0627. doi: 10.1097/MD.0000000000010627.