PubTransformer

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PMID- 29768537
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 33
IP  - 4
DP  - 2018 Apr
TI  - The protection effect and mechanism of hyperbaric oxygen therapy in rat brain
      with traumatic injury.
PG  - 341-353
LID - S0102-86502018000400341 [pii]
LID - 10.1590/s0102-865020180040000006 [doi]
AB  - PURPOSE: To investigate the effect of hyperbaric oxygen therapy (HBOT) on
      traumatic brain injury (TBI) outcome. METHODS: The modified Marmarou's weight
      drop device was used to generate non-lethal moderate TBI rat model, and further
      developed in vitro astrocytes culturing system. Then, we analyzed the expression 
      changes of interested genes and protein by quantitative PCR and western blot.
      RESULTS: Multiple HBO treatments significantly reduced the expression of
      apoptosis promoting genes, such as c-fos, c-jun, Bax and weakened the activation 
      of Caspase-3 in model rats. On the contrary, HBOT alleviated the decrease of
      anti-apoptosis gene Bcl-2 and promoted the expression of neurotrophic factors
      (NTFs), such as NGF, BDNF, GDNF and NT-3 in vivo. As a consequent, the
      neuropathogenesis was remarkably relied with HBOT. Astrocytes from TBI brain or
      those cultured with 21% O2 density expressed higher NTFs than that of
      corresponding controls, from sham brain and cultured with 7% O2, respectively.
      The NTFs expression was the highest in astrocytes form TBI brain and cultured
      with 21% O2, suggesting a synergistic effect existed between TBI and the
      following HBO treatment in astrocytes. CONCLUSION: Our findings provided evidence
      for the clinical usage of HBO treating brain damages.
FAU - Xing, Pengcheng
AU  - Xing P
AD  - MD, Department of Emergency and Intensive Care Unit, Shanghai Sixth People's
      Hospital East, China. Acquisition, analysis and interpretation of data;
      manuscript preparation.
FAU - Ma, Ke
AU  - Ma K
AD  - MD, Department of Emergency and Intensive Care Unit, Shanghai Sixth People's
      Hospital East, China. Conception and design of the study, manuscript preparation,
      final approval.
FAU - Li, Lijuan
AU  - Li L
AD  - MD, Physician, Department of Geriatrics, Shanghai Sixth People's Hospital East,
      China. Acquisition of data, technical procedures.
FAU - Wang, Donglian
AU  - Wang D
AD  - MD, Physician, Department of Emergency and Intensive Care Unit, Shanghai Sixth
      People's Hospital East, China. Technical procedures.
FAU - Hu, Guoyong
AU  - Hu G
AD  - MD, Physician, Department of Emergency and Intensive Care Unit, Shanghai Sixth
      People's Hospital East, China. Technical procedures.
FAU - Long, Wei
AU  - Long W
AD  - MD, Physician, Department of Geriatrics, Shanghai Sixth People's Hospital East,
      China. Technical procedures.
LA  - eng
PT  - Evaluation Studies
PT  - Journal Article
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Nerve Growth Factors)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Astrocytes/physiology
MH  - Blotting, Western
MH  - Brain Injuries, Traumatic/pathology/*therapy
MH  - Caspase 3/physiology
MH  - Disease Models, Animal
MH  - Hyperbaric Oxygenation/*methods
MH  - Male
MH  - Nerve Growth Factors/analysis
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Reproducibility of Results
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2018/05/17 06:00
MHDA- 2018/05/31 06:00
CRDT- 2018/05/17 06:00
PHST- 2017/12/27 00:00 [received]
PHST- 2018/03/23 00:00 [accepted]
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - S0102-86502018000400341 [pii]
AID - 10.1590/s0102-865020180040000006 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2018 Apr;33(4):341-353. doi: 10.1590/s0102-865020180040000006.