PubTransformer

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PMID- 29768539
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 33
IP  - 4
DP  - 2018 Apr
TI  - Evaluation of prophylactic and therapeutic effects of sildenafil on acute
      radiation proctitis in rats.
PG  - 362-374
LID - S0102-86502018000400362 [pii]
LID - 10.1590/s0102-865020180040000008 [doi]
AB  - PURPOSE: To investigate the prophylactic and therapeutical effects of sildenafil 
      in a model of acute radiation proctitis (ARP). METHODS: All experimental
      procedures of this study was examined by histopathological, immunohistochemical
      and transmission electron microscopic analysis. RESULTS: Our histopathological
      evaluations indicated significant increases in lesion severity, cryptic apsis,
      cryptitis, cryptic distortion, reactive atypia and infiltration depth of the
      control (proctitis) group. While the prophylaxis group and the treatment group
      had significantly lower scores. High-dose group showed similar results as
      prophylaxis group. Histopathological findings of the prophylaxis group was more
      significant than the treatment group. Immunoreactivities of IL-1beta, FGF-2, TNF-
      alpha and HIF-1alpha increased in the control group especially in the epithelial 
      and cryptic regions. On the contrary, sildenafil application caused significant
      decreases of inflammatory markers in all treatment groups, specifically better
      results in the prophylaxis group. CONCLUSION: The sildenafil has
      anti-inflammatory effects on ARP, as well as protective effects against ARP and
      the protective effect of sildenafil surpasses its therapeutic effect
      histopathologically.
FAU - Yavuz, Erkan
AU  - Yavuz E
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Ercan, Gulcin
AU  - Ercan G
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Karagulle, Onur Olgac
AU  - Karagulle OO
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Bayrak, Busra Yaprak
AU  - Bayrak BY
AD  - MD, Department of Pathology, University of Health Science Derince Training and
      Research Hospital, Kocaeli, Turkey. Histopathological examinations, acquisition
      of data, statistical analysis.
FAU - Biricik, Aytac
AU  - Biricik A
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Ercetin, Candas
AU  - Ercetin C
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Gokcek, Berk
AU  - Gokcek B
AD  - MD, Department of General Surgery, University of Health Science Okmeydani
      Training and Research Hospital, Istanbul, Turkey. Manuscript preparation and
      writing, critical revision.
FAU - Yigitbas, Hakan
AU  - Yigitbas H
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Kusaslan, Ramazan
AU  - Kusaslan R
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Celik, Atilla
AU  - Celik A
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
FAU - Gulcicek, Osman Bilgin
AU  - Gulcicek OB
AD  - MD, Department of General Surgery, University of Health Science Bagcilar Training
      and Research Hospital, Istanbul, Turkey. Scientific, intellectual, conception and
      design of the study; analysis and interpretation of data; technical procedures;
      critical revision; final approval.
LA  - eng
PT  - Evaluation Studies
PT  - Journal Article
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Protective Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - BW9B0ZE037 (Sildenafil Citrate)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Fibroblast Growth Factor 2/analysis
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/analysis
MH  - Immunohistochemistry
MH  - Interleukin-1beta/analysis
MH  - Microscopy, Electron, Transmission
MH  - Post-Exposure Prophylaxis/*methods
MH  - Proctitis/*drug therapy/*etiology/pathology
MH  - Protective Agents/pharmacology
MH  - Radiation Injuries, Experimental/*drug therapy/pathology
MH  - Random Allocation
MH  - Rectum/pathology
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Sildenafil Citrate/*pharmacology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Vascular Endothelial Growth Factor A/analysis
EDAT- 2018/05/17 06:00
MHDA- 2018/05/31 06:00
CRDT- 2018/05/17 06:00
PHST- 2017/12/16 00:00 [received]
PHST- 2018/05/20 00:00 [accepted]
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - S0102-86502018000400362 [pii]
AID - 10.1590/s0102-865020180040000008 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2018 Apr;33(4):362-374. doi: 10.1590/s0102-865020180040000008.