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Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma.

Abstract A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role of serum LDH in osteosarcoma patients.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29742740
OWN - NLM
STAT- MEDLINE
DCOM- 20180516
LR  - 20180516
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 19
DP  - 2018 May
TI  - Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma.
PG  - e0741
LID - 10.1097/MD.0000000000010741 [doi]
AB  - BACKGROUNDS: A large number of studies have reported the relationships between
      serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the
      result is still controversial and no consensus has been reached. Therefore, we
      performed a meta-analysis to evaluate the prognostic role of serum LDH in
      osteosarcoma patients. METHODS: We performed the systematic computerized search
      for eligible articles from PubMed, Embase, and Cochrane databases until December 
      21, 2017. The pooled hazard ratio (HR) and 95% confidence intervals (CIs) of
      overall survival (OS) and event-free survival (EFS) were obtained to assess the
      prognostic value of serum LDH. RESULTS: A total of 18 studies with 2543
      osteosarcoma patients were included. Overall, 15 studies assessed the elevated
      serum LDH level on OS and the pooled HR was 1.87 (95% CI = 1.58-2.20). Meanwhile,
      the pooled HR to evaluate the relationship between serum LDH and EFS in 9 studies
      was 1.78 (95% CI = 1.51-2.10). The same results were acquired when these studies 
      were stratified by Enneking stage, geographic region, and sample size. No
      heterogeneity existed between these subgroups (P > .05). Begg's funnel plot and
      Egger's test (OS: P = .04; EFS: P = .34) showed that possible publication bias
      might exist in OS studies. Sensitivity analysis suggested the pooled HR was
      robust. CONCLUSIONS: This meta-analysis demonstrates that elevated serum LDH
      level is apparently associated with lower EFS rate and serum LDH could be a
      prognostic biomarker for osteosarcoma patients.
FAU - Fu, Yucheng
AU  - Fu Y
AD  - Department of Surgical Intensive Care Unit (SICU), The First Affiliated Hospital,
      School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province.
FAU - Lan, Tao
AU  - Lan T
AD  - Department of Spine Surgery, Shenzhen Second People's Hospital, The First
      Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province.
FAU - Cai, Hongliu
AU  - Cai H
AD  - Department of Surgical Intensive Care Unit (SICU), The First Affiliated Hospital,
      School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province.
FAU - Lu, Anwei
AU  - Lu A
AD  - Department of Surgical Intensive Care Unit (SICU), The First Affiliated Hospital,
      School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province.
FAU - Yu, Wei
AU  - Yu W
AD  - Department of Orthopedics, Second Affiliated Hospital, School of Medicine,
      Zhejiang University, Hangzhou, Zhejiang Province, PR China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers, Tumor)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - AIM
SB  - IM
MH  - Biomarkers, Tumor/*blood
MH  - Bone Neoplasms/*enzymology/*mortality
MH  - Disease-Free Survival
MH  - Humans
MH  - L-Lactate Dehydrogenase/*blood
MH  - Osteosarcoma/*enzymology/*mortality
EDAT- 2018/05/10 06:00
MHDA- 2018/05/17 06:00
CRDT- 2018/05/10 06:00
PHST- 2018/05/10 06:00 [entrez]
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/17 06:00 [medline]
AID - 10.1097/MD.0000000000010741 [doi]
AID - 00005792-201805110-00059 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(19):e0741. doi: 10.1097/MD.0000000000010741.