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PMID- 29764389
OWN - NLM
STAT- MEDLINE
DCOM- 20180525
LR  - 20180525
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 18
IP  - 1
DP  - 2018 May 15
TI  - Comparison of hyperdry amniotic membrane transplantation and conjunctival
      autografting for primary pterygium.
PG  - 119
LID - 10.1186/s12886-018-0784-4 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate the safety and
      effectiveness of the hyperdry amniotic membrane transplantation compared with
      conjunctival autografting for the treatment of primary pterygium. METHODS: One
      hundred and forty-one eyes from 130 patients with primary pterygium were treated 
      with excision followed by hyperdry amniotic membrane or conjunctival autografting
      after random selection. Seventy-nine eyes from 71 patients received hyperdry
      amniotic membrane transplantation (HD-AM group), and 62 eyes from 59 patients
      received conjunctival autografting (CG group). Patients were followed up at one
      week and one, three, six, and 12 months post-surgery. Recurrence rate,
      postoperative complications, and final follow-up patient visits were
      prospectively evaluated. RESULTS: The mean follow-up duration was 12.56 +/- 4.35 
      months in the HD-AM group and 12.85 +/- 3.90 months in the CG group. Recurrences 
      were detected in four eyes (5.06%) in the HD-AM group and 13 eyes (20.97%) in the
      CG group. A statistically significant difference in frequency of recurrence
      between the two groups (P = 0.003) was observed. The cumulative non-recurrence
      rates at six and 12 months in all patients stratified by age and sex were not
      significantly different (P = 0.642 and P = 0.451, respectively, by log-rank
      test). Graft retraction and necrosis were not detected in the two groups during
      the follow-up period. CONCLUSION: Hyperdry amniotic membrane transplantation was 
      effective in preventing pterygium recurrence when compared with conjunctival
      autografting and can be considered a preferable and safe grafting procedure for
      primary pterygium. TRIAL REGISTRATION: Current Controlled Trials ISRCTN16900270 ,
      Retrospectively registered (Date of registration: 3 May 2018).
FAU - Pan, Xin
AU  - Pan X
AD  - The Second Hospital of Jilin University, No.218, Ziqiang Road, Changchun, 130041,
      China.
FAU - Zhang, Daguang
AU  - Zhang D
AD  - The First Hospital of Jilin University, No.71, Xinmin Road, Changchun, 130021,
      China.
FAU - Jia, Zhifang
AU  - Jia Z
AD  - The First Hospital of Jilin University, No.71, Xinmin Road, Changchun, 130021,
      China.
FAU - Chen, Zhehui
AU  - Chen Z
AD  - The Second Hospital of Jilin University, No.218, Ziqiang Road, Changchun, 130041,
      China.
FAU - Su, Yuetian
AU  - Su Y
AD  - The Second Hospital of Jilin University, No.218, Ziqiang Road, Changchun, 130041,
      China. [email protected]
LA  - eng
GR  - [2016]No.473/the Plan of Jilin Education Department "Thirteen-Five" Science and
      Technology research
PT  - Journal Article
DEP - 20180515
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amnion/*transplantation
MH  - Conjunctiva/*transplantation
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Survival
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ophthalmologic Surgical Procedures/*methods
MH  - Pterygium/*surgery
MH  - Recurrence
MH  - Retrospective Studies
MH  - Transplantation, Autologous
PMC - PMC5952845
OTO - NOTNLM
OT  - Conjunctival autografting
OT  - Hyperdry amniotic membrane transplantation
OT  - Primary pterygium
OT  - Recurrence rate
EDAT- 2018/05/17 06:00
MHDA- 2018/05/26 06:00
CRDT- 2018/05/17 06:00
PHST- 2016/11/01 00:00 [received]
PHST- 2018/05/08 00:00 [accepted]
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/26 06:00 [medline]
AID - 10.1186/s12886-018-0784-4 [doi]
AID - 10.1186/s12886-018-0784-4 [pii]
PST - epublish
SO  - BMC Ophthalmol. 2018 May 15;18(1):119. doi: 10.1186/s12886-018-0784-4.