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Usefulness of polydeoxyribonucleotide as an alternative to corticosteroids in patients with lateral epicondyitis: A case series.

Abstract Local corticosteroid injections are commonly used as an easy, cost-effective treatment for patients with lateral epicondylitis (LE). Despite their strong anti-inflammatory effect, repeated injections of corticosteroids are not recommended in LE because they can aggravate tearing of the tendons.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29768379
OWN - NLM
STAT- MEDLINE
DCOM- 20180524
LR  - 20180524
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 20
DP  - 2018 May
TI  - Usefulness of polydeoxyribonucleotide as an alternative to corticosteroids in
      patients with lateral epicondyitis: A case series.
PG  - e10809
LID - 10.1097/MD.0000000000010809 [doi]
AB  - RATIONALE: Local corticosteroid injections are commonly used as an easy,
      cost-effective treatment for patients with lateral epicondylitis (LE). Despite
      their strong anti-inflammatory effect, repeated injections of corticosteroids are
      not recommended in LE because they can aggravate tearing of the tendons. PATIENT 
      CONCERNS: A 65-year-old (Case1) man and a 59-year-old (Case2) man had a 2-month
      history of right lateral elbow pain exacerbation. DIAGNOSES: Lateral
      epicondylitis with hypervascularity of the common extensor tendon. INTERVENTION: 
      After informed consent was provided, ultrasound (US)-guided
      polydeoxyribonucleotide (PDRN) injections were made into on the common extensor
      tendons of both patients. OUTCOMES: After 2 weeks from PDRN injection, both
      patients reported significant pain relief. The US 2 weeks after the PDRN
      injection showed that the hypervascularity of the common extensor tendon in both 
      patients had been completely cured, although there was no significant change in
      the findings of tendinosis. LESSONS: PDRN may be useful for patients with LE
      because there were no negative effects on tendon cells and tissues in previous in
      vitro and in vivo studies, despite its anti-inflammatory effects.
FAU - Lee, Goo Joo
AU  - Lee GJ
AD  - Department of Rehabilitation Medicine, Chungbuk National University Hospital,
      Cheongju, Republic of Korea.
FAU - Park, Donghwi
AU  - Park D
AD  - Department of Rehabilitation Medicine, Daegu Fatima Hospital, Daegu, South Korea.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Polydeoxyribonucleotides)
SB  - AIM
SB  - IM
MH  - Adrenal Cortex Hormones/adverse effects/therapeutic use
MH  - Aged
MH  - Anti-Inflammatory Agents/administration & dosage/*therapeutic use
MH  - Humans
MH  - Injections
MH  - Male
MH  - Middle Aged
MH  - Polydeoxyribonucleotides/administration & dosage/*therapeutic use
MH  - Tennis Elbow/*drug therapy
MH  - Treatment Outcome
EDAT- 2018/05/17 06:00
MHDA- 2018/05/25 06:00
CRDT- 2018/05/17 06:00
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/25 06:00 [medline]
AID - 10.1097/MD.0000000000010809 [doi]
AID - 00005792-201805180-00059 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(20):e10809. doi: 10.1097/MD.0000000000010809.