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Evaluation of the effect of dose-dependent platelet-rich fibrin membrane on treatment of gingival recession: a randomized, controlled clinical trial.

Abstract Miller's class I gingival recessions (GR) have been treated using coronally advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or connective tissue graft (CTG). The aim of this study was to evaluate the effect of different multiple layers of PRF membranes for the treatment of GR compared with the CTG procedure. Sixty-three Miller class I GR were treated in this study. Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test group-2), and CTG+CAF in the control group. The plaque index (PI), gingival index (GI), probing depth (PD), keratinized tissue thickness (KTT), clinical attachment level (CAL), recession depth (RD), recession width (RW), and keratinized tissue height (KTH) measurements were performed at baseline and 1, 3, and 6 months after surgery. The post-operative discomfort of patients, assessed with the visual analog scale (VAS) and healing index (HI), was recorded after surgery. PI, GI, and PD scores were similar for all patients at all times. RD and RW scores were similar for each patient at 1 month, but these values were significantly increased in the subsequent periods in test group-1. The increase in KTT was significantly higher in the control group compared with the test groups. Similar root coverage scores were obtained in the test group-2 and control groups, and these scores were significantly higher compared with test group-1. The PRF membrane+CAF technique may be an alternative to the CTG+CAF technique for postoperative patient comfort. However, PRF membranes should use as many layers as possible.
PMID
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Authors

Mayor MeshTerms

Surgical Flaps

Keywords
Journal Title journal of applied oral science : revista fob
Publication Year Start




PMID- 29768524
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1678-7765 (Electronic)
IS  - 1678-7757 (Linking)
VI  - 26
DP  - 2018 May 14
TI  - Evaluation of the effect of dose-dependent platelet-rich fibrin membrane on
      treatment of gingival recession: a randomized, controlled clinical trial.
PG  - e20170278
LID - S1678-77572018000100453 [pii]
LID - 10.1590/1678-7757-2017-0278 [doi]
AB  - Miller's class I gingival recessions (GR) have been treated using coronally
      advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or
      connective tissue graft (CTG). The aim of this study was to evaluate the effect
      of different multiple layers of PRF membranes for the treatment of GR compared
      with the CTG procedure. Sixty-three Miller class I GR were treated in this study.
      Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF
      in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test
      group-2), and CTG+CAF in the control group. The plaque index (PI), gingival index
      (GI), probing depth (PD), keratinized tissue thickness (KTT), clinical attachment
      level (CAL), recession depth (RD), recession width (RW), and keratinized tissue
      height (KTH) measurements were performed at baseline and 1, 3, and 6 months after
      surgery. The post-operative discomfort of patients, assessed with the visual
      analog scale (VAS) and healing index (HI), was recorded after surgery. PI, GI,
      and PD scores were similar for all patients at all times. RD and RW scores were
      similar for each patient at 1 month, but these values were significantly
      increased in the subsequent periods in test group-1. The increase in KTT was
      significantly higher in the control group compared with the test groups. Similar 
      root coverage scores were obtained in the test group-2 and control groups, and
      these scores were significantly higher compared with test group-1. The PRF
      membrane+CAF technique may be an alternative to the CTG+CAF technique for
      postoperative patient comfort. However, PRF membranes should use as many layers
      as possible.
FAU - Culhaoglu, Rana
AU  - Culhaoglu R
AD  - Oral and Dental Health Center, Kirikkale, Turkey.
FAU - Taner, Levent
AU  - Taner L
AD  - Gazi University, Faculty of Dentistry, Department of Periodontology, Ankara,
      Turkey.
FAU - Guler, Berceste
AU  - Guler B
AD  - Dumlupinar University, Faculty of Dentistry, Department of Periodontology,
      Kutahya, Turkey.
LA  - eng
SI  - ClinicalTrials.gov/NCT02882464
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180514
PL  - Brazil
TA  - J Appl Oral Sci
JT  - Journal of applied oral science : revista FOB
JID - 101189774
SB  - D
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Connective Tissue/transplantation
MH  - Dental Plaque Index
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gingival Recession/*drug therapy/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Periodontal Index
MH  - Platelet-Rich Fibrin/*chemistry
MH  - Postoperative Period
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
MH  - *Surgical Flaps
MH  - Time Factors
MH  - Treatment Outcome
MH  - Visual Analog Scale
MH  - Young Adult
PMC - PMC5958936
EDAT- 2018/05/17 06:00
MHDA- 2018/05/31 06:00
CRDT- 2018/05/17 06:00
PHST- 2017/06/16 00:00 [received]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - S1678-77572018000100453 [pii]
AID - 10.1590/1678-7757-2017-0278 [doi]
PST - epublish
SO  - J Appl Oral Sci. 2018 May 14;26:e20170278. doi: 10.1590/1678-7757-2017-0278.