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Is nucleate cell count and neutrophil to lymphocyte ratio related to patients with audiographically distinct sudden sensorineural hearing loss?

Abstract The aim of this study was to investigate the possible relationships between sudden sensorineural hearing loss (SSNHL) patients with distinct audiographic data and nucleate cell count and neutrophil to lymphocyte ratio (NLR).SSNHL patients differed in audiographic curves were included, 40 with low-frequency SSNHL (LF-SSNHL), 33 with high-frequency SSNHL (HF-SSNHL), 36 with all-frequency SSNHL (AF-SSNHL), 34 with total-deafness SSNHL (TD-SSNHL), and 31 age- and sex-matched healthy controls. Peripheral venous blood samples were collected and nucleate cell such as white blood cell (WBC), neutrophil and lymphocyte, and NLR were measured. Each group was divided into recovery and unrecovery subgroup according to hearing levels after 1-month therapy, and then compared the difference of the count of WBC, neutrophil and lymphocyte, and NLR between the 2 subgroups.The WBC count of the HF-SSNHL, AF-SSNHL, and TD-SSNHL group was significantly higher than that of the control group (P = .024, P = .003, P = .008, respectively), not for LF-SSNHL group (P = .248). WBC count between LF-SSNHL and AF-SSNHL group was significantly different (P = .045). The neutrophil count of the HF-SSNHL, AF-SSNHL, and TD-SSNHL group was significantly higher than that of the control group (P = .002, P = .000, P = .000, respectively), not for LF-SSNHL group (P = .069). Neutrophil count of LF-SSNHL was significantly lower than that of AF-SSNHL and TD-SSNHL groups (P = .014, P = .013). The lymphocyte count of AF-SSNHL and TD-SSNHL group was significantly lower than that of the control group (P = .027, P = .003), not for LF-SSNHL and HF-SSNHL group (P = .119, P = .054). NLR of HF-SSNHL, AF-SSNHL, and TD-SSNHL group was significantly higher than that of the control group (P = .001, P = .000, P = .000, respectively), not for LF-SSNHL group (P = .070). NLR of LF-SSNHL was significantly lower than that of AF-SSNHL and TD-SSNHL group (P = .041, P = .005). In HF-SSNHL patients, lymphocyte count of unrecovery subgroup was significantly lower, while NLR of the unrecovery subgroup were significantly higher than those of recovery subgroup (P = .017, P = .015).The count of WBC, neutrophil, lymphocyte, and NLR may be related to SSNHL, but they were unreliable at predicting SSNHL characterized by differences in audiometric curves. Higher NLR and lower lymphocyte count maybe used to evaluate prognosis of HF-SSNHL patients.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29768325
OWN - NLM
STAT- MEDLINE
DCOM- 20180525
LR  - 20180525
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 20
DP  - 2018 May
TI  - Is nucleate cell count and neutrophil to lymphocyte ratio related to patients
      with audiographically distinct sudden sensorineural hearing loss?
PG  - e10586
LID - 10.1097/MD.0000000000010586 [doi]
AB  - The aim of this study was to investigate the possible relationships between
      sudden sensorineural hearing loss (SSNHL) patients with distinct audiographic
      data and nucleate cell count and neutrophil to lymphocyte ratio (NLR).SSNHL
      patients differed in audiographic curves were included, 40 with low-frequency
      SSNHL (LF-SSNHL), 33 with high-frequency SSNHL (HF-SSNHL), 36 with all-frequency 
      SSNHL (AF-SSNHL), 34 with total-deafness SSNHL (TD-SSNHL), and 31 age- and
      sex-matched healthy controls. Peripheral venous blood samples were collected and 
      nucleate cell such as white blood cell (WBC), neutrophil and lymphocyte, and NLR 
      were measured. Each group was divided into recovery and unrecovery subgroup
      according to hearing levels after 1-month therapy, and then compared the
      difference of the count of WBC, neutrophil and lymphocyte, and NLR between the 2 
      subgroups.The WBC count of the HF-SSNHL, AF-SSNHL, and TD-SSNHL group was
      significantly higher than that of the control group (P = .024, P = .003, P =
      .008, respectively), not for LF-SSNHL group (P = .248). WBC count between
      LF-SSNHL and AF-SSNHL group was significantly different (P = .045). The
      neutrophil count of the HF-SSNHL, AF-SSNHL, and TD-SSNHL group was significantly 
      higher than that of the control group (P = .002, P = .000, P = .000,
      respectively), not for LF-SSNHL group (P = .069). Neutrophil count of LF-SSNHL
      was significantly lower than that of AF-SSNHL and TD-SSNHL groups (P = .014, P = 
      .013). The lymphocyte count of AF-SSNHL and TD-SSNHL group was significantly
      lower than that of the control group (P = .027, P = .003), not for LF-SSNHL and
      HF-SSNHL group (P = .119, P = .054). NLR of HF-SSNHL, AF-SSNHL, and TD-SSNHL
      group was significantly higher than that of the control group (P = .001, P =
      .000, P = .000, respectively), not for LF-SSNHL group (P = .070). NLR of LF-SSNHL
      was significantly lower than that of AF-SSNHL and TD-SSNHL group (P = .041, P =
      .005). In HF-SSNHL patients, lymphocyte count of unrecovery subgroup was
      significantly lower, while NLR of the unrecovery subgroup were significantly
      higher than those of recovery subgroup (P = .017, P = .015).The count of WBC,
      neutrophil, lymphocyte, and NLR may be related to SSNHL, but they were unreliable
      at predicting SSNHL characterized by differences in audiometric curves. Higher
      NLR and lower lymphocyte count maybe used to evaluate prognosis of HF-SSNHL
      patients.
FAU - Sun, Yuanyuan
AU  - Sun Y
AD  - Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth
      People's Hospital, Shanghai, China.
FAU - Xia, Liang
AU  - Xia L
FAU - Wang, Hui
AU  - Wang H
FAU - Chen, Zhengnong
AU  - Chen Z
FAU - Wu, Yaqin
AU  - Wu Y
FAU - Chen, Bin
AU  - Chen B
FAU - Shi, Haibo
AU  - Shi H
FAU - Feng, Yanmei
AU  - Feng Y
FAU - Yin, Shankai
AU  - Yin S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Nerve Growth Factors)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Audiometry
MH  - Dexamethasone/therapeutic use
MH  - Female
MH  - Hearing Loss, Sensorineural/*blood/drug therapy
MH  - Hearing Loss, Sudden/*blood/drug therapy
MH  - Humans
MH  - Leukocyte Count/*methods
MH  - Lymphocyte Count/methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/therapeutic use
MH  - Neutrophils/*cytology
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2018/05/17 06:00
MHDA- 2018/05/26 06:00
CRDT- 2018/05/17 06:00
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/26 06:00 [medline]
AID - 10.1097/MD.0000000000010586 [doi]
AID - 00005792-201805180-00005 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(20):e10586. doi: 10.1097/MD.0000000000010586.