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Clinical and immunohistochemical study of melanotic neuroectodermal tumor of infancy in the maxilla.

Abstract Melanotic neuroectodermal tumor of infancy is a rare and fast-growing neoplasm. In this study, we describe the case of a 6-month-old female patient, who presented swelling in the anterior maxilla. Tomographic reconstruction showed an unilocular hypodense and expansive area associated with the upper right central primary incisor. The presumptive diagnoses were dentigerous cyst, adenomatoid odontogenic tumor, melanotic neuroectodermal tumor of infancy and rhabdomyosarcoma, and an incisional biopsy was performed. Microscopically, the lesion revealed a biphasic cell population, consisting of small, ovoid, neuroblastic-like cells and epithelioid cells containing melanin. Immunohistochemically, the melanocyte-like component was strongly and diffusely positive for HMB-45 and Melan-A, but weakly positive for S100. Based on these findings, definitive diagnosis of melanotic neuroectodermal tumor of infancy was established. Then, enucleation of the lesion was performed by careful curettage. After 2 year follow-up, no clinical or radiographical evidence of recurrence was verified. The present case highlights the importance of early diagnosis and therapeutic intervention at the appropriate time to achieve a favorable outcome for the patient.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title einstein (sao paulo, brazil)
Publication Year Start




PMID- 29768520
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 2317-6385 (Electronic)
IS  - 1679-4508 (Linking)
VI  - 16
IP  - 2
DP  - 2018 May 14
TI  - Clinical and immunohistochemical study of melanotic neuroectodermal tumor of
      infancy in the maxilla.
PG  - eRC4025
LID - S1679-45082018000200500 [pii]
LID - 10.1590/S1679-45082018RC4025 [doi]
AB  - Melanotic neuroectodermal tumor of infancy is a rare and fast-growing neoplasm.
      In this study, we describe the case of a 6-month-old female patient, who
      presented swelling in the anterior maxilla. Tomographic reconstruction showed an 
      unilocular hypodense and expansive area associated with the upper right central
      primary incisor. The presumptive diagnoses were dentigerous cyst, adenomatoid
      odontogenic tumor, melanotic neuroectodermal tumor of infancy and
      rhabdomyosarcoma, and an incisional biopsy was performed. Microscopically, the
      lesion revealed a biphasic cell population, consisting of small, ovoid,
      neuroblastic-like cells and epithelioid cells containing melanin.
      Immunohistochemically, the melanocyte-like component was strongly and diffusely
      positive for HMB-45 and Melan-A, but weakly positive for S100. Based on these
      findings, definitive diagnosis of melanotic neuroectodermal tumor of infancy was 
      established. Then, enucleation of the lesion was performed by careful curettage. 
      After 2 year follow-up, no clinical or radiographical evidence of recurrence was 
      verified. The present case highlights the importance of early diagnosis and
      therapeutic intervention at the appropriate time to achieve a favorable outcome
      for the patient.
FAU - Santos, Hellen Bandeira de Pontes
AU  - Santos HBP
AD  - Universidade Estadual da Paraiba, Campina Grande, PB, Brazil.
FAU - Luna, Anibal Henrique Barbosa de
AU  - Luna AHB
AD  - Universidade Federal da Paraiba, Joao Pessoa, PB, Brazil.
FAU - Goes, Pedro Everton Marques
AU  - Goes PEM
AD  - Universidade Federal da Paraiba, Joao Pessoa, PB, Brazil.
FAU - Sverzut, Alexander Tadeu
AU  - Sverzut AT
AD  - Universidade Estadual de Campinas, Piracicaba, SP, Brazil.
FAU - Nonaka, Cassiano Francisco Weege
AU  - Nonaka CFW
AD  - Universidade Estadual da Paraiba, Campina Grande, PB, Brazil.
FAU - Alves, Pollianna Muniz
AU  - Alves PM
AD  - Universidade Estadual da Paraiba, Campina Grande, PB, Brazil.
LA  - eng
LA  - por
PT  - Case Reports
DEP - 20180514
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
SB  - IM
MH  - Biopsy
MH  - Early Detection of Cancer
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Maxillary Neoplasms/diagnosis/*pathology
MH  - Neuroectodermal Tumor, Melanotic/diagnosis/*pathology
MH  - Tomography, X-Ray Computed
EDAT- 2018/05/17 06:00
MHDA- 2018/05/31 06:00
CRDT- 2018/05/17 06:00
PHST- 2017/02/14 00:00 [received]
PHST- 2017/07/31 00:00 [accepted]
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - S1679-45082018000200500 [pii]
AID - 10.1590/S1679-45082018RC4025 [doi]
PST - epublish
SO  - Einstein (Sao Paulo). 2018 May 14;16(2):eRC4025. doi:
      10.1590/S1679-45082018RC4025.