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Preoperative magnetic resonance imaging characteristics of oval circumscribed fast enhancing lesions in patients with newly diagnosed breast cancer.

Abstract The aim of this study was to investigate the follow-up results and characteristics of oval circumscribed lesions with fast initial enhancement on preoperative magnetic resonance imaging (MRI) in patients with newly diagnosed breast cancer.Preoperative data from consecutive patients newly diagnosed with breast cancer between 2010 and 2013 were retrospectively reviewed. Only MRI reports containing, "oval shape, circumscribed margin, and fast initial enhancement," were extracted and analyzed. Follow-up results and clinical and pathological findings were evaluated.A total of 430 oval circumscribed lesions with fast initial enhancement were included. Forty-eight lesions were pathologically confirmed at initial workup and 382 were followed up. Among the 48 lesions, 14 were found to have additional malignancy and 34 were benign. Among the 382 followed-up lesions, only 1 was subsequently confirmed to be malignant. There were no evident changes in any of the remaining lesions during follow-up. The overall rate of malignancy was 3.5% (15/430). When lesions exhibited delayed washout enhancing kinetics (P < .001), were located ipsilaterally (P = .007), and closer to the primary tumor (P = .012), the possibility of malignancy was high. High T2-weighted imaging signal intensity suggested benignity (P = .043).Although the probability of being diagnosed with malignancy during follow-up in this study was low (0.3%), this investigation revealed several preoperative MRI characteristics that should alert clinicians to the possibility of malignancy.
PMID
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Authors

Mayor MeshTerms

Magnetic Resonance Imaging

Preoperative Period

Keywords
Journal Title medicine
Publication Year Start




PMID- 29742727
OWN - NLM
STAT- MEDLINE
DCOM- 20180516
LR  - 20180516
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 19
DP  - 2018 May
TI  - Preoperative magnetic resonance imaging characteristics of oval circumscribed
      fast enhancing lesions in patients with newly diagnosed breast cancer.
PG  - e0704
LID - 10.1097/MD.0000000000010704 [doi]
AB  - The aim of this study was to investigate the follow-up results and
      characteristics of oval circumscribed lesions with fast initial enhancement on
      preoperative magnetic resonance imaging (MRI) in patients with newly diagnosed
      breast cancer.Preoperative data from consecutive patients newly diagnosed with
      breast cancer between 2010 and 2013 were retrospectively reviewed. Only MRI
      reports containing, "oval shape, circumscribed margin, and fast initial
      enhancement," were extracted and analyzed. Follow-up results and clinical and
      pathological findings were evaluated.A total of 430 oval circumscribed lesions
      with fast initial enhancement were included. Forty-eight lesions were
      pathologically confirmed at initial workup and 382 were followed up. Among the 48
      lesions, 14 were found to have additional malignancy and 34 were benign. Among
      the 382 followed-up lesions, only 1 was subsequently confirmed to be malignant.
      There were no evident changes in any of the remaining lesions during follow-up.
      The overall rate of malignancy was 3.5% (15/430). When lesions exhibited delayed 
      washout enhancing kinetics (P &lt; .001), were located ipsilaterally (P = .007), and
      closer to the primary tumor (P = .012), the possibility of malignancy was high.
      High T2-weighted imaging signal intensity suggested benignity (P = .043).Although
      the probability of being diagnosed with malignancy during follow-up in this study
      was low (0.3%), this investigation revealed several preoperative MRI
      characteristics that should alert clinicians to the possibility of malignancy.
FAU - Lee, Jong Yoon
AU  - Lee JY
AD  - Department of Radiology, Borame Medical Center 20, Boramae-ro 5-gil, Dongjak-gu, 
      Seoul 07061, South Korea.
FAU - Jang, Mijung
AU  - Jang M
AD  - Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si,
      Gyeonggi-do.
FAU - Kim, Sun Mi
AU  - Kim SM
AD  - Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si,
      Gyeonggi-do.
FAU - Yun, Bo La
AU  - Yun B
AD  - Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si,
      Gyeonggi-do.
FAU - Jang, Ja Yoon
AU  - Jang JY
AD  - Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si,
      Gyeonggi-do.
FAU - Ahn, Hye Shin
AU  - Ahn HS
AD  - Department of Radiology, Chung-Ang University Hospital, Dongjak-gu, South Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Breast Neoplasms/*diagnostic imaging/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Middle Aged
MH  - *Preoperative Period
MH  - Retrospective Studies
EDAT- 2018/05/10 06:00
MHDA- 2018/05/17 06:00
CRDT- 2018/05/10 06:00
PHST- 2018/05/10 06:00 [entrez]
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/17 06:00 [medline]
AID - 10.1097/MD.0000000000010704 [doi]
AID - 00005792-201805110-00046 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(19):e0704. doi: 10.1097/MD.0000000000010704.